Metal-free synthesis of carbamoylated dihydroquinolinones via cascade radical annulation of cinnamamides with oxamic acids

Organic & Biomolecular Chemistry, Год журнала: 2024, Номер 22(9), С. 1821 - 1833

Опубликована: Янв. 1, 2024

Metal-free synthesis of medicinally important carbamoylated dihydroquinolinones using readily available, cheap and environment-friendly materials with good to excellent yields.

Язык: Английский

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An Iron‐Catalyzed Three‐Component Radical Cascade Cyclization to Access Cyanoalkylsulfonyl Quinolino‐Quinazolinones

Advanced Synthesis & Catalysis, Год журнала: 2024, Номер 366(11), С. 2456 - 2460

Опубликована: Март 21, 2024

Abstract An iron(II)‐catalyzed cascade reaction, involving cyanoalkylsulfonylation and cyclization, has been devised to enable the synthesis of functionalized sulfonylated quinolino‐quinazolinone alkyl nitriles. This three‐component radical transformation exhibits excellent chemo‐ regioselectivity while functioning without need for external oxidizing or reducing agents. The cost‐effectiveness this catalytic system, together with its broad substrate application, which includes drug molecule derivatives, make approach efficient adaptable.

Язык: Английский

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Visible-Light-Promoted Iron(II)/Lewis Base Catalysis for the Alkylation of Morita–Baylis–Hillman Acetates Using Carboxylic Acids

Organic Letters, Год журнала: 2024, Номер unknown

Опубликована: Окт. 1, 2024

A novel photoinduced Fe(OTf)

Язык: Английский

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Anthraquinone Sulfonates as Water‐Soluble Photocatalysts: Synthetic Applications and Perspectives

ChemPhotoChem, Год журнала: 2025, Номер unknown

Опубликована: Май 4, 2025

Anthraquinone sulfonates are water‐soluble and cost‐effective photocatalysts that have been attracting increasing interest due to their unique features. Their sulfonate groups unlock the application of photoactive anthraquinone core in aqueous solution. Moreover, these readily available catalysts can engage with substrates through different activation modes, such as hydrogen atom transfer proton‐coupled electron events. However, date, reactivity has not fully explored further applications expected emerge. Herein, existing synthetic outlined future perspectives discussed.

Язык: Английский

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Persulfate-Promoted Carbamoylation/Cyclization of Alkenes: Synthesis of Amide-Containing Quinazolinones

Molecules, Год журнала: 2024, Номер 29(5), С. 997 - 997

Опубликована: Фев. 25, 2024

The incorporation of amide groups into biologically active molecules has been proven to be an efficient strategy for drug design and discovery. In this study, we present a simple practical method the synthesis amide-containing quinazolin-4(3H)-ones under transition-metal-free conditions. This is achieved through carbamoyl-radical-triggered cascade cyclization N3-alkenyl-tethered quinazolinones. Notably, carbamoyl radical generated in situ from oxidative decarboxylative process oxamic acids presence (NH4)2S2O8.

Язык: Английский

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Visible-light-induced cascade radical cyclization for the synthesis of amide-functionalized fused quinazolinones

Tetrahedron, Год журнала: 2024, Номер 159, С. 134027 - 134027

Опубликована: Май 8, 2024

Язык: Английский

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Acid-catalyzed radical tandem alkylation/cyclization of unactivated alkenes with ketones: Access to ketoalkyl-substituted quinazolinone derivatives

Tetrahedron, Год журнала: 2024, Номер 162, С. 134085 - 134085

Опубликована: Июнь 11, 2024

Язык: Английский

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Photocatalytic alkenes to ring-fused quinazolin-4(3H)-ones via proton-transfer shuttle using TFA

Tetrahedron, Год журнала: 2024, Номер 158, С. 133990 - 133990

Опубликована: Апрель 11, 2024

Язык: Английский

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Alkaloids from Mackinlaya species and synthetic mackinazolinone derivatives: An overview

Bioorganic & Medicinal Chemistry, Год журнала: 2024, Номер 117, С. 118018 - 118018

Опубликована: Ноя. 23, 2024

Язык: Английский

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