A Novel Machine Learning-enhanced Microfluidic CircRNAs Detection Platform for Breast Cancer Precision Diagnosis DOI
Lei Mou, Xinyu Zhang,

Zixin Lin

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: May 7, 2025

Abstract The discovery and favourable detection of breast cancer biomarkers are significant for diagnosis. Here, we show that hsa_circ_044235 hsa_circ_000250 effective Moreover, present an integrated electrochemical microfluidic circRNAs platform (ECMCDP) combined gold platinum nanoparticles (AuPts)-modified screen-printed electrodes (SPEs), catalytic hairpin assembly (CHA), chip a customed low-power electronic system simultaneous two cancer-associated circRNAs. limit (LOD) were 0.12 fM 0.1 fM, the diagnostic accuracy 92.50% 88.75% in clinical blood samples, respectively. was validated using paired pre-/post-operative tissue samples. Combined with five machine learning-based models, ensemble diagnosis model achieved high 93.75%. This work aims to identify novel establish innovative improve support prognosis assessment.

Language: Английский

Diving into Sweat: Advances, Challenges, and Future Directions in Wearable Sweat Sensing DOI Creative Commons

Andre Childs,

Beatriz Mayol, José A. Lasalde‐Ramírez

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(36), P. 24605 - 24616

Published: Aug. 26, 2024

Sweat analysis has advanced from diagnosing cystic fibrosis and testing for illicit drugs to noninvasive monitoring of health biomarkers. This article introduces the rapid development wearable flexible sweat sensors, highlighting key milestones various sensing strategies real-time analytes. We discuss challenges such as developing high-performance nanomaterial-based biosensors, ensuring continuous production sampling, achieving high sweat/blood correlation, biocompatibility. The potential machine learning enhance these sensors personalized healthcare is presented, enabling tracking prediction physiological changes disease onset. Leveraging advancements in electronics, nanomaterials, biosensing, data analytics, biosensors promise revolutionize management, prevention, prediction, promoting healthier lifestyles transforming medical practices globally.

Language: Английский

Citations

23
Nanotechnology-Based Wearable Electrochemical Biosensor for Disease Diagnosis DOI
Jinho Yoon,

Nayeon Kwon,

Yejin Lee

et al.

ACS Sensors, Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

Recently, flexible electronics have significantly transformed information and communications technology (ICT). In particular, wearable devices, via integration with attachable biosensors, driven the development of new types biosensors diagnostic devices for point-of-care testing (POCT). Moreover, electrochemical can be applied to diagnose diseases in real time based on synergistic effect generated from incorporation technique. Besides, improve sensitivity while retaining their wearability, novel nanomaterials nanotechnologies been introduced. this review, recent studies nanotechnology-based accurate disease diagnosis are discussed. First, widely used techniques developing electrodes, including nanolithography- nano/microneedle-based patches, presented. Next, latest such as diabetes dermatitis discussed by categorizing into categories. Finally, review explores research trends application nanotechnology-enabled nanopatterning nano/microneedle technologies biosensors. This suggests approaches methods real-time under POCT applications.

Language: Английский

Citations

3
DNA Nanomaterial-Based Electrochemical Biosensors for Clinical Diagnosis DOI

Mengge Chu,

Yawen Zhang,

Cailing Ji

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(46), P. 31713 - 31736

Published: Nov. 7, 2024

Sensitive and quantitative detection of chemical biological molecules for screening, diagnosis monitoring diseases is essential to treatment planning response monitoring. Electrochemical biosensors are fast, sensitive, easy miniaturize, which has led rapid development in clinical diagnosis. Benefiting from their excellent molecular recognition ability high programmability, DNA nanomaterials could overcome the Debye length electrochemical by simple design well suited as elements biosensors. Therefore, enhance sensitivity specificity biosensors, significant progress been made recent years optimizing design. Here, establishment sensing strategies based on reviewed detail. First, structural nanomaterial examined improving overcoming length. In addition, electrical signal transduction amplification reviewed, applications nanomaterial-based integrated devices further summarized. Finally, main opportunities challenges detecting disease biomarkers presented an aim guide with specificity.

Language: Английский

Citations

14
Cortisol: Biosensing and detection strategies DOI

Sesuraj Balasamy,

Raji Atchudan, Sandeep Arya

et al.

Clinica Chimica Acta, Journal Year: 2024, Volume and Issue: 562, P. 119888 - 119888

Published: July 24, 2024

Language: Английский

Citations

13
Biosensors in Biomedical Research: Bridging Cell and Tissue Engineering and Real-Time Monitoring DOI
Zahra Rezaei, Niyou Wang, A. Rodríguez

et al.

Current Opinion in Biomedical Engineering, Journal Year: 2025, Volume and Issue: unknown, P. 100582 - 100582

Published: Feb. 1, 2025

Language: Английский

Citations

2
A review on in-plane ordered MXenes-based materials in addressing challenges faced by biosensor applications DOI
Yedluri Anil Kumar, Tholkappiyan Ramachandran, Avijit Ghosh

et al.

Journal of Energy Storage, Journal Year: 2025, Volume and Issue: 121, P. 116507 - 116507

Published: April 8, 2025

Language: Английский

Citations

2
Wearable Electrochemical Biosensors for Advanced Healthcare Monitoring DOI Creative Commons
Haowei Duan, Shuhua Peng, Shuai He

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 12(2)

Published: Nov. 26, 2024

Abstract Recent advancements in wearable electrochemical biosensors have opened new avenues for on‐body and continuous detection of biomarkers, enabling personalized, real‐time, preventive healthcare. While glucose monitoring has set a precedent biosensors, the field is rapidly expanding to include wider range analytes crucial disease diagnosis, treatment, management. In this review, recent key innovations are examined design manufacturing underpinning these biosensing platforms including biorecognition elements, signal transduction methods, electrode substrate materials, fabrication techniques. The applications then highlighted detecting variety biochemical markers, such as small molecules, hormones, drugs, macromolecules, biofluids interstitial fluid, sweat, wound exudate, saliva, tears. Additionally, review also covers advances platforms, multi‐sensory integration, closed‐loop control, power supply. Furthermore, challenges associated with critical issues discussed, biocompatibility, biofouling, sensor degradation, opportunities materials science, nanotechnology, artificial intelligence overcome limitations.

Language: Английский

Citations

9
Engineering 3D Microtip Gates of All-Polymer Organic Electrochemical Transistors for Rapid Femtomolar Nucleic-Acid-Based Saliva Testing DOI

Xingyu Meng,

Zhenkai Yi,

Xuanxuan Liu

et al.

Biosensors and Bioelectronics, Journal Year: 2025, Volume and Issue: 273, P. 117170 - 117170

Published: Jan. 14, 2025

Language: Английский

Citations

1
Sensing the Future with Graphene-based Wearable Sensors: A review DOI Creative Commons
Md. Kamrul Hassan Chowdhury, Habibur Rahman Anik, Mahmuda Akter

et al.

Results in Materials, Journal Year: 2024, Volume and Issue: unknown, P. 100646 - 100646

Published: Dec. 1, 2024

Language: Английский

Citations

4
Laser-engraved graphene on fabrics for customizable and scalable textile electronics DOI Creative Commons

Haoxuan Ma,

Huarun Liang,

Guixian Zhu

et al.

Device, Journal Year: 2024, Volume and Issue: unknown, P. 100573 - 100573

Published: Oct. 1, 2024

Language: Английский

Citations

3