Energy Transfer (EnT)-Mediated Stereoselective Aryl-Heterofunctionalization of Unactivated Alkynes via Radical Rearrangement
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 5, 2025
In
this
study,
we
present
a
novel
catalyst-free
energy
transfer
mediated
radical
rearrangement
strategy
for
the
aryl-heterofunctionalization
of
unactivated
alkynes,
leading
to
synthesis
polyfunctional
olefins
with
exceptional
stereoselectivity.
This
innovative
approach,
driven
by
visible
light,
exemplifies
green
chemistry
principles
eliminating
reliance
on
transition
metals,
external
oxidants,
and
photocatalysts.
The
broad
applicability
our
method
is
demonstrated
through
successful
diverse
array
compounds,
including
vinyl
sulfones,
selenides,
sulfides.
Preliminary
mechanistic
insights
suggest
an
mechanism,
highlighting
efficiency
selectivity
strategy.
Язык: Английский
Efficient and regioselective C=S bond difunctionalization through a three-component radical relay strategy
Chinese Chemical Letters,
Год журнала:
2024,
Номер
unknown, С. 110424 - 110424
Опубликована: Сен. 1, 2024
Язык: Английский
Photoinduced Carbamoylarylation of Alkynes with N-Aryl Oxamic Acids
Organic Letters,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 2, 2025
1,2-Difunctionalization
of
alkynes
is
an
attractive
synthetic
protocol,
because
it
can
achieve
a
high
step
economy
and
provide
various
complex
organic
molecules.
This
study
demonstrates
the
visible-light-induced
carbamoylarylation
terminal
using
N-aryl
oxamic
acids
as
bifunctional
reagents.
The
transformation
involves
addition
carbamoyl
radicals
to
alkenes,
resulting
in
1,4-aryl
migration
via
C(aryl)-N
bond
cleavage
afford
corresponding
arylacrylamides
moderate
good
yields.
Язык: Английский