Microfluidic-assisted Biomineralization of Calcium Phosphate: Enhancing Particle Design for Medical and Therapeutic Applications DOI Creative Commons

Carol Yazbleydy Cárdenas Rodriguez,

Nutan Shukla,

Elizaveta Mukhanova

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Ноя. 21, 2024

Abstract Calcium phosphate (CaP) polymorphs are non-toxic and biocompatible, making them intriguing for a variety of applications, including hard tissue regeneration, medicine delivery, vaccine development. Investigating the mechanism calcium nucleation development is critical understanding disorders caused by pathological mineralization developing biomimetic materials with suitable properties. The current CaP in situ/batch biomineralization process follows crystal-formation route pre-nucleation cluster aggregation particles larger than 500 microns. However, due to their large size, synthesis methods may have limited efficiency, scalability, particle uniformity. new technologies producing nano- microparticles biomedicine interesting various reasons. In this context, microfluidic-based technology developed, distinct microfluidic parameters altered, chip architecture allows fine manipulation reaction parameters. obtained conditions yielded 20-100-micron crystal. Furthermore, approach enables straightforward encapsulation two different model dyes: methylene blue (MB) rose Bengal (RB). proposed microfluidic-aided technique provides viable future study production delivery systems.

Язык: Английский

Biomimicry at the nanoscale - a review of nanomaterials inspired by nature DOI Creative Commons
Deepa Mundekkad,

Anjali R Mallya

Nano Trends, Год журнала: 2025, Номер unknown, С. 100119 - 100119

Опубликована: Май 1, 2025

Язык: Английский

Процитировано

0
Cell membrane derived biomimetic nanomedicine for precision delivery of traditional Chinese medicine in cancer therapy DOI

Hang Xiao,

Faisal Raza, Kunwei Li

и другие.

Journal of Controlled Release, Год журнала: 2025, Номер unknown, С. 113829 - 113829

Опубликована: Май 1, 2025

Язык: Английский

Процитировано

0
Engineering Strategies of Plant-Derived Exosome-Like Nanovesicles: Current Knowledge and Future Perspectives DOI Creative Commons
Yuhan Li, Yulong Wang,

Hongrui Zhao

и другие.

International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 12793 - 12815

Опубликована: Ноя. 1, 2024

Plant-derived exosome-like nanovesicles (PELNs) from edible plants, isolated by ultracentrifugation, size exclusion chromatography or other methods, were proved to contain a variety of biologically active and therapeutically specific components. Recently, investigations in the field PELN-based biomedicine have been conducted, which positioned those as promising tools for prevention treatment several diseases, with their natural origin potentially offering superior biocompatibility bioavailability. However, inadequate targeting limited therapeutic effects constrain utility clinical translation PELNs. Thus, strategies aiming at bridging gap engineering PELNs great interest. Those approaches include membrane hybridization, physical chemical surface functionalization encapsulation payloads. Herein, we provide comprehensive overview biogenesis composition, isolation purification methods characterization PELNs, well functions. Current knowledge on construction biomedical application engineered reviewed. Additionally, future directions perspectives this discussed order further enrich expand prospects

Язык: Английский

Процитировано

2
Fabrication of Biomimetic Hybrid Liposomes via Microfluidic Technology: Homotypic Targeting and Antitumor Efficacy Studies in Glioma Cells DOI Creative Commons
Ilaria Arduino, R. Fonte, Federica Sommonte

и другие.

International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 13217 - 13233

Опубликована: Дек. 1, 2024

The treatment of glioblastoma is hindered by the blood-brain barrier (BBB) and rapid drug clearance immune system. To address these challenges, we propose a novel delivery system using liposomes modified with cell membrane fragments. These can evade system, cross BBB, accumulate in tumor tissue through homotypic targeting, thereby delivering drugs like paclitaxel carboplatin more effectively.

Язык: Английский

Процитировано

1
Microfluidic-assisted Biomineralization of Calcium Phosphate: Enhancing Particle Design for Medical and Therapeutic Applications DOI Creative Commons

Carol Yazbleydy Cárdenas Rodriguez,

Nutan Shukla,

Elizaveta Mukhanova

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Ноя. 21, 2024

Abstract Calcium phosphate (CaP) polymorphs are non-toxic and biocompatible, making them intriguing for a variety of applications, including hard tissue regeneration, medicine delivery, vaccine development. Investigating the mechanism calcium nucleation development is critical understanding disorders caused by pathological mineralization developing biomimetic materials with suitable properties. The current CaP in situ/batch biomineralization process follows crystal-formation route pre-nucleation cluster aggregation particles larger than 500 microns. However, due to their large size, synthesis methods may have limited efficiency, scalability, particle uniformity. new technologies producing nano- microparticles biomedicine interesting various reasons. In this context, microfluidic-based technology developed, distinct microfluidic parameters altered, chip architecture allows fine manipulation reaction parameters. obtained conditions yielded 20-100-micron crystal. Furthermore, approach enables straightforward encapsulation two different model dyes: methylene blue (MB) rose Bengal (RB). proposed microfluidic-aided technique provides viable future study production delivery systems.

Язык: Английский

Процитировано

0