Cu/Au-doped nanopolymers with multiple catalytic activities for NIR II laser-promoted nanocatalytic tumor therapy DOI Creative Commons
Xixi Wu, Xiang Feng, Peng Yu

et al.

RSC Advances, Journal Year: 2025, Volume and Issue: 15(15), P. 11893 - 11901

Published: Jan. 1, 2025

A novel nanocatalyst based on Cu/Au-doped polypyrrole has been synthesized for NIR II laser-promoted nanocatalytic tumor therapy through several enhanced catalytic mechanisms, including elevated temperature and electron migration.

Language: Английский

Osteosarcoma-Targeting PtIV Prodrug Amphiphile for Enhanced Chemo-Immunotherapy via Ca2+ trapping DOI
Jianqin Yan, Dengshuai Wei,

Zijian Zhao

et al.

Acta Biomaterialia, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Language: Английский

Citations

22

Rational Design of Nanozymes for Engineered Cascade Catalytic Cancer Therapy DOI

Xiuna Jia,

Erkang Wang, Jin Wang

et al.

Chemical Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 27, 2025

Nanozymes have shown significant potential in cancer catalytic therapy by strategically catalyzing tumor-associated substances and metabolites into toxic reactive oxygen species (ROS) situ, thereby inducing oxidative stress promoting cell death. However, within the complex tumor microenvironment (TME), rational design of nanozymes factors like activity, reaction substrates, TME itself significantly influence efficiency ROS generation. To address these limitations, recent research has focused on exploring that affect activity developing nanozyme-based cascade systems, which can trigger two or more processes tumors, producing therapeutic achieving efficient stable with minimal side effects. This area remarkable progress. Perspective provides a comprehensive overview nanozymes, covering their classification fundamentals. The regulation nanozyme strategies are discussed detail. Furthermore, representative paradigms for successful construction systems treatment summarized focus revealing underlying mechanisms. Finally, we current challenges future prospects development biomedical applications.

Language: Английский

Citations

5

Self-Cascaded Pyroptosis-STING Initiators for Catalytic Metalloimmunotherapy DOI
Qiao Yu,

Shumin Sun,

Nailin Yang

et al.

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 17, 2025

Gasdermin (GSDM)-mediated pyroptosis involves the induction of mitochondrial damage and subsequent release DNA (mtDNA), which is anticipated to activate cGAS-STING pathway, thereby augmenting antitumor immune response. However, challenges lie in effectively triggering cancer cells subsequently enhancing activation with specificity. Herein, we developed intelligent self-cascaded pyroptosis-STING initiators cobalt fluoride (CoF2) nanocatalysts for catalytic metalloimmunotherapy. CoF2 a semiconductor structure enzyme-like activity generated substantial amount reactive oxygen species (ROS) under stimulation by endogenous H2O2 exogenous ultrasound. Importantly, discovered that Co-based nanomaterials themselves induce cells. Therefore, initially acted as inducers, caspase-1/GSDMD-dependent via Co2+ ROS, leading mtDNA release. Subsequently, were further utilized STING agonists specifically capable detecting pathway. These cascade events triggered robust response, modulating immunosuppressive tumor microenvironment into an immune-supportive state, providing favorable support therapy. This innovative strategy not only significantly impeded growth primary but also elicited response augment efficacy checkpoint inhibitors preventing distant progression. Overall, this study proposed self-cascade activating amplifying pathway specificity mediated pyroptosis, representing valuable avenue future

Language: Английский

Citations

3

Ternary Bi2WO6/TiO2–Pt Heterojunction Sonosensitizers for Boosting Sonodynamic Therapy DOI

Shengwu Wen,

Weiyun Zhang,

Jinlong Yang

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(34), P. 23672 - 23683

Published: Aug. 13, 2024

Engineering Z-scheme heterojunctions represents a promising strategy for optimizing the separation and migration of charge carriers in semiconductor sonosensitizers enhanced reactive oxygen species (ROS) generation. Nevertheless, establishing continuous directional pathway ultrasonic-induced flow remains significant challenge. In this study, we present ternary Bi

Language: Английский

Citations

13

Catalytic Hybrid Lipid Nanoparticles Potentiate Circle RNA-Based Cytokine Immunotherapy DOI

Yongcan Li,

John Kevin Gan,

Jiaqi Lei

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 20, 2025

Cytokine therapeutics in cancer immunotherapy are greatly limited by their short half-time, serious toxicity, and frequent administration, which can possibly be addressed ribonucleic acid (RNA) technology through the expression of targeting cytokines situ. However, intracellular translation RNA remains restricted due to generation excessive reactive oxygen species (ROS) overconsumption adenosine triphosphate (ATP) within transfected cells. Herein, hybrid lipid nanoparticles (Mn-LNPs) developed incorporating small-sized trimanganese tetraoxide conventional nanoparticles, showing ability generate oxygen, eliminate ROS, boost ATP, thus enhancing efficiency. This platform is employed encapsulate interleukin 12 (IL-12)-encoding circular (Mn-LNPs@RNAIL-12) for tumor immunotherapy, exhibiting unparalleled advantages proliferation cytotoxic T cells stimulation antitumor immunity. Moreover, efficacy Mn-LNPs@RNAIL-12 further strengthened synergizing with immune checkpoint blockade therapy achieve durable potent performances.

Language: Английский

Citations

1

Current roles of metals in arming sonodynamic cancer therapy DOI

Zhuoli Chen,

Xianbo Wu, Jinzhe Liang

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 521, P. 216169 - 216169

Published: Aug. 24, 2024

Language: Английский

Citations

9

A Cardiac‐Targeting and Anchoring Bimetallic Cluster Nanozyme Alleviates Chemotherapy‐Induced Cardiac Ferroptosis and PANoptosis DOI Creative Commons
Junyue Xing, Xiaohan Ma,

Yanan Yu

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 28, 2024

Abstract Doxorubicin (DOX), a potent antineoplastic agent, is commonly associated with cardiotoxicity, necessitating the development of strategies to reduce its adverse effects on cardiac function. Previous research has demonstrated strong correlation between DOX‐induced cardiotoxicity and activation oxidative stress pathways. This work introduces novel antioxidant therapeutic approach, utilizing libraries tannic acid N‐acetyl‐L‐cysteine‐protected bimetallic cluster nanozymes. Through extensive screening for antioxidative enzyme‐like activity, an optimal nanozyme (AuRu) identified that possess remarkable characteristics, mimicking catalase‐like enzymes. Theoretical calculations reveal surface interactions prepared nanozymes simulate hydrogen peroxide decomposition process, showing these readily undergo OH⁻ adsorption O₂ desorption. To enhance targeting, atrial natriuretic peptide conjugated AuRu nanozyme. These cardiac‐targeted nanozymes, their anchoring capability, effectively cardiomyocyte ferroptosis PANoptosis without compromising tumor treatment efficacy. Thus, approach demonstrates significant reductions in chemotherapy‐induced cell death improvements function, accompanied by exceptional vivo biocompatibility stability. study presents promising avenue preventing offering potential clinical benefits cancer patients.

Language: Английский

Citations

9

Novel Spatially Asymmetric Copper Bismuthate‐Mediated Augmentation of Energy Conversion to Realize “Three‐Step” Tumor Suppression DOI Creative Commons
Jiarui Wang,

Haoqin Zheng,

Guangyao Hu

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(25)

Published: April 23, 2024

The generally undesirable bandgap and electron-hole complexation of inorganic sonosensitizers limit the efficiency reactive oxygen species (ROS) generation, affecting effectiveness sonodynamic therapy (SDT). Comparatively, novel polyvinylpyrrolidone-modified copper bismuthate (PCBO) are manufactured for a "three-step" SDT promotion. In brief, first, strong hybridization between Bi 6s O 2p orbitals in PCBO narrows (1.83 eV), facilitating rapid transfer charge carriers. Additionally, nonequivalent [CuO

Language: Английский

Citations

7

Nanomaterials in the diagnosis and treatment of gastrointestinal tumors: New clinical choices and treatment strategies DOI Creative Commons
Liping Chen,

Qingqing Li

Materials Today Bio, Journal Year: 2025, Volume and Issue: 32, P. 101782 - 101782

Published: April 19, 2025

Language: Английский

Citations

1

Smart Bioorthogonal Nanozymes: From Rational Design to Appropriate Bioapplications DOI
Bin Zhang, Jiawei Zhu, Jinsong Ren

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(41)

Published: Aug. 16, 2024

Abstract Bioorthogonal chemistry has provided an elaborate arsenal to manipulate native biological processes in living systems. As the great advancement of nanotechnology recent years, bioorthogonal nanozymes are innovated tackle challenges that emerged practical biomedical applications. uniquely positioned owing their advantages high customizability and tunability, as well good adaptability systems, which bring exciting opportunities for More intriguingly, offers opportunity innovating catalytic materials. In this comprehensive review, significant progresses discussed with both spatiotemporal controllability performance highlight design principles rapid The remaining future perspectives then outlined along thriving field. It is expected review will inspire promote novel nanozymes, facilitate clinical translation.

Language: Английский

Citations

6