Visible-Light-Induced Synergistic W/Cr Catalyzed gem-Difluoroallylation of Unactivated Alkanes

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Фев. 19, 2025

Currently, the scope of Nozaki-Hiyama-Kishi (NHK) reaction is limited to aldehydes and ketones construct alcohol derivatives. Herein, we have described a visible-light-induced synergistic W/Cr(III)-catalyzed NHK-type gem-difluoroallylation unactivated cyclic linear alkanes. The merits feedstock materials, mild conditions, wide functionality tolerance. Mechanistic studies imply favorable reduction CrCl3 CrCl2 by reduced decatungstate W10O325-, thus closing catalytic cycle.

Язык: Английский

Modular reductive radical-polar crossover-based acyl migration reactions of N-vinylimides with alkyl, silyl, and acyl radicals

RSC Advances, Год журнала: 2025, Номер 15(15), С. 11582 - 11586

Опубликована: Янв. 1, 2025

Generation of α-amino ketones: photocatalytic radical addition/acyl migration cascade processes were reported on reactions enamides with dihydroquinazolinones or acyl oxime acetates.

Язык: Английский

Transition-Metal-Free Late-Stage Decarboxylative gem-Difluoroallylation of Primary Alkyl Acids

The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(20), С. 15234 - 15247

Опубликована: Окт. 8, 2024

A transition-metal-free late-stage decarboxylative gem-difluoroallylation of carboxylic acids with α-trifluoromethyl alkenes has been described by the use organo-photoredox catalysis. Both primary alkyl and heteroaryl were readily incorporated. This approach merits feedstock materials, mild reaction conditions, wide functionality tolerance. The synthetic utility this highlighted functionalization a variety acid-containing natural products drug molecules.

Язык: Английский