The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(5), С. 2996 - 3009
Опубликована: Фев. 15, 2024
An
efficient
and
highly
regioselective
C6-phosphorylation
protocol
for
pyrrolo[2,3-d]pyrimidine
(7-DAP)
derivatives
with
various
H-phosphine
oxides
induced
by
visible
light
at
room
temperature
is
described
the
first
time.
This
has
been
successfully
achieved
combination
of
Na2-eosin
Y
as
a
photocatalyst
LPO
an
oxidant
under
transition
metal-
additive-free
conditions.
The
broad
substrate
scope,
good
functional
group
tolerance,
excellent
regioselectivity,
air
tolerant
conditions
make
this
process
favorable
modification
scaffold
enrich
phosphorylated
7-DAP
compounds
further
biological
evaluation.
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(10), С. 7047 - 7057
Опубликована: Апрель 26, 2024
An
efficient
method
for
the
construction
of
C–P(V)
and
C–P(III)
bonds
via
iron-catalyzed
phosphorylation
alcohols
under
ligand-free
conditions
is
disclosed.
This
strategy
represents
a
straightforward
process
to
prepare
series
phosphine
oxides
compounds
in
good
excellent
yields
from
readily
available
P–H
compounds.
A
plausible
mechanism
also
proposed.
We
anticipate
that
this
mode
transforming
simple
would
apply
chemical
synthesis
widely.
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(5), С. 3259 - 3270
Опубликована: Фев. 21, 2024
The
NaOAc-assisted
aerobic
oxidation
reaction
of
pentacoordinate
hydrospirophosphoranes
and
dichalcogenyl
compounds
with
open
air
as
a
green
oxidant
has
been
developed
under
mild
conditions.
A
series
novel
spirophosphoranes
P–Se/P–S
bonds
were
synthesized
in
excellent
yields.
mechanism
was
determined
by
31P
nuclear
magnetic
resonance
tracing
experiments,
high-resolution
mass
spectrometry
X-ray
diffraction
analysis.
method
features
broad
substrate
scope,
good
functional
group
tolerance,
high
degree
atomic
utilization
is
meaningful
for
the
synthesis
bioactive
chalcogenphosphate
chalcogen
phosphorus
moieties.
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 22, 2025
An
external
reductant-free
and
acid-free
synthesis
of
phosphonothioates
from
odorless
sodium
sulfinates
induced
by
CCl4
(1.0
equiv)
under
mild
conditions
has
been
achieved.
This
transformation
provides
an
efficient
synthetic
approach
to
in
up
98%
yield
with
good
functional
group
compatibility.
In
addition,
unexpected
CCl4-induced
sulfoxides
sulfones
using
DMSO
as
the
solvent
developed.
Organic Letters,
Год журнала:
2024,
Номер
26(2), С. 565 - 570
Опубликована: Янв. 4, 2024
An
aerobic
oxidative
cleavage
of
1,3-diketones
under
visible
light
irradiation
using
an
organic
dye
as
a
photocatalyst
is
disclosed.
The
newly
developed
reaction
provides
practical
access
to
1,2-diketones
and
(Z)-1,4-enediones
in
moderate
good
yields
with
absolute
regio-
stereoselectivity.
Mechanistic
studies
the
suggest
that
tetraketone
intermediates
might
undergo
photocatalytic
energy
transfer
from
excited
form
biradical-like
(n,π*)
states
ketones.
Organic & Biomolecular Chemistry,
Год журнала:
2023,
Номер
21(32), С. 6488 - 6492
Опубликована: Янв. 1, 2023
Photocatalytic
C(sp3)-H
phosphorylation
of
xanthenes
and
9,10-dihydroacridines
with
P(O)-H
compounds
under
the
irradiation
18
W
blue
LEDs
at
room
temperature
using
fluorescein
as
photocatalyst
molecular
oxygen
(O2)
sole
oxidant
has
been
achieved.
The
newly
developed
reaction
provides
direct
access
to
9-phosphorylated
xanthene
derivatives
good
functional
group
compatibility.
