Stimuli‐Responsive 3D Printable Conductive Hydrogel: A Step toward Regulating Macrophage Polarization and Wound Healing DOI
Jieun Lee, Sayan Deb Dutta,

Rumi Acharya

et al.

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 13(4)

Published: Nov. 11, 2023

Abstract Conductive hydrogels (CHs) are promising alternatives for electrical stimulation of cells and tissues in biomedical engineering. Wound healing immunomodulation complex processes that involve multiple cell types signaling pathways. 3D printable conductive have emerged as an innovative approach to promote wound modulate immune responses. CHs can facilitate mechanical stimuli, which be beneficial altering cellular metabolism enhancing the efficiency delivery therapeutic molecules. This review summarizes recent advances their effect on macrophage polarization. report also discusses properties various materials used fabricate stimulate Furthermore, this highlights challenges limitations using future material discovery. Overall, hold excellent potential accelerating responses, lead development new strategies skin immune‐related diseases.

Language: Английский

Injectable Antiswelling and High-Strength Bioactive Hydrogels with a Wet Adhesion and Rapid Gelling Process to Promote Sutureless Wound Closure and Scar-free Repair of Infectious Wounds DOI
Xin Zhao,

Jinlong Luo,

Ying Huang

et al.

ACS Nano, Journal Year: 2023, Volume and Issue: 17(21), P. 22015 - 22034

Published: Oct. 20, 2023

Developing injectable antiswelling and high-strength bioactive hydrogels with wet tissue adhesiveness a rapid gelling process to meet the requirements for hemostasis, sutureless wound closure, scar-free repair of infected skin wounds continues have ongoing challenges. Herein, injectable, antibacterial, antioxidant hydrogel adhesives based on poly(citric acid-co-polyethylene glycol)-g-dopamine amino-terminated Pluronic F127 (APF) micelles loaded astragaloside IV (AS) are prepared. The H2O2/horseradish peroxidase (HRP) system is used cause cross-linking network through oxidative coupling between catechol groups chemical group amino group. exhibit process, high mechanical strength, an effect, good property, H2O2 release behavior, degradability. In addition, present adhesiveness, bursting pressure, excellent antibacterial activity, long-term sustained AS, biocompatibility. perform hemostasis mouse liver, rat rabbit femoral vein bleeding models achieve much better closure healing incisions than biomedical glue surgical sutures. Furthermore, dressing significantly improved MRSA-infected full thickness defect by modulating inflammation, regulating ratio collagen I/III, improving vascularization granulation formation. Thus, AS-loaded show huge potential as multifunctional dressings in vivo wounds.

Language: Английский

Citations

92
Photothermal antibacterial antioxidant conductive self-healing hydrogel with nitric oxide release accelerates diabetic wound healing DOI
Jiahui He, Zhenlong Li,

Jiaxin Wang

et al.

Composites Part B Engineering, Journal Year: 2023, Volume and Issue: 266, P. 110985 - 110985

Published: Sept. 9, 2023

Language: Английский

Citations

84
Wound management materials and technologies from bench to bedside and beyond DOI
Canran Wang, Ehsan Shirzaei Sani, Chia-Ding Shih

et al.

Nature Reviews Materials, Journal Year: 2024, Volume and Issue: 9(8), P. 550 - 566

Published: June 17, 2024

Language: Английский

Citations

79
Supramolecular hydrogels for wound repair and hemostasis DOI

Shaowen Zhuo,

Yongping Liang,

Zhengying Wu

et al.

Materials Horizons, Journal Year: 2023, Volume and Issue: 11(1), P. 37 - 101

Published: Oct. 27, 2023

The unique network characteristics and stimuli responsiveness of supramolecular hydrogels have rendered them highly advantageous in the field wound dressings, showcasing unprecedented potential. However, there are few reports on a comprehensive review hydrogel dressings for repair hemostasis. This first introduces major cross-linking methods hydrogels, which includes hydrogen bonding, electrostatic interactions, hydrophobic host-guest metal ligand coordination some other interactions. Then, we advanced materials reported recent years then summarize basic principles each method. Next, classify structures before outlining their forming process propose potential future directions. Furthermore, also discuss raw materials, structural design principles, material used to achieve functions such as antibacterial function, tissue adhesion, substance delivery, anti-inflammatory antioxidant functions, cell behavior regulation, angiogenesis promotion, hemostasis innovative years. Finally, existing problems well development directions strategy, design, discussed. is proposed stimulate further exploration by researchers future.

Language: Английский

Citations

52
A Conductive and Adhesive Hydrogel Composed of MXene Nanoflakes as a Paintable Cardiac Patch for Infarcted Heart Repair DOI
Mingyu Lee,

Junggeon Park,

Goeun Choe

et al.

ACS Nano, Journal Year: 2023, Volume and Issue: 17(13), P. 12290 - 12304

Published: June 20, 2023

Myocardial infarction (MI) is a major cause of death worldwide. After the occurrence MI, heart frequently undergoes serious pathological remodeling, leading to excessive dilation, electrical disconnection between cardiac cells, and fatal functional damage. Hence, extensive efforts have been made suppress remodeling promote repair infarcted heart. In this study, we developed hydrogel patch that can provide mechanical support, conduction, tissue adhesiveness aid in recovery an function. Specifically, conductive adhesive (CAH) by combining two-dimensional titanium carbide (Ti3C2Tx) MXene with natural biocompatible polymers [i.e., gelatin dextran aldehyde (dex-ald)]. The CAH was formed within 250 s mixing precursor solution could be painted. containing 3.0 mg/mL MXene, 10% gelatin, 5% dex-ald exhibited appropriate material characteristics for applications, including uniform distribution high conductivity (18.3 mS/cm), tissue-like elasticity (30.4 kPa), strong adhesion (6.8 resistance various deformations. cytocompatible induced cardiomyocyte (CM) maturation vitro, as indicated upregulation connexin 43 expression faster beating rate. Furthermore, painted onto remained stably adhered epicardium. vivo animal studies revealed treatment significantly improved function alleviated Thus, believe our MXene-based potentially serve promising platform effective electroactive tissues heart, muscle, nerve tissues.

Language: Английский

Citations

49
Hydrogel-based dressings designed to facilitate wound healing DOI Creative Commons
Wei Zhang, Lulu Liu, Hui Cheng

et al.

Materials Advances, Journal Year: 2023, Volume and Issue: 5(4), P. 1364 - 1394

Published: Dec. 20, 2023

This review provides an overview of the functionalities hydrogel-based dressings and their role in promoting wound healing.

Language: Английский

Citations

43
Conductive Hyaluronic Acid/Deep Eutectic Solvent Composite Hydrogel as a Wound Dressing for Promoting Skin Burn Healing Under Electrical Stimulation DOI
Yu Tian, Fei Jiang, Haijiao Xie

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(17)

Published: April 3, 2024

Abstract Burns can cause severe damage to the skin due bacterial infection and inflammation. Although conductive hydrogels as electroactive burn‐wound dressings achieve remarkable effects on accelerating wound healing, issues such imbalance between their high conductivity mechanical properties, easy dehydration, low transparency must be addressed. Herein, a double‐network eutectogel is fabricated by integrating polymerizable deep eutectic solvents (PDESs)including acrylamide/choline chloride/glycerol (acrylamide‐polymerization crosslink) thiolated hyaluronic acid (disulfide‐bonding crosslink). The introduction of PDESs provides with (up 0.25 S·m −1 ) strength (tensile strain 59–77%) simulating those natural human skin, well satisfactory tissue adhesiveness, self‐healing ability, antibacterial properties. When combined exogenous electrical stimulation, exhibits ability reduce inflammation, stimulate cell proliferation migration, promote collagen deposition angiogenesis, facilitate remodeling. This shows great potential dressing for healing major burn wounds.

Language: Английский

Citations

22
Advances in electroactive biomaterials: Through the lens of electrical stimulation promoting bone regeneration strategy DOI Creative Commons
Songyang Luo, Chengshuo Zhang, Wei Xiong

et al.

Journal of Orthopaedic Translation, Journal Year: 2024, Volume and Issue: 47, P. 191 - 206

Published: June 27, 2024

The regenerative capacity of bone is indispensable for growth, given that accidental injury almost inevitable. Bone relevant the aging population globally and repair large defects after osteotomy (e.g., following removal malignant tumours). Among many therapeutic modalities proposed to regeneration, electrical stimulation has attracted significant attention owing its economic convenience exceptional curative effects, various electroactive biomaterials have emerged. This review summarizes current knowledge progress regarding strategies improving repair. Such range from traditional methods delivering via electroconductive materials using external power sources self-powered biomaterials, such as piezoelectric nanogenerators. Electrical osteogenesis are related piezoelectricity. examines cell behaviour potential mechanisms electrostimulation in healing, aiming provide new insights regeneration biomaterials. roles rehabilitating microenvironment facilitate addressing whereby cues mediate regeneration. Interactions between osteogenesis-related cells summarized, leading proposals use stimulation-based therapies accelerate healing.

Language: Английский

Citations

20
Polymer ionogels and their application in flexible ionic devices DOI Creative Commons

Jinqiao Wen,

Lei Zhou, Tengling Ye

et al.

SmartMat, Journal Year: 2024, Volume and Issue: 5(2)

Published: Jan. 2, 2024

Abstract Polymer ionogel (PIG) is a new type of flexible, stretchable, and ion‐conductive material, which generally consists two components (polymer matrix materials ionic liquids/deep eutectic solvents). More more attention has been received owing to its excellent properties, such as nonvolatility, good conductivity, thermal stability, high electrochemical transparency. In this review, the latest research developments PIGs are comprehensively reviewed according different polymer matrices. Particularly, development novel structural designs, preparation methods, basic their advantages respectively summarized. Furthermore, typical applications in flexible skin, electrochromic devices, actuators, power supplies reviewed. The working mechanism, device structure design strategies, unique functions PIG‐based devices briefly introduced. Finally, perspectives on current challenges future directions application discussed.

Language: Английский

Citations

19
3D Engineered scaffolds of conjugated polymers/metal organic frameworks for biomedical applications DOI

Amin Hosseini Sharifabad,

Roham Ghanbari, Mohammad Reza Saeb

et al.

International Materials Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 3, 2025

The extracellular matrix can be replicated by 3D scaffolds, providing a favorable environment for cell growth, proliferation, and differentiation. Despite their biocompatibility, biodegradability, bioactivity, the poor mechanical strength of scaffolds limits use heavy loads. This creates bottleneck in supply with enhanced all previously mentioned characteristics. Conjugated polymers have emerged as promising option scaffold construction due to electrical conductivity, adjustable surface qualities, ability transfer bioactive molecules. Moreover, metal-organic frameworks (MOFs) are rapidly emerging class nanomaterials uniform porosity, excellent surface-to-volume ratio, variable diverse configurations, well tuanble chemical structures. While both conjugated polymer-based MOF-based suffer from drawbacks such low stability possible toxicity, combination is an imperative strategy construct desirable scaffols biomedical applications. Specific examples investigated polymer-MOF provided each area, along explanation synthesis, fabrication method, physicochemical properties. Finally, applications polymers/MOF tissue engineering cancer theragnostic reviewed, current challenges potential future directions discussed.

Language: Английский

Citations

3