Heliyon, Год журнала: 2024, Номер 11(1), С. e41103 - e41103
Опубликована: Дек. 11, 2024
Язык: Английский
Antibiotics, Год журнала: 2025, Номер 14(2), С. 207 - 207
Опубликована: Фев. 18, 2025
The rapid rise of antibiotic resistance has become a global health crisis, necessitating the development innovative strategies to combat multidrug-resistant (MDR) pathogens. Nanomaterials have emerged as promising tools in this fight, offering unique physicochemical properties that enhance efficacy, overcome mechanisms, and provide alternative therapeutic approaches. This review explores diverse nanomaterial-based used resistance, focusing on their mechanisms action practical applications. such metal nanoparticles, carbon-based nanomaterials, polymeric nanostructures exhibit antibacterial through various pathways, including generation reactive oxygen species (ROS), disruption bacterial membranes, enhancement delivery. Additionally, ability nanomaterials bypass traditional biofilm formation efflux pumps, been demonstrated numerous studies. also discusses synergistic effects observed when are combined with conventional antibiotics, leading increased susceptibility reduced required dosages. By highlighting recent advancements clinical applications nanomaterial-antibiotic combinations, paper provides comprehensive overview how reshaping future therapies. Future research directions challenges, toxicity scalability, addressed guide safer, more effective treatments.
Язык: Английский
Процитировано
2
Plants, Год журнала: 2025, Номер 14(5), С. 716 - 716
Опубликована: Фев. 26, 2025
Nanotechnology has emerged as a transformative field in agriculture, offering innovative solutions to enhance plant growth and resilience against abiotic stresses. This review explores the diverse applications of nanomaterials focusing on their role promoting development improving tolerance drought, salinity, heavy metals, temperature fluctuations. The method classifies commonly employed sciences examines unique physicochemical properties that facilitate interactions with plants. Key mechanisms nanomaterial uptake, transport, influence plants at cellular molecular levels are outlined, emphasizing effects nutrient absorption, photosynthetic efficiency, overall biomass production. basis stress is examined, highlighting nanomaterial-induced regulation reactive oxygen species, antioxidant activity, gene expression, hormonal balance. Furthermore, this addresses environmental health implications nanomaterials, sustainable eco-friendly approaches mitigate potential risks. integration nanotechnology precision agriculture smart technologies promises revolutionize agricultural practices. provides valuable insights into future directions R&D, paving way for more resilient system.
Язык: Английский
Процитировано
2
Marine Drugs, Год журнала: 2024, Номер 22(12), С. 549 - 549
Опубликована: Дек. 4, 2024
The green synthesis of silver (Ag) and zinc oxide (ZnO) nanoparticles (NPs), as well Ag/Ag2O/ZnO nanocomposites (NCs), using polar apolar extracts Chlorella vulgaris, offers a sustainable method for producing nanomaterials with tunable properties. impact the environment nanomaterials’ characteristics on cytotoxicity was evaluated by examining reactive species production their effects mitochondrial bioenergetic functions. Cytotoxicity assays PC12 cells, cell line originated from rat pheochromocytoma, an adrenal medulla tumor, demonstrated that Ag/Ag2O NPs synthesized (Ag/Ag2O A) P) exhibited significant cytotoxic effects, primarily driven Ag+ ion release disruption function. However, it is more likely organic content, rather than size, influenced anticancer activity, commercial Ag NPs, despite smaller crystallite sizes, exhibit less effective activity. ZnO P showed increased oxygen (ROS) generation, correlated higher cytotoxicity, while A produced lower ROS levels, resulting in diminished effects. comparative analysis revealed differences LD50 values toxicity profiles. Differentiated cells resistance to ZnO, AgNPs Ag/Ag2O-based materials had similar both types. This study emphasizes crucial role bioactive compounds C. vulgaris modulating nanoparticle surface chemistry, cytotoxicity. results provide valuable insights designing safer biomedical applications, especially targeting tumor-like exploring relationships between polarity, capping agents, nanocomposite structures.
Язык: Английский
Процитировано
6
Industrial Crops and Products, Год журнала: 2025, Номер 229, С. 121022 - 121022
Опубликована: Апрель 12, 2025
Язык: Английский
Процитировано
0
Redox Biology, Год журнала: 2025, Номер unknown, С. 103630 - 103630
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Applied Materials Today, Год журнала: 2024, Номер 41, С. 102442 - 102442
Опубликована: Сен. 23, 2024
Язык: Английский
Процитировано
4
Physiological and Molecular Plant Pathology, Год журнала: 2025, Номер unknown, С. 102570 - 102570
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Advanced Science, Год журнала: 2025, Номер unknown
Опубликована: Янв. 9, 2025
Abstract Spinal cord injury (SCI) impairs the central nervous system and induces myelin‐sheath‐deterioration because of reactive oxygen species (ROS), further hindering recovery function. Herein, simultaneously emergency treatment dynamic luminescence severity assessment (SETLSA) strategy is designed for SCI based on cerium (Ce)‐doped upconversion antioxidant nanoenzymes (Ce@UCNP‐BCH). Ce@UCNP‐BCH can not only efficiently eliminate localized ROS, but dynamically monitor oxidative state in repair process using a ratiometric signal. Moreover, classic basso mouse scale score immunofluorescence analysis together exhibit that effectively facilitates regeneration spinal including myelin sheath, promotes functional mice. Particularly, study combines snATAC‐eq snRNA‐seq to reveal heterogeneity tissue following treatment. The findings significant increase myelinating oligodendrocytes, as well higher expression myelination‐related genes, also reveals gene regulatory dynamics remyelination after Besides, ETLSA synergistically boosts ROS consumption through superoxide dismutase (SOD)‐related pathways SOD‐siRNA In conclusion, this SETLSA with blocking monitoring stress has enriched toolkit promoting repair.
Язык: Английский
Процитировано
0
Advanced Healthcare Materials, Год журнала: 2025, Номер unknown
Опубликована: Янв. 19, 2025
Abstract Dry eye disease (DED) is a multifaceted ocular surface disorder that significantly impacts patients’ daily lives and imposes substantial economic burden on society. Oxidative stress, induced by the overproduction of reactive oxygen species (ROS), critical factor perpetuating inflammatory cycle in DED. Effectively scavenging ROS essential to impede progression In this study, boronophenylalanine‐ containing polydopamine (PDA‐PBA) nanoparticles are developed loaded with melatonin (MT), which blended poly(vinyl alcohol) (PVA) create drops PVA/ PDA‐PBA@MT (PPP@MT). vitro vivo studies demonstrate PPP@MT exhibits dual functionalities reducing production downregulating pathways, thereby preserving mitochondrial integrity further inhibiting programmed cell death. Following treatment, tear secretion, corneal structure, number goblet cells markedly restored mouse model dry eye, indicating therapeutic efficacy agent. Collectively, PPP@MT, characterized minimal side effects favorable bioavailability, offers promising insights for management DED other ROS‐mediated disorders.
Язык: Английский
Процитировано
0
Physiological and Molecular Plant Pathology, Год журнала: 2025, Номер unknown, С. 102586 - 102586
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0