Review of application of the I₂ and dimethyl sulfoxide combined reagent system to aryl methyl ketones for diverse transformations

Organic Chemistry Frontiers, Год журнала: 2024, Номер 11(9), С. 2665 - 2692

Опубликована: Янв. 1, 2024

The synthesis of small molecules and complex scaffolds is one the most important topics in organic synthesis.

Язык: Английский

---

I₂-DMSO-Mediated Construction of 2,3- and 2,4-Disubstituted Pyrimido[1,2-b]indazole Skeletons

The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(6), С. 3941 - 3953

Опубликована: Фев. 29, 2024

An efficient synthetic method for constructing 2,3- and 2,4-disubstituted pyrimidio[1,2-b]indazole skeletons through I2-DMSO-mediated substrate-controlled regioselective [4 + 2] cyclization is reported. The reaction conditions are mild, its operation simple, the substrate scope wide. More than 60 derivatives have been synthesized, providing a new methodology related molecules potentially enriching bioactive-molecule libraries.

Язык: Английский

---

Research progress of self-organized reaction networks for cascade reactions

Tetrahedron, Год журнала: 2024, Номер 166, С. 134210 - 134210

Опубликована: Авг. 27, 2024

Язык: Английский

---

I2–DMSO-mediated formal [3 + 1 + 2] synthesis of pyrimido[1,2-b]indazole using 1,4-dithiane-2,5-diol as a surrogate of ethylene

Tetrahedron Letters, Год журнала: 2025, Номер 156, С. 155453 - 155453

Опубликована: Янв. 9, 2025

Язык: Английский

---

Dearomatization of Aromatic Compounds: A Decade Review

Asian Journal of Organic Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Май 28, 2025

Abstract Dearomatization offers an efficient strategy for directly converting arenes into cyclic molecules. In this review, we discuss representative examples of dearomatization reactions through five modes: (1) radical dearomatization, (2) halofunctionalization‐dearomatization, in which three‐membered intermediates were frequently involved, (3) nucleophilic mainly about electron‐rich arenes, (4) oxidative and (5) reductive dearomatization. Compared to heteroarenes, simple benzene are more challenging participate reactions. recent years, fewer reports have focused on benzene. Heteroarenes, inherently or easily activated, tend undergo readily. This review highlights a decade progress including indoles, benzofurans, benzothiophenes, thiophenes, furans, naphthols, naphthalenes, quinolines, pyridines, nitrobenzenes, benzenes. It also analyzes their mechanisms strategies. We hope will aid future research field.

Язык: Английский

---

DMSO promoted catalyst-free oxidative C–N/C–O couplings towards synthesis of imidazoles and oxazoles

Organic & Biomolecular Chemistry, Год журнала: 2024, Номер 22(18), С. 3684 - 3692

Опубликована: Янв. 1, 2024

Dimethyl sulfoxide (DMSO)-promoted catalyst-free oxidative C–N coupling and C–O under oxidant-free conditions are outlined.

Язык: Английский

---

N-Benzylhydroxylamine as a novel synthetic block in “C1N1” embedding reaction via α-C(sp³)–H activation strategy

Chemical Communications, Год журнала: 2024, Номер 60(56), С. 7180 - 7183

Опубликована: Янв. 1, 2024

A novel process using N -benzylhydroxylamine hydrochloride as a “C1N1 synthon” in [2+2+1] cyclization for the construction of 1,2,5-trisubstituted imidazoles has been described first time.

Язык: Английский

---

I₂-promoted formal [3 + 1 + 1 + 1] cyclization to construct 5-cyano-1H-pyrazolo[3,4-b]pyridine using malononitrile as a C1 synthon

Organic Chemistry Frontiers, Год журнала: 2023, Номер 10(23), С. 5958 - 5964

Опубликована: Янв. 1, 2023

A novel [3 + 1 1] cyclization reaction for the synthesis of compounds based on a 5-cyano-1 H -pyrazolo[3,4- b ]pyridine skeleton from aryl methyl ketones, malononitrile and 5-aminopyrazoles has been established.

Язык: Английский

---

Advances in Self-Organized Total Synthesis of Natural Products

Chemical Communications, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

In this review, we account for the definition, delimitation, and categorization of self-organized total synthesis then elucidate a comprehensive understanding synthetic strategy based on our intensive explorations.

Язык: Английский

---

One-pot synthesis of 2,2′-biquinolines from aromatic amines using oxygen as an oxidant under metal-free conditions

Organic Chemistry Frontiers, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 14, 2024

We have developed an efficient method for the synthesis of unsymmetrical and symmetrical 2,2′-biquinolines under 55% HI-catalyzed conditions using oxygen as oxidant cheap readily available aromatic amines feedstocks in one pot.

Язык: Английский

---