Journal of Molecular Liquids, Год журнала: 2025, Номер unknown, С. 127344 - 127344
Опубликована: Март 1, 2025
Язык: Английский
Angewandte Chemie International Edition, Год журнала: 2023, Номер 63(11)
Опубликована: Дек. 12, 2023
Abstract Organic fluorophores are indispensable tools in cells, tissue and vivo imaging, have enabled much progress the wide range of biological biomedical fields. However, many available dyes suffer from insufficient performances, such as short absorption emission wavelength, low brightness, poor stability, small Stokes shift, unsuitable permeability, restricting their application advanced imaging technology complex imaging. Over past two decades, efforts been made to improve these performances fluorophores. Starting with luminescence principle fluorophores, this review clarifies mechanisms performance for traditional a certain extent, systematically summarizes modified approaches optimizing properties, highlights typical applications improved sensing, indicates existing problems challenges area. This not only proves significance improving but also provide theoretical guidance development high‐performance
Язык: Английский
Процитировано
51
Coordination Chemistry Reviews, Год журнала: 2024, Номер 504, С. 215670 - 215670
Опубликована: Янв. 13, 2024
Язык: Английский
Процитировано
15
Nano Energy, Год журнала: 2024, Номер 125, С. 109539 - 109539
Опубликована: Март 26, 2024
Язык: Английский
Процитировано
10
ACS Applied Bio Materials, Год журнала: 2024, Номер unknown
Опубликована: Апрель 1, 2024
Recent advances have been made in second near-infrared (NIR-II) fluorescence bioimaging and many related applications because of its advantages deep penetration, high resolution, minimal invasiveness, good dynamic visualization. To achieve high-performance NIR-II bioimaging, various materials probes with bright emission extensively explored the past few years. Among these emissive materials, conjugated polymers small molecules attracted wide interest due to their native biosafety tunable optical performance. This review summarizes brightness strategies available for highlights recent developments bioimaging. A concise, detailed overview molecular design regulatory approaches is provided terms brightness, long wavelengths, superior imaging Then, typical cases which are used as introduced by providing step-by-step examples. Finally, current problems challenges associated accessing briefly discussed, significance future prospects proposed offer helpful guidance development materials.
Язык: Английский
Процитировано
10
Nature Communications, Год журнала: 2025, Номер 16(1)
Опубликована: Янв. 2, 2025
Chemiluminescence (CL) is a self-illuminating phenomenon fueled by chemical energy instead of extra excited light, which features superiority in sensitivity, signal-to-background ratios, and imaging depth. Strategies to synthesize CL emission unimolecular skeleton the second near-infrared window (NIR-II) probe with direct duplex NIR-II [CL/fluorescence (FL)] are lacking. Here, we employ modular synthesis routes construct series directly activated probes maximum wavelength up 1060 nm, use them for real-time continuous detection superoxide anion generated acetaminophen induced liver injury female mice model under both FL channels. Thus, this study establishes activatable skeleton, validating scalability CL/FL platform bioactive molecule disease diagnosis. chemiluminescence authors NIRII
Язык: Английский
Процитировано
2
Angewandte Chemie, Год журнала: 2023, Номер 136(11)
Опубликована: Дек. 12, 2023
Abstract Organic fluorophores are indispensable tools in cells, tissue and vivo imaging, have enabled much progress the wide range of biological biomedical fields. However, many available dyes suffer from insufficient performances, such as short absorption emission wavelength, low brightness, poor stability, small Stokes shift, unsuitable permeability, restricting their application advanced imaging technology complex imaging. Over past two decades, efforts been made to improve these performances fluorophores. Starting with luminescence principle fluorophores, this review clarifies mechanisms performance for traditional a certain extent, systematically summarizes modified approaches optimizing properties, highlights typical applications improved sensing, indicates existing problems challenges area. This not only proves significance improving but also provide theoretical guidance development high‐performance
Язык: Английский
Процитировано
23
Materials Today Bio, Год журнала: 2024, Номер 26, С. 101028 - 101028
Опубликована: Март 24, 2024
The expansion applications of semiconducting polymer dots (Pdots) among optical nanomaterial field have long posed a challenge for researchers, promoting their intelligent application in multifunctional nano-imaging systems and integrated nanomedicine carriers diagnosis treatment. Despite notable progress, several inadequacies still persist the Pdots, including development simplified near-infrared (NIR) nanoprobes, elucidation inherent biological behavior, integration information processing nanotechnology into biomedical applications. This review aims to comprehensively elucidate current status Pdots as classical nanophotonic material by discussing its advantages limitations terms biocompatibility, adaptability microenvironments vivo, etc. Multifunctional surface chemistry play crucial roles realizing Pdots. Information visualization based on physicochemical properties is pivotal achieving detection, sensing, labeling probes. Therefore, we refined underlying mechanisms constructed multiple comprehensive original mechanism summaries establish benchmark. Additionally, explored cross-linking interactions between nanomedicine, potential yet complete metabolic pathways, future research directions, innovative solutions integrating treatment strategies. presents possible expectations valuable insights advancing specifically from chemical, medical, photophysical practitioners' standpoints.
Язык: Английский
Процитировано
8
Chemical Reviews, Год журнала: 2024, Номер 124(16), С. 9225 - 9375
Опубликована: Авг. 13, 2024
Reactive oxygen and nitrogen species are small reactive molecules derived from elements in the air─oxygen nitrogen. They produced biological systems to mediate fundamental aspects of cellular signaling but must be very tightly balanced prevent indiscriminate damage molecules. Small molecule probes can transmute specific nature each into an observable luminescent signal (or even acoustic wave) offer sensitive selective imaging living cells whole animals. This review focuses specifically on for superoxide, hydrogen peroxide, hypochlorite, nitric oxide, peroxynitrite that provide a or photoacoustic signal. Important background information general photophysical phenomena, common probe designs, mechanisms, modalities will provided, then, analyte thoroughly evaluated. A discussion successes field presented, followed by recommendations improvement future outlook emerging trends. Our objectives informative, useful, thorough guide as well important context compare ecosystem chemistries molecular scaffolds has manifested within field.
Язык: Английский
Процитировано
8
Journal of Materials Chemistry B, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Near-infrared fluorescence imaging is key in biological exploration. Short emission wavelengths of xanthene dyes limit their use. Structural modifications shift emissions to the NIR-I/II range, enhancing biomedical applications.
Язык: Английский
Процитировано
1
Chemical Communications, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Molecular sensors respond to the presence of biological analytes by producing signals that are either directly perceivable human sensory systems or converted into electric signals, which require electronic devices for communicating humans. Here, we review outputs molecular detectable senses. According literature, with visual dominate. Undeservedly unnoticed, release gases might be particularly useful since gas output can detected several senses in a quantifiable format. Relatively new tactile accessed visually impaired people. their bypassing may contribute development point-of-care testing technologies, as well providing direct communication nanorobots
Язык: Английский
Процитировано
1