Engineered Cell‐Derived Nanovesicles with CAR and PH20 for Enhanced Targeted Photodynamic Cancer Therapy and Tumor Microenvironment Modulation DOI Open Access
Hongjun Oh,

Gye Ryeol Park,

Jieun Han

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 31, 2024

Abstract Photodynamic therapy (PDT) is a promising cancer treatment, but its clinical use limited by nontargeted photosensitizers (PS) that accumulate in normal tissues, causing adverse effects, and poor penetration tumor tissues due to the dense extracellular matrix (ECM). Here an innovative approach presented using cell‐derived nanovesicles (CNVs) engineered with chimeric antigen receptor (CAR) hyaluronidase PH20 enhance targeted PDT. The CAR–PH20 CNVs, loaded photosensitizer pheophorbide (PheoA), specifically target HER2‐expressing cells degrade hyaluronic acid microenvironment (TME), improving drug distribution. In vitro vivo experiments demonstrate increased reactive oxygen species (ROS) generation, improved retention, enhanced therapeutic efficacy compared conventional methods. When combined laser irradiation, these CNVs induce significant cell apoptosis inhibit growth mouse models, while minimizing toxicity tissues. This platform offers strategy for targeted, TME‐modulating PDT efficacy, reduced side marking advance nanodrug‐based therapies.

Language: Английский

Phototherapy: progress, challenges, and opportunities DOI
Xi Yuan,

Junliang Zhou,

Lin Yuan

et al.

Science China Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 5, 2024

Language: Английский

Citations

10
Smart fluorogenic tools: From designing principles to visualization of multistep protein aggregation DOI

Jingyang Wan,

Chen‐Yang Huang, Ziyue Chen

et al.

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 535, P. 216625 - 216625

Published: March 19, 2025

Language: Английский

Citations

0
Synthesis and performance research of an AIE molecule DOI

Yuehua Liang,

Jiuzhi Wei,

Juan Zhang

et al.

Journal of Photochemistry and Photobiology A Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 116420 - 116420

Published: April 1, 2025

Language: Английский

Citations

0
Electrochemiluminescence biosensor for the thyroid cancer biomarker miRNA-146b-5p detection using Zr-based metal-organic framework DOI
Meng Lu, Lingling Wang, Yuping Wei

et al.

Analytica Chimica Acta, Journal Year: 2025, Volume and Issue: unknown, P. 344025 - 344025

Published: April 1, 2025

Language: Английский

Citations

0
A Diketopyrrolopyrrole‐Based All‐in‐One Nanoplatform for Self‐Reinforcing Mild Photothermal Therapy Cascade Immunotherapy for Tumors DOI
Xinsheng Li, Lingyan Liu,

Kaini Yang

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(27)

Published: July 15, 2024

Abstract Mild photothermal therapy (PTT) has attracted attention for effectively avoiding the severe side effects associated with high‐temperature tumor ablation. However, its progress is hindered by limited availability of high‐performance agents (PTAs) and thermoresistance cancer cells induced heat shock reactions. Herein, this work proposes a new strategy to expand library organic small‐molecule PTAs utilize it construct multifunctional nano‐theranostic platform. By incorporating additional acceptors appropriate π‐bridges, diketopyrrolopyrrole‐based dye BDB developed, which exhibits strong absorption bright fluorescence emission in near‐infrared (NIR) region. Subsequently, co‐coated protein (HSP) inhibitor tanespimycin (17‐AAG) using functional amphiphilic polymers DSPE‐Hyd‐PEG 2000 ‐cRGD form an all‐in‐one nanoplatform BAG NPs. As result, NPs can precisely target tissue, guide treatment process real‐time through NIR‐II fluorescence/photoacoustic/photothermal imaging, release 17‐AAG on demand enhance mild PTT. Additionally, PTT been demonstrated induce immunogenic cell death (ICD) activate systemic anti‐tumor immune response, thereby suppressing both primary distant tumors. Overall, study presents designed precise combined immunotherapy effective treatment.

Language: Английский

Citations

3
Aggregation-Induced Emission: Application in Diagnosis and Therapy of Hepatocellular Carcinoma DOI

Wenjing Xu,

Danfeng Jian,

Yang Huang

et al.

Biosensors and Bioelectronics, Journal Year: 2024, Volume and Issue: 266, P. 116722 - 116722

Published: Aug. 29, 2024

Language: Английский

Citations

1
Supramolecular-platform-assisted selective recognition of uric acid with high sensitivity via microenvironment modulation of a self-assembled probe DOI
Saikat Samanta, Provakar Paul,

Chinmoy Mahapatra

et al.

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(38), P. 9545 - 9549

Published: Jan. 1, 2024

A supramolecular platform for uric acid recognition through a straightforward, resourceful technique under the tolerable physiological level.

Language: Английский

Citations

1
Cyano Positional Isomerism Strategy for Constructing Mitochondria-Targeted AIEgen with Type I Reactive Oxygen Species Generation Capability DOI
Jiabao Zhuang, Quan Pan, Chunli Zhou

et al.

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Based on the cyano positional isomerism strategy, a cationic AIEgen was developed, which can specifically stain mitochondria, and ablate cancer cells through potent type I photodynamic therapy both in vitro multicellular tumor spheroid models.

Language: Английский

Citations

1
Engineered Cell‐Derived Nanovesicles with CAR and PH20 for Enhanced Targeted Photodynamic Cancer Therapy and Tumor Microenvironment Modulation DOI Open Access
Hongjun Oh,

Gye Ryeol Park,

Jieun Han

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 31, 2024

Abstract Photodynamic therapy (PDT) is a promising cancer treatment, but its clinical use limited by nontargeted photosensitizers (PS) that accumulate in normal tissues, causing adverse effects, and poor penetration tumor tissues due to the dense extracellular matrix (ECM). Here an innovative approach presented using cell‐derived nanovesicles (CNVs) engineered with chimeric antigen receptor (CAR) hyaluronidase PH20 enhance targeted PDT. The CAR–PH20 CNVs, loaded photosensitizer pheophorbide (PheoA), specifically target HER2‐expressing cells degrade hyaluronic acid microenvironment (TME), improving drug distribution. In vitro vivo experiments demonstrate increased reactive oxygen species (ROS) generation, improved retention, enhanced therapeutic efficacy compared conventional methods. When combined laser irradiation, these CNVs induce significant cell apoptosis inhibit growth mouse models, while minimizing toxicity tissues. This platform offers strategy for targeted, TME‐modulating PDT efficacy, reduced side marking advance nanodrug‐based therapies.

Language: Английский

Citations

0