Curcumin-loaded polymeric nanomaterials as a novel therapeutic strategy for Alzheimer's disease: A comprehensive review
Ageing Research Reviews,
Год журнала:
2024,
Номер
99, С. 102393 - 102393
Опубликована: Июнь 24, 2024
Язык: Английский
Expanding the boundaries of silk sericin biomaterials in biomedical applications
Journal of Materials Chemistry B,
Год журнала:
2024,
Номер
12(29), С. 7020 - 7040
Опубликована: Янв. 1, 2024
Unlock
the
potential
of
silk
sericin
(SS)
in
bioengineering.
From
its
origins
to
market
evolution,
explore
diverse
applications
and
future
prospects.
Язык: Английский
Silk Protein Gene Engineering and Its Applications: Recent Advances in Biomedicine Driven by Molecular Biotechnology
Drug Design Development and Therapy,
Год журнала:
2025,
Номер
Volume 19, С. 599 - 626
Опубликована: Янв. 1, 2025
Silk
protein,
as
a
natural
polymer
material
with
unique
structures
and
properties,
exhibits
tremendous
potential
in
the
biomedical
field.
Given
limited
production
restricted
properties
of
silk
proteins,
molecular
biotechnology
has
been
extensively
applied
protein
genetic
engineering
to
produce
novel
proteins
specific
properties.
This
review
outlines
roles
major
model
organisms,
such
silkworms
spiders,
production,
provides
detailed
introduction
applications
gene
editing
technologies
(eg,
CRISPR-Cas9),
transgenic
expression
technologies,
synthetic
biology
techniques
engineering.
By
analyzing
factors
influencing
expression,
this
further
elaborates
on
innovative
drug
delivery
systems,
tissue
regenerative
medicine
skin,
bone,
cartilage,
vascular
repair),
well
antibacterial
immune
strategies.
Notably,
modified
expressed
by
demonstrate
significant
advantages
enhancing
bioavailability
promoting
cell
proliferation
differentiation.
In
conclusion,
engineering,
through
continuous
innovations
biotechnology,
provided
an
effective
pathway
for
high-performance
materials.
The
extensive
these
field
have
not
only
expanded
functionality
but
also
offered
new
approaches
address
medical
challenges.
future,
development
will
rely
interdisciplinary
integration
promote
in-depth
research
expansion
industrial
proteins.
Язык: Английский
Innovative Processing and Sterilization Techniques to Unlock the Potential of Silk Sericin for Biomedical Applications
Gels,
Год журнала:
2025,
Номер
11(2), С. 114 - 114
Опубликована: Фев. 6, 2025
Silk
sericin
(SS),
a
by-product
of
the
textile
industry,
has
gained
significant
attention
for
its
biomedical
potential
due
to
biocompatibility
and
regenerative
potential.
However,
literature
lacks
information
on
SS
processing
methods
resulting
physicochemical
properties.
This
study
represents
first
step
in
protocol
optimization
standardization.
In
present
work,
different
techniques
were
studied
compared
extracted
from
boiling
water:
evaporation,
rotary
lyophilization,
dialysis,
which
presented
recovery
yield
approximately
27–32%.
The
goal
was
find
most
promising
process
concentrate
solutions,
ensure
that
structure
highly
preserved.
As
result,
new
cryo-lyophilization
methodology
proposed.
proposed
method
allows
preservation
amorphous
structure,
offers
advantages
including
complete
dissolution
water
PBS,
an
increase
storage
stability,
possibility
scaling-up,
making
it
suitable
industrial
applications.
second
part
work
focused
addressing
another
challenge
processing:
efficient
non-destructive
sterilization.
Supercritical
CO2
(scCO2)
been
gaining
momentum
last
years
sterilizing
sensitive
biopolymers
biological
materials
non-toxicity
mild
conditions.
Thus,
scCO2
technology
validated
as
technique
terminal
sterilization
SS.
this
way,
possible
engineer
sequential
cryo-lyophilization/scCO2
able
preserve
original
properties
natural
silk
protein.
Overall,
we
have
valorized
into
sterile,
off-the-shelf,
bioactive,
water-soluble
material,
with
be
used
biomedical,
pharmaceutical,
or
cosmetic
industries.
Язык: Английский
Pathogenetic association of inflammation and hemostasis markers in the blood of patients with injuries of large joints
TRAUMA,
Год журнала:
2025,
Номер
26(1), С. 1 - 10
Опубликована: Март 7, 2025
Background.
In
patients
with
injuries
of
large
joints,
the
activation
inflammation
causes
risk
thrombophilia.
The
prediction
thrombotic
complications
and
their
prevention
can
improve
quality
treatment.
purpose:
to
investigate
data
scientific
medical
literature
on
pathogenetic
association
between
markers
hemostasis
in
degenerative
diseases
post-traumatic
joints.
Materials
methods.
search
for
has
been
made
PubMed
database
10
years.
Sixty
works
were
selected.
Results.
A
total
60
papers
selected
analysis.
They
recorded
information
about
relationship
mechanisms
hypercoagulability
trauma.
specified
are
given
this
work.
Conclusions.
orthopedics
traumatology,
considerable
attention
is
paid
surgical
treatment
trauma,
particular,
Individuals
trauma
or
surgery
joints
have
a
correlation
biochemical
common
clinical
inflammation,
metabolism
glycoproteins,
proteoglycans
collagen
laboratory
indicators
hemostasis.
case,
significant
damage
formation
vicious
circle
observed:
decrease
plasminogen
content,
which
under
action
activators
converted
plasmin,
trigger
factor
fibrinolytic
system,
that
at
same
time
activity
acceleration
dystrophic
processes
accumulation
blood
serum
an
excessive
amount
acute
phase
glycoproteins.
addition,
there
increase
plasma
following
coagulation
markers:
fibrinogen,
soluble
fibrin
monomer
complexes,
D-dimers,
inflammatory
such
as
C-reactive
protein,
haptoglobin.
From
this,
it
follows
postoperative
requires
timely
monitoring
markers,
well
measures
prevent
thrombophilia,
including
prehospital
stage.
Язык: Английский
Silk fibroin: An innovative protein macromolecule-based hydrogel/scaffold revolutionizing breast cancer treatment and diagnosis – Mechanisms, advancements, and targeting capabilities
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
unknown, С. 142870 - 142870
Опубликована: Апрель 1, 2025
Язык: Английский
Silk-based intelligent fibers and textiles: Structures, properties, and applications
Chemical Communications,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
This
review
summarizes
the
hierarchical
structure
and
multifaceted
properties
of
natural
silk
fibers,
provides
an
in-depth
analysis
their
extensive
applications
in
realms
biomedicine
advanced
smart
fiber
technology.
Язык: Английский
Multifunctional hydrogel dressing promotes wound healing by reprogramming the infection-related wound microenvironment
Journal of Materials Science,
Год журнала:
2024,
Номер
59(35), С. 16660 - 16677
Опубликована: Сен. 1, 2024
Язык: Английский
Trends in Protein Derived Materials for Wound Care Applications
Biomaterials Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 1, 2024
Natural
resource
based
polymers,
especially
those
derived
from
proteins,
have
attracted
significant
attention
for
their
potential
utilization
in
advanced
wound
care
applications.
Protein
materials
provide
superior
biocompatibility,
biodegradability,
and
other
functionalities
compared
to
conventional
dressings.
The
effectiveness
of
various
fabrication
techniques,
such
as
electrospinning,
phase
separation,
self-assembly,
ball
milling,
is
examined
the
context
developing
protein-based
healing.
These
methods
produce
a
wide
range
forms,
including
hydrogels,
scaffolds,
sponges,
films,
bioinspired
nanomaterials,
each
designed
specific
types
wounds
different
stages
This
review
presents
comprehensive
analysis
recent
research
that
investigates
transformation
proteins
into
healing
Our
focus
on
essential
keratin,
collagen,
gelatin,
silk,
zein,
albumin,
we
emphasize
distinct
traits
roles
management.
Protein-based
show
promising
biomedical
engineering,
offering
improved
capabilities
reduced
risks
infection.
It
crucial
explore
use
these
clinical
settings
while
also
addressing
challenges
may
arise
commercialization
future.
Язык: Английский
Organic–Inorganic Hybridization of Silkworm Cocoon Filaments Using Nano Pastes of Silica–Phosphate–M (M = Cu, Fe, or Al)
Nanomaterials,
Год журнала:
2024,
Номер
14(21), С. 1697 - 1697
Опубликована: Окт. 23, 2024
Inorganic-organic
hybrid
biomaterials
have
recently
attracted
much
attention
because
of
their
widespread
use.
Silkworm
cocoon
filaments
resulting
from
sericulture
as
prospective
nanobiomaterials
need
to
be
improved,
and
properties
used
for
broader
purposes.
This
study
was
aimed
at
investigating
methods
siliconization
silkworm
characterizing
filament
in
terms
yarn
quality,
natural
dyeing,
antibacterial
properties.
Three
hybridization
processes
were
this
experiment,
namely,
situ
dyeing
silk
yarns
while
spined,
feed
engineering
through
spraying
the
mulberry
leaves
with
dyes
silica-phosphate-M
(M
=
Cu,
Fe,
or
Al)
nano
pastes,
a
combination
both
methods.
The
characterized
by
fibers
using
FTIR,
XRD,
SEM-EDS
tensile
strength,
color
fastness
affected
fibers,
also
investigated.
Results
showed
that
method
produced
better
and,
consequently,
well
yarns.
Язык: Английский