Journal of Materials Chemistry B, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
This review discusses phototherapeutic nanosystems for oral cancer, emphasizing diverse drug delivery systems, advanced photodynamic therapy approaches, and combination therapies.
Язык: Английский
Pharmacological Research, Год журнала: 2024, Номер 206, С. 107258 - 107258
Опубликована: Июнь 21, 2024
Several cardiovascular illnesses are associated with aberrant activation of cellular pyroptosis, ferroptosis, necroptosis, cuproptosis, disulfidptosis and macrophage polarisation as hallmarks contributing to vascular damage abnormal cardiac function. Meanwhile, these three novel forms dysfunction closely related mitochondrial homeostasis. Mitochondria the main organelles that supply energy maintain Mitochondrial stability is maintained through a series regulatory pathways, such fission, fusion mitophagy. Studies have shown (e.g., impaired dynamics mitophagy) promotes ROS production, leading oxidative stress, which induces M1 phenotypic polarisation. Therefore, an in-depth knowledge dynamic regulation mitochondria during necessary understand disease development. This paper systematically summarises impact changes in mitophagy on regulating dysfunctions promote understanding pathogenesis diseases provide corresponding theoretical references for treating diseases.
Язык: Английский
Процитировано
20
Molecular Cancer, Год журнала: 2025, Номер 24(1)
Опубликована: Янв. 15, 2025
Biometallic ions play a crucial role in regulating the immune system. In recent years, cancer immunotherapy has become breakthrough treatment, achieving good efficacy wide range of cancers with its specificity and durability advantages. However, existing therapies still face challenges, such as tolerance escape. (e.g. zinc, copper, magnesium, manganese, etc.) can assist enhancing through activation cells, enhancement tumor antigen presentation, improvement microenvironment. addition, biometallic derivatives directly inhibit cell progression offer possibility effectively overcoming limitations current by promoting responses reducing immunosuppressive signals. This review explores potential application prospects immunotherapy, providing new ideas for future clinical metal part helping to guide development more effective safe therapeutic regimens.
Язык: Английский
Процитировано
1
Advanced Materials, Год журнала: 2024, Номер unknown
Опубликована: Окт. 29, 2024
Given the crucial role of abnormal homeostasis in tumor cells for maintaining their growth, it may be more efficient with less effort to develop anti-tumor strategies that target multiple combined mechanisms by disrupting intracellular homeostasis. Here, a copper-based nanoinducer (CGBH NNs) enzyme-like activities is designed and constructed induce disulfidptosis-enhanced pyroptosis through effective immunotherapy. Within microenvironment (TME), CGBH NNs can disrupt glucose inhibit NADPH production, leading accumulation cystine, which further blocked substrate key enzyme synthesizing glutathione. Subsequently, cascade catalytic reactions involving (glutathione peroxidase-like, oxidase peroxidase-like activities), produce massive reactive oxygen species (ROS) redox homeostasis, resulting pyroptosis. The undergoing immunogenic release various cytosolic contents inflammatory factors, eliciting robust immune responses facilitating cell infiltration, reprogramming immunosuppressive TME. After combination checkpoint blockade therapy, effectively suppress growth prolong survival time tumor-bearing mice. This work presents novel paradigm trigger destroying
Язык: Английский
Процитировано
6
Science China Chemistry, Год журнала: 2025, Номер unknown
Опубликована: Янв. 2, 2025
Язык: Английский
Процитировано
0
Frontiers in Oncology, Год журнала: 2025, Номер 14
Опубликована: Янв. 9, 2025
Copper, an essential trace element and biochemical cofactor in humans plays a critical role maintaining health. Recent studies have identified significant association between copper levels the progression metastasis of cancer. Copper is primarily absorbed intestinal tract, often leading to imbalance ions body. Colorectal cancer (CRC), most common originating intestines, thrives environment with elevated concentrations. Current research focused on uncovering relationship CRC which has introduced new concepts such as cuproplasia cuproptosis, significantly deepening our understanding copper's influence cell proliferation death. Cuproplasia kind mediated by co-regulatory activities enzymes non-enzymatic factors, while cuproptosis refers death induced excessive copper, results abnormal oligomerization lipacylated proteins reduction iron-sulfur cluster proteins. Exploring opens avenues for treating CRC. This review aims summarize promoting colorectal cancer, dual effects tumor microenvironment (TME), strategies leveraging this unique induce Understanding holds promise establishing theoretical foundation innovative therapeutic
Язык: Английский
Процитировано
0
Free Radical Biology and Medicine, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
International Journal of Nanomedicine, Год журнала: 2025, Номер Volume 20, С. 1509 - 1528
Опубликована: Фев. 1, 2025
Abstract: Macrophage immunotherapy is an emerging therapeutic approach designed for modulating the immune response to alleviate disease symptoms. The balance between pro-inflammatory and anti-inflammatory macrophages plays a pivotal role in progression of inflammatory diseases. Mitochondria, often referred as "power plants" cell, are essential organelles responsible critical functions such energy metabolism, material synthesis, signal transduction. functional state mitochondria closely linked macrophage polarization, prompting interest strategies that target regulate this process. To end, biomaterials with excellent targeting capabilities effective properties have been developed influence mitochondrial function polarization. However, comprehensive summary biomaterial-driven modulation control phenotypes still lacking. This review highlights polarization discusses mediated by biomaterials, including mitochondria-targeted biomaterials. Finally, prospects challenges use these explored, emphasizing their potential be translated clinic. It anticipated will serve valuable resource materials scientists clinicians development next-generation Keywords: macrophages,
Язык: Английский
Процитировано
0
Coordination Chemistry Reviews, Год журнала: 2025, Номер 534, С. 216542 - 216542
Опубликована: Март 13, 2025
Язык: Английский
Процитировано
0
Coordination Chemistry Reviews, Год журнала: 2024, Номер 526, С. 216319 - 216319
Опубликована: Ноя. 28, 2024
Язык: Английский
Процитировано
3
ChemMedChem, Год журнала: 2024, Номер 19(21)
Опубликована: Июнь 29, 2024
Abstract Copper, as an essential trace nutrient for human, plays a crucial role in numerous cellular activities, and is vital maintaining homeostasis organisms. Deviations from normal intracellular copper concentration range can disrupt the lead to cell death. Cell death process which cells lose their vitality cannot sustain metabolism, has various forms. The recently discovered cuproptosis mechanism differs previously recognized forms, triggered by accumulation. discovery of sparked interest among researchers, this been applied treatment intractable diseases, including different types cancer. However, developed cuproptosis‐based therapies have revealed certain limitations, such low immunostimulatory efficiency, poor tumor targeting, inhibition microenvironment. Therefore, researchers are devoted combining with existing cancer develop more effective synergistic therapies. This review summarizes latest research advancements cancer, focus on Finally, it provides outlook future development anti‐tumor therapy.
Язык: Английский
Процитировано
2