One-pot synthesis of 2,2′-biquinolines from aromatic amines using oxygen as an oxidant under metal-free conditions DOI
Yunfeng Liao,

Hualan Gao,

Hongrui Qi

et al.

Organic Chemistry Frontiers, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 14, 2024

We have developed an efficient method for the synthesis of unsymmetrical and symmetrical 2,2′-biquinolines under 55% HI-catalyzed conditions using oxygen as oxidant cheap readily available aromatic amines feedstocks in one pot.

Language: Английский

Review of application of the I2 and dimethyl sulfoxide combined reagent system to aryl methyl ketones for diverse transformations DOI
Dongsheng Yang, Xiang‐Long Chen, An‐Xin Wu

et al.

Organic Chemistry Frontiers, Journal Year: 2024, Volume and Issue: 11(9), P. 2665 - 2692

Published: Jan. 1, 2024

The synthesis of small molecules and complex scaffolds is one the most important topics in organic synthesis.

Language: Английский

Citations

19
I2-DMSO-Mediated Construction of 2,3- and 2,4-Disubstituted Pyrimido[1,2-b]indazole Skeletons DOI
Linlin Ma, You Zhou,

Yong‐Xing Tang

et al.

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(6), P. 3941 - 3953

Published: Feb. 29, 2024

An efficient synthetic method for constructing 2,3- and 2,4-disubstituted pyrimidio[1,2-b]indazole skeletons through I2-DMSO-mediated substrate-controlled regioselective [4 + 2] cyclization is reported. The reaction conditions are mild, its operation simple, the substrate scope wide. More than 60 derivatives have been synthesized, providing a new methodology related molecules potentially enriching bioactive-molecule libraries.

Language: Английский

Citations

6
Research progress of self-organized reaction networks for cascade reactions DOI

Yong‐Xing Tang,

An‐Xin Wu

Tetrahedron, Journal Year: 2024, Volume and Issue: 166, P. 134210 - 134210

Published: Aug. 27, 2024

Language: Английский

Citations

4
I2–DMSO-mediated formal [3 + 1 + 2] synthesis of pyrimido[1,2-b]indazole using 1,4-dithiane-2,5-diol as a surrogate of ethylene DOI

Yong-Dong Du,

Jungang Wang, Jinyi Liu

et al.

Tetrahedron Letters, Journal Year: 2025, Volume and Issue: 156, P. 155453 - 155453

Published: Jan. 9, 2025

Language: Английский

Citations

0
Dearomatization of Aromatic Compounds: A Decade Review DOI
Jianmin Chen, Wenhao Zhang, Dayun Huang

et al.

Asian Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: May 28, 2025

Abstract Dearomatization offers an efficient strategy for directly converting arenes into cyclic molecules. In this review, we discuss representative examples of dearomatization reactions through five modes: (1) radical dearomatization, (2) halofunctionalization‐dearomatization, in which three‐membered intermediates were frequently involved, (3) nucleophilic mainly about electron‐rich arenes, (4) oxidative and (5) reductive dearomatization. Compared to heteroarenes, simple benzene are more challenging participate reactions. recent years, fewer reports have focused on benzene. Heteroarenes, inherently or easily activated, tend undergo readily. This review highlights a decade progress including indoles, benzofurans, benzothiophenes, thiophenes, furans, naphthols, naphthalenes, quinolines, pyridines, nitrobenzenes, benzenes. It also analyzes their mechanisms strategies. We hope will aid future research field.

Language: Английский

Citations

0
DMSO promoted catalyst-free oxidative C–N/C–O couplings towards synthesis of imidazoles and oxazoles DOI
Debasish Bera, Rajib Sarkar,

Tiyasa Dhar

et al.

Organic & Biomolecular Chemistry, Journal Year: 2024, Volume and Issue: 22(18), P. 3684 - 3692

Published: Jan. 1, 2024

Dimethyl sulfoxide (DMSO)-promoted catalyst-free oxidative C–N coupling and C–O under oxidant-free conditions are outlined.

Language: Английский

Citations

2
N-Benzylhydroxylamine as a novel synthetic block in “C1N1” embedding reaction via α-C(sp3)–H activation strategy DOI

Yong-Xing Tang,

You Zhou,

Hao-Xuan Wu

et al.

Chemical Communications, Journal Year: 2024, Volume and Issue: 60(56), P. 7180 - 7183

Published: Jan. 1, 2024

A novel process using N -benzylhydroxylamine hydrochloride as a “C1N1 synthon” in [2+2+1] cyclization for the construction of 1,2,5-trisubstituted imidazoles has been described first time.

Language: Английский

Citations

2
I2-promoted formal [3 + 1 + 1 + 1] cyclization to construct 5-cyano-1H-pyrazolo[3,4-b]pyridine using malononitrile as a C1 synthon DOI

Zhi‐Cheng Yu,

Xi Shen, You Zhou

et al.

Organic Chemistry Frontiers, Journal Year: 2023, Volume and Issue: 10(23), P. 5958 - 5964

Published: Jan. 1, 2023

A novel [3 + 1 1] cyclization reaction for the synthesis of compounds based on a 5-cyano-1 H -pyrazolo[3,4- b ]pyridine skeleton from aryl methyl ketones, malononitrile and 5-aminopyrazoles has been established.

Language: Английский

Citations

5
Advances in Self-Organized Total Synthesis of Natural Products DOI
Lisheng Wang, Jia‐Chen Xiang, An‐Xin Wu

et al.

Chemical Communications, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

In this review, we account for the definition, delimitation, and categorization of self-organized total synthesis then elucidate a comprehensive understanding synthetic strategy based on our intensive explorations.

Language: Английский

Citations

1
One-pot synthesis of 2,2′-biquinolines from aromatic amines using oxygen as an oxidant under metal-free conditions DOI
Yunfeng Liao,

Hualan Gao,

Hongrui Qi

et al.

Organic Chemistry Frontiers, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 14, 2024

We have developed an efficient method for the synthesis of unsymmetrical and symmetrical 2,2′-biquinolines under 55% HI-catalyzed conditions using oxygen as oxidant cheap readily available aromatic amines feedstocks in one pot.

Language: Английский

Citations

0