Microfluidic-assisted Biomineralization of Calcium Phosphate: Enhancing Particle Design for Medical and Therapeutic Applications DOI Creative Commons

Carol Yazbleydy Cárdenas Rodriguez,

Nutan Shukla,

Elizaveta Mukhanova

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 21, 2024

Abstract Calcium phosphate (CaP) polymorphs are non-toxic and biocompatible, making them intriguing for a variety of applications, including hard tissue regeneration, medicine delivery, vaccine development. Investigating the mechanism calcium nucleation development is critical understanding disorders caused by pathological mineralization developing biomimetic materials with suitable properties. The current CaP in situ/batch biomineralization process follows crystal-formation route pre-nucleation cluster aggregation particles larger than 500 microns. However, due to their large size, synthesis methods may have limited efficiency, scalability, particle uniformity. new technologies producing nano- microparticles biomedicine interesting various reasons. In this context, microfluidic-based technology developed, distinct microfluidic parameters altered, chip architecture allows fine manipulation reaction parameters. obtained conditions yielded 20-100-micron crystal. Furthermore, approach enables straightforward encapsulation two different model dyes: methylene blue (MB) rose Bengal (RB). proposed microfluidic-aided technique provides viable future study production delivery systems.

Language: Английский

Biomimicry at the nanoscale - a review of nanomaterials inspired by nature DOI Creative Commons
Deepa Mundekkad,

Anjali R Mallya

Nano Trends, Journal Year: 2025, Volume and Issue: unknown, P. 100119 - 100119

Published: May 1, 2025

Language: Английский

Citations

0
Cell membrane derived biomimetic nanomedicine for precision delivery of traditional Chinese medicine in cancer therapy DOI

Hang Xiao,

Faisal Raza, Kunwei Li

et al.

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: unknown, P. 113829 - 113829

Published: May 1, 2025

Language: Английский

Citations

0
Engineering Strategies of Plant-Derived Exosome-Like Nanovesicles: Current Knowledge and Future Perspectives DOI Creative Commons
Yuhan Li, Yulong Wang,

Hongrui Zhao

et al.

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 12793 - 12815

Published: Nov. 1, 2024

Plant-derived exosome-like nanovesicles (PELNs) from edible plants, isolated by ultracentrifugation, size exclusion chromatography or other methods, were proved to contain a variety of biologically active and therapeutically specific components. Recently, investigations in the field PELN-based biomedicine have been conducted, which positioned those as promising tools for prevention treatment several diseases, with their natural origin potentially offering superior biocompatibility bioavailability. However, inadequate targeting limited therapeutic effects constrain utility clinical translation PELNs. Thus, strategies aiming at bridging gap engineering PELNs great interest. Those approaches include membrane hybridization, physical chemical surface functionalization encapsulation payloads. Herein, we provide comprehensive overview biogenesis composition, isolation purification methods characterization PELNs, well functions. Current knowledge on construction biomedical application engineered reviewed. Additionally, future directions perspectives this discussed order further enrich expand prospects

Language: Английский

Citations

2
Fabrication of Biomimetic Hybrid Liposomes via Microfluidic Technology: Homotypic Targeting and Antitumor Efficacy Studies in Glioma Cells DOI Creative Commons
Ilaria Arduino, R. Fonte, Federica Sommonte

et al.

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 13217 - 13233

Published: Dec. 1, 2024

The treatment of glioblastoma is hindered by the blood-brain barrier (BBB) and rapid drug clearance immune system. To address these challenges, we propose a novel delivery system using liposomes modified with cell membrane fragments. These can evade system, cross BBB, accumulate in tumor tissue through homotypic targeting, thereby delivering drugs like paclitaxel carboplatin more effectively.

Language: Английский

Citations

0
Microfluidic-assisted Biomineralization of Calcium Phosphate: Enhancing Particle Design for Medical and Therapeutic Applications DOI Creative Commons

Carol Yazbleydy Cárdenas Rodriguez,

Nutan Shukla,

Elizaveta Mukhanova

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 21, 2024

Abstract Calcium phosphate (CaP) polymorphs are non-toxic and biocompatible, making them intriguing for a variety of applications, including hard tissue regeneration, medicine delivery, vaccine development. Investigating the mechanism calcium nucleation development is critical understanding disorders caused by pathological mineralization developing biomimetic materials with suitable properties. The current CaP in situ/batch biomineralization process follows crystal-formation route pre-nucleation cluster aggregation particles larger than 500 microns. However, due to their large size, synthesis methods may have limited efficiency, scalability, particle uniformity. new technologies producing nano- microparticles biomedicine interesting various reasons. In this context, microfluidic-based technology developed, distinct microfluidic parameters altered, chip architecture allows fine manipulation reaction parameters. obtained conditions yielded 20-100-micron crystal. Furthermore, approach enables straightforward encapsulation two different model dyes: methylene blue (MB) rose Bengal (RB). proposed microfluidic-aided technique provides viable future study production delivery systems.

Language: Английский

Citations

0