Abstract
Useful
monophosphorus
products
are
obtained
from
both
white
and
red
phosphorus
via
a
simple
strategy
involving
initial
oxidation
by
aryl
disulfides
followed
quenching
with
nucleophiles.
Direct
transformations
of
elemental
usually
very
challenging,
forcing
chemists
to
instead
rely
on
inefficient
hazardous
multi‐step
methods.
However,
here
they
achieved
using
inexpensive
easy‐to‐handle
reagents,
providing
access
diverse
P−C,
P−N
P−O
bonded
in
good
yields.
By
isolating
the
thiolate
byproducts
these
reactions,
simple,
closed
loop
can
be
that
produces
only
minimal,
benign
waste
byproducts,
contrast
other
direct
This
even
elaborated
into
true
(electro)catalytic
cycle,
which
is
extremely
rare
field
functionalization.
National Science Review,
Год журнала:
2024,
Номер
11(6)
Опубликована: Май 2, 2024
Direct
synthesis
of
organophosphorus
compounds
from
white
phosphorus
represents
a
significant
but
challenging
subject,
especially
in
the
context
ongoing
efforts
to
comprehensively
improve
phosphorus-derived
chemical
industry
driven
by
sustainability
and
safety
concerns.
China
is
world's
largest
producer
phosphorus,
creating
demand
for
green
transformation
this
crucial
feedstock.
This
review
provides
an
overview
advancements
activation
Chinese
research
teams,
focusing
on
direct
construction
P‒C/N/O/S/M
bonds
phosphorus.
Additionally,
we
offer
some
insights
into
prospective
directions
future.
paper
aims
attract
more
researchers
engage
area,
stimulating
follow-up
exploration
fostering
enduring
advances.
Organic Chemistry Frontiers,
Год журнала:
2024,
Номер
11(17), С. 4882 - 4894
Опубликована: Янв. 1, 2024
This
review
focuses
on
the
synthesis
of
C–P
bonds
using
carbon-centered
radicals
with
phosphorous
compounds
different
valence
states
(P
III
,
P
V
4
)
under
photocatalysis.
Organic Chemistry Frontiers,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
The
first
water
mediated
synthesis
of
dialkylphosphine
oxides
and
α-hydroxy
phosphine
from
P
4
without
a
chlorination
step
oxidation
process
is
presented.
Nature Communications,
Год журнала:
2025,
Номер
16(1)
Опубликована: Фев. 26, 2025
Abstract
Inorganic
phosphates
hold
significant
potential
as
ideal
natural
building
blocks,
forming
a
fundamental
basis
for
organic
and
biochemical
synthesis.
However,
their
limited
solubility,
inherent
chemical
stability,
low
reactivity
pose
substantial
challenges
to
converting
into
organophosphates
under
mild
conditions.
This
study
introduces
an
efficient
method
the
direct
conversion
of
P(V)-X
reagents,
[TBA][PO
2
X
]
(X
=
Cl,
F),
via
redox-neutral
halogenation
process.
utilizes
cyanuric
chloride
(or
fluoride)
reagent,
in
combination
with
1-formylpyrrolidine
tetrabutylammonium
(TBAC),
ambient
The
approach
enables
effective
various
P(V)
sources,
including
orthophosphates,
pyrophosphoric
acid,
Na
3
P
O
9
5
.
Furthermore,
we
demonstrate
synthetic
utility
P(V)-Cl
reagent
phosphorylation
diverse
-,
S
N
-
C-
nucleophiles.
Key
advantages
this
process
include
use
inexpensive
readily
available
chemicals,
avoidance
high-energy
redox
reactions,
generation
reactive
yet
stable
reagent.
Molecules,
Год журнала:
2025,
Номер
30(6), С. 1367 - 1367
Опубликована: Март 18, 2025
It
was
shown
for
the
first
time
that
diaryl(hetaryl)ketones
are
capable
of
directly
phosphorylating
with
red
phosphorus
in
superbase
suspension
KOH/DMSO(H2O)
at
85
°C
1.5
h
to
afford
potassium
bis(diaryl(hetaryl)methyl)phosphates
were
earlier
inaccessible
a
yield
up
45%.
The
ESR
data
demonstrate
unlike
previously
published
phosphorylation
elemental
phosphorus,
this
new
reaction
proceeds
via
single
electron
transfer
from
polyphospide
anions
diaryl(hetaryl)ketones.
This
is
example
C-O-P
bond
generation
during
strongly
basic
media,
which
usually
provides
C-P
formation.
Chemistry - A European Journal,
Год журнала:
2023,
Номер
30(7)
Опубликована: Ноя. 6, 2023
Organophosphorus
compounds
(OPCs)
are
widely
used
in
many
fields.
However,
traditional
synthetic
routes
the
industry
usually
involve
multistep
and
hazardous
procedures.
Therefore,
it's
of
great
significance
to
construct
such
an
environmentally-friendly
facile
way.
Herein,
a
photoredox
catalytic
method
has
been
developed
novel
phosphoryltriacetates.
Using
fac-Ir(ppy)
Organic Letters,
Год журнала:
2024,
Номер
26(43), С. 9316 - 9321
Опубликована: Окт. 24, 2024
A
novel
and
efficient
method
for
the
direct
selective
alkylation
of
white
phosphorus
(P4)
with
alkyl
bromides
has
been
developed,
utilizing
4DPAIPN
as
photocatalyst
Hantzsch
ester
reductant.
This
facilitates
synthesis
structurally
diverse
dialkyl
phosphine
oxides
in
good
yields,
offering
a
streamlined
alternative
to
traditional
stepwise
approach
chlorinating
P4
Cl2
subsequently
displacing
chlorine
atom.
Noteworthy
features
this
reaction
include
excellent
product
selectivity,
remarkable
functional
group
tolerance,
broad
substrate
scope.
Additionally,
is
effective
trialkyl
oxides.
Abstract
Phosphite
antioxidants
exhibit
superior
anti‐aging
and
color‐stabilizing
properties
when
incorporated
into
polymer
materials.
Their
synergistic
antioxidative
effects
are
particularly
noteworthy
used
in
combination
with
hindered
phenol
other
primary
antioxidants,
serving
as
effective
secondary
displaying
antioxidation
effects.
This
review
systematically
classifies
the
synthetic
methods
for
phosphite
three
distinct
categories
based
on
types
of
starting
materials:
synthesis
from
phosphorus
trichloride,
phosphorus‐containing
esters,
white
phosphorus.
Additionally,
it
delineates
reaction
mechanisms
associated
these
approaches
provides
an
overview
future
potential
research
directions
applications
organophosphorus
antioxidants.
Chemical Communications,
Год журнала:
2024,
Номер
60(99), С. 14691 - 14702
Опубликована: Янв. 1, 2024
This
review
highlights
the
latest
advancements
in
synthesis
of
phosphorothioates
and
their
derivatives
from
inorganic
phosphorus
sources,
focusing
on
applicability,
mechanisms,
current
limitations,
potential
future
directions.
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Июнь 20, 2024
Abstract
Modern
synthesis
methods
of
organophosphorus
heavily
rely
on
white
phosphorus
and
its
(oxy)chlorination
reagents.
Phosphates
have
the
potential
to
serve
as
perfect
natural
building
blocks,
forming
basis
for
organic
biochemical
syntheses.
However,
poor
solubility,
high
stability,
low
reactivity
make
it
challenging
transformation
phosphates
active
reagents
under
mild
conditions.
Here
we
show
an
efficient
conversion
in
which
various
phosphate
sources
are
directly
transformed
into
[TBA][PO2X2]
(X
=
Cl,
F)
phosphorylation
through
a
redox-neutral
process
by
using
cyanuric
chloride
1-formylpyrrolidine
presence
tetrabutylammonium
at
ambient
Key
features
this
involve
utilization
cost-effective
readily
available
chemicals,
circumventing
need
redox
reactions
with
high-energy
reactive
yet
stable
P(V)-reagent.
In
comparison
known
precursor,
[PO2X2]-
salts
bench-stable,
easy
handle,
affording
compounds
before
substrates.
