Transition-Metal-Free Late-Stage Decarboxylative gem-Difluoroallylation of Primary Alkyl Acids DOI

Xian Wei,

Yue Zhang,

Ruofan Lin

et al.

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(20), P. 15234 - 15247

Published: Oct. 8, 2024

A transition-metal-free late-stage decarboxylative gem-difluoroallylation of carboxylic acids with α-trifluoromethyl alkenes has been described by the use organo-photoredox catalysis. Both primary alkyl and heteroaryl were readily incorporated. This approach merits feedstock materials, mild reaction conditions, wide functionality tolerance. The synthetic utility this highlighted functionalization a variety acid-containing natural products drug molecules.

Language: Английский

Visible-Light-Induced Synergistic W/Cr Catalyzed gem-Difluoroallylation of Unactivated Alkanes DOI
Zhijie Zhang, Yue Zhang,

Xinyu Xie

et al.

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 19, 2025

Currently, the scope of Nozaki-Hiyama-Kishi (NHK) reaction is limited to aldehydes and ketones construct alcohol derivatives. Herein, we have described a visible-light-induced synergistic W/Cr(III)-catalyzed NHK-type gem-difluoroallylation unactivated cyclic linear alkanes. The merits feedstock materials, mild conditions, wide functionality tolerance. Mechanistic studies imply favorable reduction CrCl3 CrCl2 by reduced decatungstate W10O325-, thus closing catalytic cycle.

Language: Английский

Citations

0
Modular reductive radical-polar crossover-based acyl migration reactions of N-vinylimides with alkyl, silyl, and acyl radicals DOI Creative Commons

Yutao Jing,

Li Zhang,

Li Qiu

et al.

RSC Advances, Journal Year: 2025, Volume and Issue: 15(15), P. 11582 - 11586

Published: Jan. 1, 2025

Generation of α-amino ketones: photocatalytic radical addition/acyl migration cascade processes were reported on reactions enamides with dihydroquinazolinones or acyl oxime acetates.

Language: Английский

Citations

0
Transition-Metal-Free Late-Stage Decarboxylative gem-Difluoroallylation of Primary Alkyl Acids DOI

Xian Wei,

Yue Zhang,

Ruofan Lin

et al.

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(20), P. 15234 - 15247

Published: Oct. 8, 2024

A transition-metal-free late-stage decarboxylative gem-difluoroallylation of carboxylic acids with α-trifluoromethyl alkenes has been described by the use organo-photoredox catalysis. Both primary alkyl and heteroaryl were readily incorporated. This approach merits feedstock materials, mild reaction conditions, wide functionality tolerance. The synthetic utility this highlighted functionalization a variety acid-containing natural products drug molecules.

Language: Английский

Citations

2