Bioactive Materials,
Год журнала:
2024,
Номер
42, С. 112 - 123
Опубликована: Авг. 29, 2024
Skin-nerve
interaction
plays
an
important
role
in
promoting
wound
healing.
However,
diabetic
ulcers
(DUs),
the
periphery
neuropathy
and
excessive
levels
of
reactive
oxygen
species
(ROS)
block
skin-nerve
further
impede
DUs
Herein,
we
developed
a
nanoscale
metal-organic
framework
loaded
with
nerve
growth
factor
(NGF/Ce-UiO-66,
denoted
NGF/CU)
for
treatment
DUs.
The
Ce-UiO-66
(CU)
was
applied
as
antioxidant
to
scavenge
ROS
reduce
inflammatory
response
while
NGF
aided
recovery
cutaneous
nerves
promote
Both
Abstract
Cascade
reactions
are
described
as
efficient
and
versatile
tools,
organized
catalytic
cascades
can
significantly
improve
the
efficiency
of
chemical
interworking
between
nanozymes.
They
have
attracted
great
interest
in
many
fields
such
chromogenic
detection,
biosensing,
tumor
diagnosis,
therapy.
However,
how
to
selectively
kill
cells
by
enzymatic
without
harming
normal
cells,
well
exploring
two
or
more
enzyme‐engineered
nanoreactors
for
cascading
reactions,
remain
challenges
field
targeted
specific
cancer
diagnostics
The
latest
research
advances
nanozyme‐catalyzed
cascade
processes
diagnosis
therapy
this
article.
Here,
various
sensing
strategies
summarized,
tumor‐specific
diagnostics.
Targeting
mechanisms
treatment
using
nanozymes
classified
analyzed,
“elements”
“dimensions”
nanozymes,
types,
designs
structure,
assembly
modes
highly
active
a
variety
new
targeting
based
on
reaction
Finally,
integrated
application
systems
tumor‐targeted
diagnostic
is
which
will
lay
foundation
design
rational,
efficient,
therapeutic
modalities
future.
Asian Journal of Pharmaceutical Sciences,
Год журнала:
2025,
Номер
20(1), С. 101017 - 101017
Опубликована: Янв. 10, 2025
Biological
nanotechnologies
based
on
functional
nanoplatforms
have
synergistically
catalyzed
the
emergence
of
cancer
therapies.
As
a
subtype
metal-organic
frameworks
(MOFs),
zeolitic
imidazolate
(ZIFs)
exploded
in
popularity
field
biomaterials
as
excellent
protective
materials
with
advantages
conformational
flexibility,
thermal
and
chemical
stability,
controllability.
With
these
superior
properties,
applications
ZIF-based
combination
various
therapies
for
treatment
grown
rapidly
recent
years,
showing
remarkable
achievements
great
potential.
This
review
elucidates
advancements
use
ZIFs
drug
delivery
agents
therapy.
The
structures,
synthesis
methods,
modifiers
used
oncotherapy
are
presented.
Recent
advances
application
nanoparticles
single
or
tumor
treatments
reviewed.
Furthermore,
future
prospects,
potential
limitations,
challenges
nanomaterials
discussed.
We
except
to
fully
explore
present
clear
outline
their
an
effective
help
them
achieve
early
clinical
application.
Porphyrins,
known
for
their
exceptional
photoelectrochemical
properties
and
high
luminescence,
are
promising
candidates
electrochemiluminescence
(ECL)
applications.
However,
tendency
to
aggregate
in
aqueous
solutions
due
π–π
stacking
leads
luminescence
quenching
reduced
efficiency.
To
address
this,
we
developed
a
"coordination
disaggregation-induced
enhancement"
strategy,
utilizing
metal–organic
frameworks
(MOFs)
as
stable
platforms
immobilizing
porphyrin.
These
porphyrin-based
MOFs
not
only
increase
the
loading
of
luminescent
groups
suppress
aggregation-caused
(ACQ)
effect
but
also
enhance
electron
transfer
via
uniform
dispersion
pyrrole
N
porphyrin
ligand,
thereby
improving
ECL
intensity.
Additionally,
they
exhibit
favorable
biocompatibility
low
toxicity,
making
them
suitable
biomedical
By
combining
donors
with
PDA@MnO2
composites
quenchers,
constructed
quenching-type
immunosensor
detecting
programmed
death
ligand
1
(PD-L1).
This
sensor
achieves
detection
range
10
fg/mL
100
ng/mL,
limit
2.48
fg/mL,
which
demonstrates
great
potential
highly
sensitive
biomarker
applications
early
cancer
diagnosis
other
medical
diagnostics.
