Fuel-Driven Enzymatic Reaction Networks to Program Autonomous Thiol/Disulfide Redox Systems
Journal of the American Chemical Society,
Год журнала:
2024,
Номер
146(15), С. 10281 - 10285
Опубликована: Апрель 3, 2024
Fuel-driven
dissipative
formation
of
disulfide
bonds
using
competing
oxidative
activation
and
reductive
deactivation
presents
a
possibly
very
versatile
avenue
for
autonomous
materials
design.
However,
this
is
challenging
to
realize
because
the
direct
annihilation
oxidizing
fuel
deactivating
reducing
agent.
We
overcome
challenge
by
introducing
redox-based
enzymatic
reaction
network
(ERN),
enabling
molecularly
dissolved
thiols
in
fully
manner.
Moreover,
ERN
allows
programming
hydrogel
lifetimes
utilizing
thiol-terminated
star
polymers
(sPEG-SH).
The
can
be
customized
operate
with
aliphatic
aromatic
should
thus
broadly
applicable
functional
thiols.
Язык: Английский
Cysteine‐Based Dynamic Self‐Assembly and Their Importance in the Origins of Life
ChemSystemsChem,
Год журнала:
2024,
Номер
6(4)
Опубликована: Апрель 12, 2024
Abstract
The
knowledge
regarding
the
origins
of
life
from
inanimate
materials
is
still
elusive.
It
was
proposed
that
biological
building
blocks
evolved
inorganic
substances
present
in
early
earth
conditions.
However,
process
by
which
chemistry
can
be
converted
into
biology
has
not
yet
been
achieved
laboratory.
artificial
system
out‐of‐equilibrium
state
must
maintain
a
few
critical
features
life,
like
compartmentalization,
metabolism,
and
replication,
to
considered
alive.
In
this
direction,
working
with
cysteine
(Cys)‐based
molecules
strategic
understand
evolution
process.
presence
sulphydryl
(−SH)
group
Cys‐residue
build
dynamic
equilibrium
through
disulfide
redox
under
proper
guidance
oxidizing
reducing
agents.
review
article,
our
primary
focus
discuss
Cys‐containing
short‐peptide‐based
self‐assembly
disassembly
processes.
formation
bonds
sometimes
helps
gelation,
but
reverse
also
true
some
cases.
later
part
we
cover
fact
these
sulphydryl‐based
systems
have
shown
their
adaptability
mimic
different
life‐essential
criteria
participate
Darwinian
evolution.
Язык: Английский
Observing the Dynamics of an Electrochemically Driven Active Material with Liquid Electron Microscopy
ACS Nano,
Год журнала:
2024,
Номер
18(18), С. 11898 - 11909
Опубликована: Апрель 22, 2024
Electrochemical
liquid
electron
microscopy
has
revolutionized
our
understanding
of
nanomaterial
dynamics
by
allowing
for
direct
observation
their
electrochemical
production.
This
technique,
primarily
applied
to
inorganic
materials,
is
now
being
used
explore
the
self-assembly
active
molecular
materials.
Our
study
examines
these
across
various
scales,
from
nanoscale
behavior
individual
fibers
micrometer-scale
hierarchical
evolution
fiber
clusters.
To
isolate
influences
beam
and
electrical
potential
on
material
behavior,
we
conducted
thorough
beam–sample
interaction
analyses.
findings
reveal
that
materials
at
are
shaped
proximity
electrode
current.
By
integrating
observations
with
reaction–diffusion
simulations,
uncover
local
structures
formation
history
play
a
crucial
role
in
determining
assembly
rates.
suggests
emergence
nonequilibrium
can
locally
accelerate
further
structural
development,
offering
insights
into
under
conditions.
Язык: Английский
Design and Fabrication of Viscoelastic Hydrogels as Extracellular Matrix Mimicry for Cell Engineering
Chem & Bio Engineering,
Год журнала:
2024,
Номер
1(11), С. 916 - 933
Опубликована: Окт. 8, 2024
The
extracellular
matrix
(ECM)
performs
both
as
a
static
scaffold
and
dynamic,
viscoelastic
milieu
that
actively
participates
in
cell
signaling
mechanical
feedback
loops.
Recently,
biomaterials
with
tunable
properties
have
been
utilized
to
mimic
the
native
ECM
fields
of
tissue
engineering
regenerative
medicines.
These
materials
can
be
designed
support
attachment,
proliferation,
differentiation,
facilitating
repair
or
replacement
damaged
tissues.
Moreover,
viscoelasticity
modulation
mimicry
helps
develop
therapeutic
strategies
for
diseases
involving
altered
tissues
such
fibrosis
cancer.
study
biomaterial
thus
intersects
broad
spectrum
biological
medical
disciplines,
offering
insights
into
fundamental
biology
practical
solutions
improving
human
health.
This
review
delves
design
fabrication
hydrogels,
focusing
particularly
on
two
major
parameters,
strength
stress
relaxation,
how
hydrogel
mechanics
influence
interactions
between
living
cells
surrounding
microenvironments.
Meanwhile,
this
discusses
current
bottlenecks
hydrogel-cell
studies,
highlighting
challenges
parameter
decoupling,
long-term
stable
maintenance
microenvironment,
general
applicability
testing
standards
conversion
protocols.
Язык: Английский