Polymers,
Год журнала:
2025,
Номер
17(5), С. 558 - 558
Опубликована: Фев. 20, 2025
(1)
Background:
This
review
study
will
delve
into
the
potential
of
chitosan
nanoparticles
(NPs)
as
adaptable
carriers
for
targeted
drug
delivery
in
different
therapeutic
areas.
Chitosan
is
a
biopolymer
derived
from
chitin
that
has
attracted
interest
applications
because
its
high
biocompatibility
and
biodegradability.
(2)
Methods:
A
comprehensive
literature
was
conducted
by
following
careful
systematized
protocol
searching
databases
like
PubMed,
Google
Scholar
ScienceDirect.
(3)
Results:
NPs
are
good
vehicles,
notably
cancer.
Studies
reveal
doxorubicin-loaded
dramatically
enhance
toxicity
to
tumor
cells
compared
free
medicines,
yielding
suppression
rates
up
60%.
Researchers
found
chemotherapeutics
had
an
85%
encapsulation
efficiency
(EE),
lowering
systemic
toxicity.
Magnetic
pH-responsive
boost
accumulation
63%
apoptosis
54%.
also
boosts
medication
retention
lungs
2.3×,
per
pulmonary
trials.
ocular
bioavailability
3×
improve
nasal
absorption
30%,
crossing
blood-brain
barrier.
For
bone
regeneration,
scaffolds
mineral
density
46%,
facilitating
osteogenesis
healing.
(4)
Conclusions:
made
provide
solid
foundation
improving
systems;
yet
there
still
issues
with
material
variability,
scalability,
meeting
regulatory
requirements
need
fixing.
Research
combination
treatments,
ways
increase
their
specificity,
optimize
these
offers
promising
prospects
creation
novel
approaches
patient
outcomes.
Gels,
Год журнала:
2024,
Номер
10(4), С. 216 - 216
Опубликована: Март 22, 2024
Hydrogels,
being
hydrophilic
polymer
networks
capable
of
absorbing
and
retaining
aqueous
fluids,
hold
significant
promise
in
biomedical
applications
owing
to
their
high
water
content,
permeability,
structural
similarity
the
extracellular
matrix.
Recent
chemical
advancements
have
bolstered
versatility,
facilitating
integration
molecules
guiding
cellular
activities
enabling
controlled
activation
under
time
constraints.
However,
conventional
synthetic
hydrogels
suffer
from
inherent
weaknesses
such
as
heterogeneity
network
imperfections,
which
adversely
affect
mechanical
properties,
diffusion
rates,
biological
activity.
In
response
these
challenges,
hybrid
emerged,
aiming
enhance
strength,
drug
release
efficiency,
therapeutic
effectiveness.
These
hydrogels,
featuring
improved
formulations,
are
tailored
for
tissue
regeneration
across
both
soft
hard
tissues.
The
scientific
community
has
increasingly
recognized
versatile
characteristics
particularly
sector.
This
comprehensive
review
delves
into
recent
hydrogel
systems,
covering
diverse
types,
modification
strategies,
nano/microstructures.
discussion
includes
innovative
fabrication
techniques
click
reactions,
3D
printing,
photopatterning
alongside
elucidation
mechanisms
bioactive
molecules.
By
addressing
underscores
envisages
a
promising
future
various
domains
field.
Polymers,
Год журнала:
2024,
Номер
16(6), С. 843 - 843
Опубликована: Март 19, 2024
Chemotherapy
together
with
surgery
and/or
radiotherapy
are
the
most
common
therapeutic
methods
for
treating
cancer.
However,
off-target
effects
of
chemotherapy
known
to
produce
side
and
dose-limiting
toxicities.
Novel
delivery
platforms
based
on
natural
synthetic
polymers
enhanced
pharmacokinetic
potential
treatment
cancer
have
grown
tremendously
over
past
10
years.
Polymers
can
facilitate
selective
targeting,
enhance
prolong
circulation,
improve
delivery,
provide
controlled
release
cargos
through
various
mechanisms,
including
physical
adsorption,
chemical
conjugation,
internal
loading.
Notably,
that
biodegradable,
biocompatible,
physicochemically
stable
considered
be
ideal
carriers.
This
biomimetic
bio-inspired
system
offers
a
bright
future
effective
drug
overcome
obstacles
encountered.
review
focuses
barriers
impact
success
as
well
recent
developments
improving
Green Processing and Synthesis,
Год журнала:
2024,
Номер
13(1)
Опубликована: Янв. 1, 2024
Abstract
Materials-based
drug
delivery
approaches
have
garnered
substantial
attention
in
recent
years
due
to
their
potential
revolutionize
pharmaceutical
interventions.
This
abstract
provides
a
concise
overview
of
advancements
and
future
prospects
this
rapidly
evolving
field.
Materials
such
as
nanoparticles,
liposomes,
polymers,
hydrogels
emerged
versatile
carriers
for
delivery.
These
materials
facilitate
precise
control
over
release
kinetics,
enabling
targeted
sustained
therapeutic
effects.
Smart
with
responsiveness
external
stimuli
or
physiological
conditions
further
enhanced
precision.
Personalized
medicine
are
gaining
traction,
tailoring
systems
individual
patient
profiles
needs.
The
horizon
materials-based
is
bright.
Ongoing
research
focused
on
refining
material
design,
streamlining
production
processes,
ensuring
safety
profiles.
Collaborative
efforts
among
researchers,
clinicians,
industry
stakeholders
crucial
translating
these
into
clinical
practice.
Additionally,
the
convergence
diagnostics
imaging
holds
immense
personalized
efficient
healthcare
solutions.
As
continues
evolve,
it
stands
poised
reshape
landscape
pharmaceuticals,
offering
promise
more
effective
patient-centered
therapies
wide
range
medical
conditions.
Energy & Fuels,
Год журнала:
2024,
Номер
38(3), С. 1593 - 1617
Опубликована: Янв. 16, 2024
This
review
illuminates
the
pivotal
synergy
between
machine
learning
(ML)
and
biopolymers,
spotlighting
their
combined
potential
to
reshape
sustainable
energy,
fuels,
biochemicals.
Biobased
polymers,
derived
from
renewable
sources,
have
garnered
attention
for
roles
in
energy
fuel
sectors.
These
when
integrated
with
ML
techniques,
exhibit
enhanced
functionalities,
optimizing
systems,
storage,
conversion.
Detailed
case
studies
reveal
of
biobased
polymers
applications
industry,
further
showcasing
how
bolsters
efficiency
innovation.
The
intersection
also
marks
advancements
biochemical
production,
emphasizing
innovations
drug
delivery
medical
device
development.
underscores
imperative
harnessing
convergence
future
global
sustainability
endeavors
collective
evidence
presented
asserts
immense
promise
this
union
holds
steering
a
innovative
trajectory.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(3), С. 1720 - 1720
Опубликована: Янв. 31, 2024
Measures
to
endorse
the
adoption
of
eco-friendly
biodegradable
plastics
as
a
response
scale
plastic
pollution
has
created
demand
for
innovative
products
from
materials
Nature.
Ionic
liquids
(ILs)
have
ability
disrupt
hydrogen
bonding
network
biopolymers,
increase
mobility
biopolymer
chains,
reduce
friction,
and
produce
with
various
morphologies
mechanical
properties.
Due
these
qualities,
ILs
are
considered
ideal
plasticizing
enabling
them
meet
wide
range
specifications
biopolymeric
materials.
This
mini-review
discusses
effect
different
IL-plasticizers
on
processing,
tensile
strength,
elasticity
made
biopolymers
(e.g.,
starch,
chitosan,
alginate,
cellulose),
specifically
covers
IL-plasticized
packaging
biomedical
electrochemical
applications.
Furthermore,
challenges
(cost,
scale,
eco-friendliness)
future
research
directions
in
IL-based
plasticizers
discussed.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(6), С. 3133 - 3133
Опубликована: Март 8, 2024
The
increasing
demand
for
innovative
approaches
in
wound
healing
and
skin
regeneration
has
prompted
extensive
research
into
advanced
biomaterials.
This
review
focuses
on
showcasing
the
unique
properties
of
sustainable
silk-based
particulate
systems
promoting
controlled
release
pharmaceuticals
bioactive
agents
context
regeneration.
Silk
fibroin
sericin
are
derived
from
well-established
silkworm
production
constitute
a
biocompatible
biodegradable
protein
platform
development
drug
delivery
systems.
therapeutic
compounds
not
only
ensures
optimal
bioavailability
but
also
addresses
challenges
associated
with
conventional
methods.
multifaceted
benefits
silk
proteins,
including
their
inherent
biocompatibility,
versatility,
sustainability,
explored
this
review.
Furthermore,
intricate
mechanisms
by
which
takes
place
carriers
discussed.
There
is
ongoing
research
for
biomedical
applications
of
polyvinyl
alcohol
(PVA)-based
hydrogels;
however,
the
execution
this
has
not
yet
been
achieved
at
an
appropriate
level
commercialization.
Advanced
perception
necessary
design
and
synthesis
suitable
materials,
such
as
PVA-based
hydrogel
applications.
Among
polymers,
drawn
great
interest
in
owing
to
their
attractive
potential
with
characteristics
good
biocompatibility,
mechanical
strength,
apposite
water
content.
By
designing
approach
investigating
structure,
hydrogels
can
attain
superb
cytocompatibility,
flexibility,
antimicrobial
activities,
signifying
that
it
a
candidate
tissue
engineering
regenerative
medicine,
drug
delivery,
wound
dressing,
contact
lenses,
other
fields.
In
review,
we
highlight
current
progresses
on
explaining
diverse
usage
across
variety
areas.
We
explain
numerous
techniques
related
phenomena
based
these
materials.
This
review
may
stipulate
wide
reference
future
acumens
materials
extensive
