Applications of innovative synthetic strategies in anticancer drug Discovery: The Driving Force of new chemical reactions

Bioorganic & Medicinal Chemistry Letters, Год журнала: 2025, Номер 119, С. 130096 - 130096

Опубликована: Янв. 9, 2025

Язык: Английский

---

[3 + 2] Cycloaddition Reaction of Vinylsulfonium Salts with Hydrazonoyl Halides: Synthesis of Pyrazoles

The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(14), С. 10066 - 10076

Опубликована: Июль 2, 2024

An efficient [3 + 2] cycloaddition reaction between in situ generated nitrile imines from hydrazonoyl halides and vinylsulfonium salts is developed. The are demonstrated to be a new class of partner for conduct the reaction. process provides concise method construction pyrazole derivatives under mild conditions with broad substrate scope, good product yields, high regioselectivity.

Язык: Английский

---

Arylation of Diethyl Acetamidomalonate with Diaryliodonium Salts En Route to α-Arylglycines

The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(14), С. 9923 - 9928

Опубликована: Июль 1, 2024

Diethyl acetamidomalonate (DEAM) has been widely used for the synthesis of α-amino acids via C-alkylation under basic conditions followed by hydrolysis/decarboxylation. In contrast, C-arylation this reagent remains undeveloped. Herein, we report a novel strategy racemic α-arylglycines based on selective arylation DEAM with diaryliodonium salts mild, transition metal-free conditions. The reaction features good functional group tolerance and easy scalability is applicable to chemoselective C-H-modification arenes including approved drugs, thus enabling straightforward approach complex that would be challenging make otherwise.

Язык: Английский

---

Me₃SiBr-promoted cascade electrophilic thiocyanation/cyclization of ortho-alkynylanilines to synthesize indole derivatives

Organic & Biomolecular Chemistry, Год журнала: 2024, Номер 22(20), С. 4031 - 4035

Опубликована: Янв. 1, 2024

A Me 3 SiBr promoted cascade electrophilic thiocyanation/cyclization of ortho -alkynylanilines with the N -thiocyanatosuccinimide to afford 3-thiocyanatoindoles has been developed.

Язык: Английский

---

Exogenous Photocatalyst-Free Aryl Radical Generation from Diaryliodonium Salts and use in Metal-Catalyzed C–H Arylation

Chemical Communications, Год журнала: 2024, Номер 60(54), С. 6929 - 6932

Опубликована: Янв. 1, 2024

We demonstrate (1) detectable halogen bonding is not critical for enabling light-driven radical generation from diaryliodonium salts and (2) radicals generated by this route can be captured transition-metals C-H arylation reactions. These results are the first step toward developing new metal-catalyzed aryl couplings without exogenous photocatalysts.

Язык: Английский

---

Organophotoredox Pd‐Catalyzed C–H Arylation at Room Temperature using Diaryliodonium Salts

ChemPhotoChem, Год журнала: 2024, Номер unknown

Опубликована: Окт. 24, 2024

Abstract Direct functionalization of C−H bonds is the most expeditious strategy to build complexity into organic molecules. Unfortunately, Pd‐catalyzed arylation strategies require high temperatures and/or stoichiometric oxidants. The discovery metallaphotoredox in 2011 forged a new approach achieve metal catalyzed at room temperature. Since this discovery, reports still use explosive diazonium salts as aryl radical precursors. Alternatively, single report uses bench‐stable diaryliodonium salts, albeit with an Ir‐based photocatalyst. In study, we develop organophotoredox manifold that enables numerous N ‐aryl amide substrates. results present are expected revitalize temperature arylations wide‐ranging classes bonds.

Язык: Английский

---

Five-membered ring systems: With more than 1 N atom

Progress in heterocyclic chemistry, Год журнала: 2024, Номер unknown, С. 211 - 257

Опубликована: Янв. 1, 2024

Язык: Английский

---