Antibiotics,
Journal Year:
2025,
Volume and Issue:
14(2), P. 207 - 207
Published: Feb. 18, 2025
The
rapid
rise
of
antibiotic
resistance
has
become
a
global
health
crisis,
necessitating
the
development
innovative
strategies
to
combat
multidrug-resistant
(MDR)
pathogens.
Nanomaterials
have
emerged
as
promising
tools
in
this
fight,
offering
unique
physicochemical
properties
that
enhance
efficacy,
overcome
mechanisms,
and
provide
alternative
therapeutic
approaches.
This
review
explores
diverse
nanomaterial-based
used
resistance,
focusing
on
their
mechanisms
action
practical
applications.
such
metal
nanoparticles,
carbon-based
nanomaterials,
polymeric
nanostructures
exhibit
antibacterial
through
various
pathways,
including
generation
reactive
oxygen
species
(ROS),
disruption
bacterial
membranes,
enhancement
delivery.
Additionally,
ability
nanomaterials
bypass
traditional
biofilm
formation
efflux
pumps,
been
demonstrated
numerous
studies.
also
discusses
synergistic
effects
observed
when
are
combined
with
conventional
antibiotics,
leading
increased
susceptibility
reduced
required
dosages.
By
highlighting
recent
advancements
clinical
applications
nanomaterial-antibiotic
combinations,
paper
provides
comprehensive
overview
how
reshaping
future
therapies.
Future
research
directions
challenges,
toxicity
scalability,
addressed
guide
safer,
more
effective
treatments.
Plants,
Journal Year:
2025,
Volume and Issue:
14(5), P. 716 - 716
Published: Feb. 26, 2025
Nanotechnology
has
emerged
as
a
transformative
field
in
agriculture,
offering
innovative
solutions
to
enhance
plant
growth
and
resilience
against
abiotic
stresses.
This
review
explores
the
diverse
applications
of
nanomaterials
focusing
on
their
role
promoting
development
improving
tolerance
drought,
salinity,
heavy
metals,
temperature
fluctuations.
The
method
classifies
commonly
employed
sciences
examines
unique
physicochemical
properties
that
facilitate
interactions
with
plants.
Key
mechanisms
nanomaterial
uptake,
transport,
influence
plants
at
cellular
molecular
levels
are
outlined,
emphasizing
effects
nutrient
absorption,
photosynthetic
efficiency,
overall
biomass
production.
basis
stress
is
examined,
highlighting
nanomaterial-induced
regulation
reactive
oxygen
species,
antioxidant
activity,
gene
expression,
hormonal
balance.
Furthermore,
this
addresses
environmental
health
implications
nanomaterials,
sustainable
eco-friendly
approaches
mitigate
potential
risks.
integration
nanotechnology
precision
agriculture
smart
technologies
promises
revolutionize
agricultural
practices.
provides
valuable
insights
into
future
directions
R&D,
paving
way
for
more
resilient
system.
Marine Drugs,
Journal Year:
2024,
Volume and Issue:
22(12), P. 549 - 549
Published: Dec. 4, 2024
The
green
synthesis
of
silver
(Ag)
and
zinc
oxide
(ZnO)
nanoparticles
(NPs),
as
well
Ag/Ag2O/ZnO
nanocomposites
(NCs),
using
polar
apolar
extracts
Chlorella
vulgaris,
offers
a
sustainable
method
for
producing
nanomaterials
with
tunable
properties.
impact
the
environment
nanomaterials’
characteristics
on
cytotoxicity
was
evaluated
by
examining
reactive
species
production
their
effects
mitochondrial
bioenergetic
functions.
Cytotoxicity
assays
PC12
cells,
cell
line
originated
from
rat
pheochromocytoma,
an
adrenal
medulla
tumor,
demonstrated
that
Ag/Ag2O
NPs
synthesized
(Ag/Ag2O
A)
P)
exhibited
significant
cytotoxic
effects,
primarily
driven
Ag+
ion
release
disruption
function.
However,
it
is
more
likely
organic
content,
rather
than
size,
influenced
anticancer
activity,
commercial
Ag
NPs,
despite
smaller
crystallite
sizes,
exhibit
less
effective
activity.
ZnO
P
showed
increased
oxygen
(ROS)
generation,
correlated
higher
cytotoxicity,
while
A
produced
lower
ROS
levels,
resulting
in
diminished
effects.
comparative
analysis
revealed
differences
LD50
values
toxicity
profiles.
Differentiated
cells
resistance
to
ZnO,
AgNPs
Ag/Ag2O-based
materials
had
similar
both
types.
This
study
emphasizes
crucial
role
bioactive
compounds
C.
vulgaris
modulating
nanoparticle
surface
chemistry,
cytotoxicity.
results
provide
valuable
insights
designing
safer
biomedical
applications,
especially
targeting
tumor-like
exploring
relationships
between
polarity,
capping
agents,
nanocomposite
structures.
Advanced Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 9, 2025
Abstract
Spinal
cord
injury
(SCI)
impairs
the
central
nervous
system
and
induces
myelin‐sheath‐deterioration
because
of
reactive
oxygen
species
(ROS),
further
hindering
recovery
function.
Herein,
simultaneously
emergency
treatment
dynamic
luminescence
severity
assessment
(SETLSA)
strategy
is
designed
for
SCI
based
on
cerium
(Ce)‐doped
upconversion
antioxidant
nanoenzymes
(Ce@UCNP‐BCH).
Ce@UCNP‐BCH
can
not
only
efficiently
eliminate
localized
ROS,
but
dynamically
monitor
oxidative
state
in
repair
process
using
a
ratiometric
signal.
Moreover,
classic
basso
mouse
scale
score
immunofluorescence
analysis
together
exhibit
that
effectively
facilitates
regeneration
spinal
including
myelin
sheath,
promotes
functional
mice.
Particularly,
study
combines
snATAC‐eq
snRNA‐seq
to
reveal
heterogeneity
tissue
following
treatment.
The
findings
significant
increase
myelinating
oligodendrocytes,
as
well
higher
expression
myelination‐related
genes,
also
reveals
gene
regulatory
dynamics
remyelination
after
Besides,
ETLSA
synergistically
boosts
ROS
consumption
through
superoxide
dismutase
(SOD)‐related
pathways
SOD‐siRNA
In
conclusion,
this
SETLSA
with
blocking
monitoring
stress
has
enriched
toolkit
promoting
repair.
Advanced Healthcare Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 19, 2025
Abstract
Dry
eye
disease
(DED)
is
a
multifaceted
ocular
surface
disorder
that
significantly
impacts
patients’
daily
lives
and
imposes
substantial
economic
burden
on
society.
Oxidative
stress,
induced
by
the
overproduction
of
reactive
oxygen
species
(ROS),
critical
factor
perpetuating
inflammatory
cycle
in
DED.
Effectively
scavenging
ROS
essential
to
impede
progression
In
this
study,
boronophenylalanine‐
containing
polydopamine
(PDA‐PBA)
nanoparticles
are
developed
loaded
with
melatonin
(MT),
which
blended
poly(vinyl
alcohol)
(PVA)
create
drops
PVA/
PDA‐PBA@MT
(PPP@MT).
vitro
vivo
studies
demonstrate
PPP@MT
exhibits
dual
functionalities
reducing
production
downregulating
pathways,
thereby
preserving
mitochondrial
integrity
further
inhibiting
programmed
cell
death.
Following
treatment,
tear
secretion,
corneal
structure,
number
goblet
cells
markedly
restored
mouse
model
dry
eye,
indicating
therapeutic
efficacy
agent.
Collectively,
PPP@MT,
characterized
minimal
side
effects
favorable
bioavailability,
offers
promising
insights
for
management
DED
other
ROS‐mediated
disorders.
Journal of Materials Chemistry B,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
Vanadium
is
a
bioactive
trace
element
with
variable
valence.
Its
pentavalent
form
has
been
confirmed
to
be
capable
of
predominantly
regulating
the
early
and
mid-stage
osteogenic
differentiation
bone
marrow
mesenchymal
stem
cells
(BMSCs)
without
tumor
inhibition,
while
its
tetravalent
exhibits
inhibition
but
only
primarily
modulates
late
angiogenesis.
In
this
study,
multifunctional
tissue
scaffold
consisting
mixed-valence
vanadium-doped
mesoporous
glass
poly(lactic-co-glycolic
acid)
(V(IV/V)-MBG/PLGA)
was
developed
simultaneously
inhibit
recurrence
osteosarcoma
promote
regeneration
operative
defects.
The
in
vitro
results
showed
that
V(IV)
V(V)
species
could
sustainably
released
from
V(IV/V)-MBG
complementarily
enhance
proliferation,
differentiation,
mineralization
BMSCs
by
activating
multiple
signaling
pathways
throughout
whole
osteogenesis
process.
More
importantly,
co-existence
mixed-valent
vanadium
able
continuously
stimulate
generation
excessive
ROS
depletion
GSH
synergistically
supplying
an
appropriate
ratio
thermodynamically
kinetically
maintain
stable
self-circulation
valence
state
alteration,
thus
inducing
UMR-106
cell
death.
rat
model,
V(IV/V)-MBG/PLGA
scaffolds
effectively
suppressed
invasion
promoted
regeneration.
These
suggest
are
promising
strategy
for
treating
tumor-associated
defects,
offering
dual
