Cell Biochemistry and Function,
Год журнала:
2024,
Номер
42(8)
Опубликована: Окт. 25, 2024
ABSTRACT
The
endothelial
semipermeable
monolayers
ensure
tissue
homeostasis,
are
subjected
to
a
plethora
of
stimuli,
and
their
function
depends
on
cytoskeletal
integrity
remodeling.
permeability
those
membranes
can
fluctuate
maintain
organ
homeostasis.
In
cases
severe
injury,
inflammation
or
disease,
barrier
hyperpermeability
cause
irreparable
damage
endothelium‐dependent
issues,
eventually
death.
Elucidation
the
signaling
regulating
structure
promotes
development
targeted
pharmacotherapies
towards
disorders
related
impaired
endothelium
(e.g.,
acute
respiratory
distress
syndrome,
sepsis).
Recent
reports
investigate
role
unfolded
protein
response
in
function.
Herein
we
review
components,
function;
interrelations
health
disorder.
Moreover,
emphasize
modulators,
since
they
ameliorate
illness
leak.
International Journal of Pharmaceutics,
Год журнала:
2025,
Номер
670, С. 125186 - 125186
Опубликована: Янв. 8, 2025
The
blood-brain
barrier
(BBB)
plays
a
vital
role
in
protecting
the
central
nervous
system
(CNS)
by
preventing
entry
of
harmful
pathogens
from
bloodstream.
However,
this
also
presents
significant
obstacle
when
it
comes
to
delivering
drugs
for
treatment
neurodegenerative
diseases
and
brain
cancer.
Recent
breakthroughs
nanotechnology
have
paved
way
creation
wide
range
nanoparticles
(NPs)
that
can
serve
as
carriers
diagnosis
therapy.
Regarding
their
promising
properties,
organic
NPs
potential
be
used
effective
drug
delivery
across
BBB
based
on
recent
advancements.
These
remarkable
ability
penetrate
using
various
mechanisms.
This
review
offers
comprehensive
examination
intricate
structure
distinct
properties
BBB,
emphasizing
its
crucial
function
preserving
balance
regulating
transport
ions
molecules.
disruption
conditions
such
stroke,
Alzheimer's
disease,
Parkinson's
disease
highlights
importance
developing
creative
approaches
drugs.
Through
encapsulation
therapeutic
molecules
precise
targeting
processes
vasculature,
NP
formulations
present
hopeful
strategy
improve
BBB.
We
explore
changes
pathological
investigate
factors
affect
successful
into
brain.
In
addition,
we
most
systems
associated
with
shown
positive
results
treating
ischemic
disorders.
opens
up
new
possibilities
nanotechnology-based
therapies
cerebral
diseases.
The Journal of Physiology,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 2, 2025
Abstract
Autism
spectrum
disorder
(ASD)
is
a
prevalent
neurodevelopmental
condition
affecting
substantial
number
of
children
globally,
characterized
by
diverse
aetiologies,
including
genetic
and
environmental
factors.
Emerging
research
suggests
that
neurovascular
dysregulation
during
development
could
significantly
contribute
to
autism.
This
review
synthesizes
the
potential
role
vascular
abnormalities
in
pathogenesis
ASD
explores
insights
from
studies
on
valproic
acid
(VPA)
exposure
neural
tube
development.
VPA,
widely
used
antiepileptic
drug
mood
stabilizer,
crosses
placental
barrier
impacts
developing
fetal
brain.
Studies
indicate
VPA
disrupts
normal
angiogenesis
reducing
expression
levels
endothelial
growth
factor
A
(VEGFA)
its
receptors,
purinergic
signalling,
which
are
crucial
for
both
Such
disruptions
may
lead
neuronal
migration
pathfinding,
potentially
contributing
behavioural
manifestations
ASD.
Thus
despite
relatively
limited
findings,
improper
vascularization
appears
be
ASD,
as
also
suggested
studies.
Integrating
these
insights,
it
hypothesized
factors
should
considered
aetiological
analysis
idiopathic
image
Bioactive Materials,
Год журнала:
2024,
Номер
38, С. 45 - 54
Опубликована: Апрель 23, 2024
Effective
treatment
of
Parkinson's
disease
(PD),
a
prevalent
central
neurodegenerative
disorder
particularly
affecting
the
elderly
population,
still
remains
huge
challenge.
We
present
here
novel
nanomedicine
formulation
based
on
bioactive
hydroxyl-terminated
phosphorous
dendrimers
(termed
as
AK123)
complexed
with
fibronectin
(FN)
anti-inflammatory
and
antioxidative
activities.
The
created
optimized
AK123/FN
nanocomplexes
(NCs)
size
223
nm
display
good
colloidal
stability
in
aqueous
solution
can
be
specifically
taken
up
by
microglia
through
FN-mediated
targeting.
show
that
NCs
are
able
to
consume
excessive
reactive
oxygen
species,
promote
M2
polarization
inhibit
nuclear
factor-kappa
B
signaling
pathway
downregulate
inflammatory
factors.
With
abundant
dendrimer
surface
hydroxyl
terminal
groups,
developed
cross
blood-brain
barrier
(BBB)
exert
targeted
therapy
PD
mouse
model
AK123-mediated
anti-inflammation
for
antioxidant
effects,
thus
reducing
aggregation
α-synuclein
restoring
contents
dopamine
tyrosine
hydroxylase
normal
levels
vivo.
dendrimer/FN
combine
advantages
BBB-crossing
per
se
phosphorus
FN,
which
is
expected
extended
different
diseases.
Journal of Medical Virology,
Год журнала:
2024,
Номер
96(5)
Опубликована: Май 1, 2024
Abstract
The
coronavirus
disease
of
2019
(COVID‐19)
pandemic
has
led
to
more
than
700
million
confirmed
cases
and
nearly
7
deaths.
Although
severe
acute
respiratory
syndrome
coronavirus‐2
(SARS‐CoV‐2)
virus
mainly
infects
the
system,
neurological
complications
are
widely
reported
in
both
infection
long‐COVID
cases.
Despite
success
vaccines
antiviral
treatments,
neuroinvasiveness
SARS‐CoV‐2
remains
an
important
question,
which
is
also
centered
on
mystery
whether
capable
breaching
barriers
into
central
nervous
system.
By
studying
K18‐hACE2
model,
we
observed
clear
evidence
microvascular
damage
breakdown
blood‐brain
barrier
(BBB).
Mechanistically,
caused
pericyte
damage,
tight
junction
loss,
endothelial
activation
vascular
inflammation,
together
drive
injury
BBB
impairment.
In
addition,
blood‐cerebrospinal
fluid
at
choroid
plexus
was
impaired
after
infection.
Therefore,
cerebrovascular
dysfunctions
aspects
COVID‐19
may
contribute
acutely
long
COVID.
Expert Opinion on Drug Delivery,
Год журнала:
2024,
Номер
21(1), С. 91 - 110
Опубликована: Янв. 2, 2024
Using
engineered
exosomes
produced
from
stem
cells
is
an
experimental
therapeutic
approach
for
treating
brain
diseases.
According
to
reports,
preclinical
research
has
demonstrated
notable
neurogenesis
and
angiogenesis
effects
using
modified
cell-derived
exosomes.
These
biological
nanoparticles
have
a
variety
of
anti-apoptotic,
anti-inflammatory,
antioxidant
properties
that
make
them
very
promising
nervous
system
disorders.
