RSC Advances,
Journal Year:
2025,
Volume and Issue:
15(15), P. 11893 - 11901
Published: Jan. 1, 2025
A
novel
nanocatalyst
based
on
Cu/Au-doped
polypyrrole
has
been
synthesized
for
NIR
II
laser-promoted
nanocatalytic
tumor
therapy
through
several
enhanced
catalytic
mechanisms,
including
elevated
temperature
and
electron
migration.
Chemical Reviews,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 27, 2025
Nanozymes
have
shown
significant
potential
in
cancer
catalytic
therapy
by
strategically
catalyzing
tumor-associated
substances
and
metabolites
into
toxic
reactive
oxygen
species
(ROS)
situ,
thereby
inducing
oxidative
stress
promoting
cell
death.
However,
within
the
complex
tumor
microenvironment
(TME),
rational
design
of
nanozymes
factors
like
activity,
reaction
substrates,
TME
itself
significantly
influence
efficiency
ROS
generation.
To
address
these
limitations,
recent
research
has
focused
on
exploring
that
affect
activity
developing
nanozyme-based
cascade
systems,
which
can
trigger
two
or
more
processes
tumors,
producing
therapeutic
achieving
efficient
stable
with
minimal
side
effects.
This
area
remarkable
progress.
Perspective
provides
a
comprehensive
overview
nanozymes,
covering
their
classification
fundamentals.
The
regulation
nanozyme
strategies
are
discussed
detail.
Furthermore,
representative
paradigms
for
successful
construction
systems
treatment
summarized
focus
revealing
underlying
mechanisms.
Finally,
we
current
challenges
future
prospects
development
biomedical
applications.
Journal of the American Chemical Society,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 17, 2025
Gasdermin
(GSDM)-mediated
pyroptosis
involves
the
induction
of
mitochondrial
damage
and
subsequent
release
DNA
(mtDNA),
which
is
anticipated
to
activate
cGAS-STING
pathway,
thereby
augmenting
antitumor
immune
response.
However,
challenges
lie
in
effectively
triggering
cancer
cells
subsequently
enhancing
activation
with
specificity.
Herein,
we
developed
intelligent
self-cascaded
pyroptosis-STING
initiators
cobalt
fluoride
(CoF2)
nanocatalysts
for
catalytic
metalloimmunotherapy.
CoF2
a
semiconductor
structure
enzyme-like
activity
generated
substantial
amount
reactive
oxygen
species
(ROS)
under
stimulation
by
endogenous
H2O2
exogenous
ultrasound.
Importantly,
discovered
that
Co-based
nanomaterials
themselves
induce
cells.
Therefore,
initially
acted
as
inducers,
caspase-1/GSDMD-dependent
via
Co2+
ROS,
leading
mtDNA
release.
Subsequently,
were
further
utilized
STING
agonists
specifically
capable
detecting
pathway.
These
cascade
events
triggered
robust
response,
modulating
immunosuppressive
tumor
microenvironment
into
an
immune-supportive
state,
providing
favorable
support
therapy.
This
innovative
strategy
not
only
significantly
impeded
growth
primary
but
also
elicited
response
augment
efficacy
checkpoint
inhibitors
preventing
distant
progression.
Overall,
this
study
proposed
self-cascade
activating
amplifying
pathway
specificity
mediated
pyroptosis,
representing
valuable
avenue
future
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(34), P. 23672 - 23683
Published: Aug. 13, 2024
Engineering
Z-scheme
heterojunctions
represents
a
promising
strategy
for
optimizing
the
separation
and
migration
of
charge
carriers
in
semiconductor
sonosensitizers
enhanced
reactive
oxygen
species
(ROS)
generation.
Nevertheless,
establishing
continuous
directional
pathway
ultrasonic-induced
flow
remains
significant
challenge.
In
this
study,
we
present
ternary
Bi
ACS Nano,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 20, 2025
Cytokine
therapeutics
in
cancer
immunotherapy
are
greatly
limited
by
their
short
half-time,
serious
toxicity,
and
frequent
administration,
which
can
possibly
be
addressed
ribonucleic
acid
(RNA)
technology
through
the
expression
of
targeting
cytokines
situ.
However,
intracellular
translation
RNA
remains
restricted
due
to
generation
excessive
reactive
oxygen
species
(ROS)
overconsumption
adenosine
triphosphate
(ATP)
within
transfected
cells.
Herein,
hybrid
lipid
nanoparticles
(Mn-LNPs)
developed
incorporating
small-sized
trimanganese
tetraoxide
conventional
nanoparticles,
showing
ability
generate
oxygen,
eliminate
ROS,
boost
ATP,
thus
enhancing
efficiency.
This
platform
is
employed
encapsulate
interleukin
12
(IL-12)-encoding
circular
(Mn-LNPs@RNAIL-12)
for
tumor
immunotherapy,
exhibiting
unparalleled
advantages
proliferation
cytotoxic
T
cells
stimulation
antitumor
immunity.
Moreover,
efficacy
Mn-LNPs@RNAIL-12
further
strengthened
synergizing
with
immune
checkpoint
blockade
therapy
achieve
durable
potent
performances.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 28, 2024
Abstract
Doxorubicin
(DOX),
a
potent
antineoplastic
agent,
is
commonly
associated
with
cardiotoxicity,
necessitating
the
development
of
strategies
to
reduce
its
adverse
effects
on
cardiac
function.
Previous
research
has
demonstrated
strong
correlation
between
DOX‐induced
cardiotoxicity
and
activation
oxidative
stress
pathways.
This
work
introduces
novel
antioxidant
therapeutic
approach,
utilizing
libraries
tannic
acid
N‐acetyl‐L‐cysteine‐protected
bimetallic
cluster
nanozymes.
Through
extensive
screening
for
antioxidative
enzyme‐like
activity,
an
optimal
nanozyme
(AuRu)
identified
that
possess
remarkable
characteristics,
mimicking
catalase‐like
enzymes.
Theoretical
calculations
reveal
surface
interactions
prepared
nanozymes
simulate
hydrogen
peroxide
decomposition
process,
showing
these
readily
undergo
OH⁻
adsorption
O₂
desorption.
To
enhance
targeting,
atrial
natriuretic
peptide
conjugated
AuRu
nanozyme.
These
cardiac‐targeted
nanozymes,
their
anchoring
capability,
effectively
cardiomyocyte
ferroptosis
PANoptosis
without
compromising
tumor
treatment
efficacy.
Thus,
approach
demonstrates
significant
reductions
in
chemotherapy‐induced
cell
death
improvements
function,
accompanied
by
exceptional
vivo
biocompatibility
stability.
study
presents
promising
avenue
preventing
offering
potential
clinical
benefits
cancer
patients.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
11(25)
Published: April 23, 2024
The
generally
undesirable
bandgap
and
electron-hole
complexation
of
inorganic
sonosensitizers
limit
the
efficiency
reactive
oxygen
species
(ROS)
generation,
affecting
effectiveness
sonodynamic
therapy
(SDT).
Comparatively,
novel
polyvinylpyrrolidone-modified
copper
bismuthate
(PCBO)
are
manufactured
for
a
"three-step"
SDT
promotion.
In
brief,
first,
strong
hybridization
between
Bi
6s
O
2p
orbitals
in
PCBO
narrows
(1.83
eV),
facilitating
rapid
transfer
charge
carriers.
Additionally,
nonequivalent
[CuO
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(41)
Published: Aug. 16, 2024
Abstract
Bioorthogonal
chemistry
has
provided
an
elaborate
arsenal
to
manipulate
native
biological
processes
in
living
systems.
As
the
great
advancement
of
nanotechnology
recent
years,
bioorthogonal
nanozymes
are
innovated
tackle
challenges
that
emerged
practical
biomedical
applications.
uniquely
positioned
owing
their
advantages
high
customizability
and
tunability,
as
well
good
adaptability
systems,
which
bring
exciting
opportunities
for
More
intriguingly,
offers
opportunity
innovating
catalytic
materials.
In
this
comprehensive
review,
significant
progresses
discussed
with
both
spatiotemporal
controllability
performance
highlight
design
principles
rapid
The
remaining
future
perspectives
then
outlined
along
thriving
field.
It
is
expected
review
will
inspire
promote
novel
nanozymes,
facilitate
clinical
translation.