Asian Journal of Organic Chemistry,
Год журнала:
2024,
Номер
13(11)
Опубликована: Авг. 16, 2024
Abstract
Visible‐light‐driven
dual
catalysis
was
employed
to
stereoselectively
produce
densely
substituted
cyclobutanes
from
Erlenmeyer‐Plöchl
azlactones.
The
single‐step
preparation
of
non‐natural
amino
acid
dimers
containing
the
cyclobutane
moiety
achieved
through
a
synergy
between
iridium
photocatalysis
and
catalytic
nickel(II)
triflate
as
Lewis
acid.
desired
1,2‐(
zeta
)‐
Z
,
E
‐isomers
were
isolated
in
good
yields
with
high
regio‐
diastereoselectivity
(in
all
cases,
>19
:
1
d.r.).
To
best
our
knowledge,
this
is
first
report
direct
access
truxinic
analogues
using
Control
experiments,
EPR
reaction
monitoring,
DFT
calculations
suggest
that
presence
acid,
combined
use
powerful
blue
LEDs,
plays
crucial
role
reactivity
reaction.
ACS Catalysis,
Год журнала:
2024,
Номер
14(11), С. 9055 - 9076
Опубликована: Май 29, 2024
Metallaphotoredox
catalysis
can
unlock
useful
pathways
for
transforming
organic
reactants
into
desirable
products,
largely
due
to
the
conversion
of
photon
energy
chemical
potential
drive
redox
and
bond
transformation
processes.
Despite
importance
these
processes
cross-coupling
reactions
other
transformations,
their
mechanistic
details
are
only
superficially
understood.
In
this
review,
we
have
provided
a
detailed
summary
various
photoredox
mechanisms
that
been
proposed
date
Ni-bipyridine
(bpy)
complexes,
focusing
separately
on
photosensitized
direct
excitation
reaction
By
highlighting
multiple
key
findings,
depict
how
mechanisms,
which
ultimately
define
substrate
scope,
themselves
defined
by
ground-
excited-state
geometric
electronic
structures
Ni-based
intermediates.
We
further
identify
knowledge
gaps
motivate
future
studies
development
synergistic
research
approaches
spanning
physical,
organic,
inorganic
chemistry
communities.
Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
63(24)
Опубликована: Апрель 11, 2024
We
report
a
family
of
donor-acceptor
thermally
activated
delayed
fluorescent
(TADF)
compounds
based
on
derivatives
DMAC-TRZ,
that
are
strongly
photoreducing.
Both
E
Nature Communications,
Год журнала:
2024,
Номер
15(1)
Опубликована: Июль 19, 2024
Abstract
Visible-light
photocatalysis
has
evolved
as
a
powerful
technique
to
enable
controllable
radical
reactions.
Exploring
unique
photocatalytic
mode
for
obtaining
new
chemoselectivity
and
product
diversity
is
of
great
significance.
Herein,
we
present
photo-induced
chemoselective
1,2-diheteroarylation
unactivated
alkenes
utilizing
halopyridines
quinolines.
The
ring-fused
azaarenes
serve
not
only
substrate,
but
also
potential
precursors
halogen-atom
abstraction
pyridyl
generation
in
this
photocatalysis.
As
complement
metal
catalysis,
process
with
mild
redox
neutral
conditions
assembles
two
different
heteroaryl
groups
into
regioselectively
contribute
broad
substrates
scope.
obtained
products
containing
aza-arene
units
permit
various
further
diversifications,
demonstrating
the
synthetic
utility
protocol.
We
anticipate
that
protocol
will
trigger
advancement
alkyl/aryl
halides
activation.
Journal of the American Chemical Society,
Год журнала:
2025,
Номер
147(9), С. 7161 - 7181
Опубликована: Фев. 20, 2025
Photocatalytic
cancer
therapy
(PCT)
has
emerged
as
a
cutting-edge
anticancer
mechanism
of
action,
harnessing
light
energy
to
mediate
the
catalytic
oxidation
intracellular
substrates.
PCT
is
significant
current
importance
due
its
potential
address
limitations
conventional
chemotherapy,
particularly
drug
resistance
and
side
effects.
This
approach
offers
noninvasive,
targeted
treatment
option
by
utilizing
metal-based
photocatalysts
induce
redox
metabolic
disorders
within
cells.
The
disrupt
cell
metabolism
converting
NADH/NAD(P)H
NAD+/NAD(P)+
via
photoredox
processes,
altering
NAD+/NADH
or
NAD(P)+/NAD(P)H
ratios,
which
are
crucial
for
cellular
metabolism.
Ir(III),
Ru(II),
Re(I),
Os(II)
demonstrated
promising
efficacy.
Despite
these
developments,
gaps
remain
in
literature
translating
this
new
into
clinical
trials.
Perspective
critically
examines
developments
research
area
provides
future
directions
designing
efficient
PCT.
Molecules,
Год журнала:
2025,
Номер
30(8), С. 1680 - 1680
Опубликована: Апрель 9, 2025
Photocatalysis
is
a
key
strategy
for
the
development
of
sustainable
solar-driven
chemical
processes.
In
this
work,
we
report
synthesis
and
characterization
novel
organometallo–ionosilica
material
derived
from
self-condensation
an
alcoxysilane
functionalized
Ir(III)
complex.
acetonitrile
suspension,
retains
photophysical
properties
its
precursor
in
solution
same
solvent,
together
with
significant
absorption
visible
between
400
500
nm.
As
heterogeneous
photocatalyst,
showed
high
efficiency
reductive
dehalogenation
2-bromoacetophenone
under
blue
light
irradiation,
achieving
yields
conversion
about
90%,
excellent
recyclability
seven
catalytic
cycles,
retaining
more
than
70%
efficiency.
All
these
self-condensed
highlight
potential
as
efficient
photocatalyst
applications
organic
redox
Epitomised
by
4CzIPN,
donor-acceptor
(D-A)
thermally
activated
delayed
fluorescence
(TADF)
compounds
based
on
the
carbazoyl
dicyanobenzene
have
now
become
widely
used
as
they
are
sustainable
photocatalyst
alternatives
to
organometallic
complexes
owing
their
similar
optoelectronic
properties
many
of
iridium-based
photocatalysts.
Multi-resonant
TADF
(MR-TADF)
offer
distinct
advantages
over
D-A
more
intense
low-energy
absorption
bands,
offering
faster
reaction
kinetics,
and
less
sensitive
polarity
environment,
mitigating
undesired
energy
loss
that
typically
accompanies
CT
excited
states
Here
we
report
assessment
strongly
photoreducing
boron-
nitrogen-doped
MR-TADF
DABNA-1,
tDABNA,
CzBN
DtBuCzB
across
a
range
benchmark
photochemical
reactions.
The
structural
differences
between
each
member
this
library
photocatalysts
enables
modulation
ground-
excited-state
redox
potentials.
These
performed
competitively
compared
literature-known
Ph-PTZ
fac-Ir(ppy)3.
