Updates on renal phosphate transport DOI
Carsten A. Wagner, Daniela Egli-Spichtig, Isabel Rubio‐Aliaga

и другие.

Current Opinion in Nephrology & Hypertension, Год журнала: 2025, Номер unknown

Опубликована: Май 13, 2025

Purpose of review The kidneys control systemic phosphate balance by regulating transporters mediating the reabsorption inorganic (Pi). At least three different Na + -driven Pi cotransporters are located in brush border membrane (BBM) proximal tubule cells, NaPi-IIa (SLC34A1), NaPi-IIc (SLC34A3) and PiT-2 (SLC20A2). This will discuss novel aspects their regulation, pharmacology, genetics. Recent findings Renal NaPi not only acutely regulated phosphaturic hormones parathyroid hormone (PTH) Fibroblast Growth Factor 23 (FGF23) but possibly also further mechanisms. A role inositol hexakisphosphate (IP6) kinases has been found deletion from causes hypophosphatemia, hyperphosphaturia, bone demineralization. Inhibitors NaPis elicit phosphaturia may reduce levels PTH FGF23 chronic kidney disease (CKD) models. relevance renal is highlighted loss-of-function mutations SLC34 analysis patients provides new insights into diseases caused variants. Major manifestations include nephrocalcinosis -lithiasis, rickets, variants predispose to an accelerated decline function. Summary regulated, provide drug targets for prevention or treatment hyperphosphatemia, contribute genetic risk develop stones CKD.

Язык: Английский

The basics of phosphate metabolism DOI Creative Commons
Carsten A. Wagner

Nephrology Dialysis Transplantation, Год журнала: 2023, Номер 39(2), С. 190 - 201

Опубликована: Сен. 2, 2023

Phosphorus is an essential mineral that is, in the form of inorganic phosphate (Pi), required for building cell membranes, DNA and RNA molecules, energy metabolism, signal transduction pH buffering. In bone, Pi bone stability apatite. Intestinal absorption dietary depends on its bioavailability has two distinct modes active transcellular passive paracellular absorption. Active transport transporter mediated partly regulated, while mostly bioavailability. Renal excretion controls systemic levels, transporters proximal tubule highly regulated. Deposition release into from soft tissues to be tightly controlled. The endocrine network coordinating intestinal absorption, renal turnover integrates intake metabolic requirements with critical cardiovascular health during states hypophosphataemia or hyperphosphataemia as evident inborn acquired diseases. This review provides integrated overview biology mammals.

Язык: Английский

Процитировано

42
Homeostatic coordination of cellular phosphate uptake and efflux requires an organelle-based receptor for the inositol pyrophosphate IP8 DOI Creative Commons
Xingyao Li,

Regan B Kirkpatrick,

Xiaodong Wang

и другие.

Cell Reports, Год журнала: 2024, Номер 43(6), С. 114316 - 114316

Опубликована: Июнь 1, 2024

Язык: Английский

Процитировано

11
Physiological Concentrations of Calciprotein Particles Trigger Activation and Pro-Inflammatory Response in Endothelial Cells and Monocytes DOI
Д. К. Шишкова, Victoria Markova,

Yulia Markova

и другие.

Biochemistry (Moscow), Год журнала: 2025, Номер 90(1), С. 132 - 160

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

2
Change trends in serum phosphate levels predict in-hospital mortality in critically ill septic patients DOI Creative Commons
Jun Wang, Xiaohua Song,

Shi-Yang Shi

и другие.

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Фев. 25, 2025

Serum phosphate levels are strongly correlated with the prognosis of septic patients. However, previous studies have concentrated on individual levels, and relationship between change trends in serum in-hospital mortality has seldom been reported. We aimed to investigate whether level were associated mortality. classified patients using k-means clustering analysis into clusters changes used logistic regressions explore relationships different mortality, taking cluster smallest as a reference. Restricted cubic spline regression was examine shape correlation Subgroup analyses interaction performed discover potential impact factors. A total 1810 (21.1%) 8586 participants died during their hospital stay. After adjustment for baseline variables, 2 (OR 1.303, 95% CI 1.101–1.542, p = 0.002), 3 1.348, 1.158–1.57, < 0.001), 4 1.652, 1.225–2.222, 0.001) 5 2.745, 2.212–3.407, remained significantly increased The linear according restricted regression. According subgroup analyses, ORs female mechanical ventilation lower than those counterparts across all clusters. Multiplicative additive interactions detected ventilation. First, high unstable is Second, elevated treatments may reduce Third, an increasing trend be more important predicting poor

Язык: Английский

Процитировано

1
U-shaped relationship between serum phosphate levels and mortality in critically ill patients with atrial fibrillation: Insights from the MIMIC-IV database DOI
Yinying He, Jiamei Huang,

Senlin Huang

и другие.

International Journal of Cardiology, Год журнала: 2025, Номер unknown, С. 133283 - 133283

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

1
Mechanistic insights into CKD-MBD-related vascular calcification and its clinical implications DOI
Rupinder Kaur, Ravinder Singh

Life Sciences, Год журнала: 2022, Номер 311, С. 121148 - 121148

Опубликована: Ноя. 3, 2022

Язык: Английский

Процитировано

33
Effects of micronutrients and macronutrients on risk of allergic disease in the European population: a Mendelian randomization study DOI Creative Commons

Xiangyue Zeng,

Zhimin Wu,

Yipeng Pan

и другие.

Food and Agricultural Immunology, Год журнала: 2024, Номер 35(1)

Опубликована: Дек. 19, 2024

Background: Regional lifestyles influence allergic disease risks, with dietary factors being crucial. However, observational studies on micro- and macronutrient impacts are inconsistent.

Язык: Английский

Процитировано

8
Sphingosine kinase 1 inhibition aggravates vascular smooth muscle cell calcification DOI Creative Commons
Mehdi Razazian,

Sheyda Bahiraii,

Isratul Jannat

и другие.

Pflügers Archiv - European Journal of Physiology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 3, 2025

Medial vascular calcification is common in chronic kidney disease patients and linked to hyperphosphatemia. Upon phosphate exposure, intricate signaling events orchestrate pro-calcific effects the vasculature mediated by smooth muscle cells (VSMCs). Sphingosine kinase 1 (SPHK1) produces sphingosine-1-phosphate (S1P) associated with complex system. The present study investigated a possible involvement of SPHK1 VSMC calcification. Experiments were performed primary human aortic VSMCs under conditions, pharmacological inhibition or knockdown SPNS2 (a lysolipid transporter involved cellular S1P export), as well Sphk1-deficient wild-type mice treated cholecalciferol. In VSMCs, expression was up-regulated conditions. Calcification medium osteogenic marker mRNA activity significantly augmented co-treatment inhibitor SK1-IN-1. SK1-IN-1 alone sufficient up-regulate during control Similarly, PF-543 aggravated contrast, SLF1081851 suppressed abolished silencing SPHK1. addition, Sphk1 deficiency after cholecalciferol overload. conclusion, inhibition, knockdown, aggravates reduced export suggests intracellular S1P, but further studies are required elucidate roles SPHKs calcifying VSMCs.

Язык: Английский

Процитировано

1
The role of the intestinal microbiome in cognitive decline in patients with kidney disease DOI Creative Commons
Carsten A. Wagner, Isabelle Frey‐Wagner, Alberto Ortíz

и другие.

Nephrology Dialysis Transplantation, Год журнала: 2025, Номер 40(Supplement_2), С. ii4 - ii17

Опубликована: Март 1, 2025

ABSTRACT Cognitive decline is frequently seen in patients with chronic kidney disease (CKD). The causes of cognitive these are likely to be multifactorial, including vascular disease, uraemic toxins, blood–brain barrier leakage, and metabolic endocrine changes. Gut dysbiosis common CKD contributes the increase toxins. However, gut microbiome modulates local systemic levels several metabolites such as short-chain fatty acids or derivatives tryptophan metabolism, neurotransmitters, endocannabinoid-like mediators, bile acids, hormones glucagon-like peptide 1 (GLP1) cholecystokinin (CCK). These factors can affect function, immunity, autonomic nervous system activity various aspects brain function. Key areas include integrity, nerve myelination survival/proliferation, appetite, metabolism thermoregulation, mood, anxiety depression, stress inflammation. Alterations composition microbiota production biologically active well documented favoured by low-fiber diets, elevated urea levels, sedentary lifestyles, slow stool transit times polypharmacy. In turn, modulate function processes, discussed this review. Thus, may contribute alterations cognition a target for therapeutic interventions using diet, prebiotics probiotics.

Язык: Английский

Процитировано

1
Ginger: A complementary approach for management of cardiovascular diseases DOI
Nazanin Momeni Roudsari, Naser‐Aldin Lashgari, Saeideh Momtaz

и другие.

BioFactors, Год журнала: 2021, Номер 47(6), С. 933 - 951

Опубликована: Авг. 13, 2021

Cardiovascular disease (CVD) is a leading cause of morbidity and mortality worldwide. Inflammation oxidative stress play critical roles in progression various types CVD. Broad pharmacological properties ginger (the rhizome Zingiber officinale) its bioactive components have been reported, suggesting that they can be therapeutic choice for clinical use. Consistent with rich phenolic content, the anti-inflammatory antioxidant confirmed many studies. Ginger modifies cellular processes particular was shown to potent inhibitory effects against nuclear factor kappa B (NF-κB); signal transducer activator transcription; NOD-, LRR-, pyrin domain-containing proteins; toll-like receptors; mitogen-activated protein kinase; mammalian target rapamycin signaling pathways. also blocks pro-inflammatory cytokines activation immune system. suppresses activity molecules such as reactive oxygen species, inducible nitric oxide synthase, superoxide dismutase, glutathione, heme oxygenase, GSH-Px. In this report, we summarize biochemical pathologies underpinning variety CVDs components, including 6-shogaol, 6-gingerol, 10-dehydrogingerdione. The mechanism action, biological functions, side effects, methods enhanced cell delivery are discussed. Together preclinical studies, positive CVD support undertaking further vivo especially

Язык: Английский

Процитировано

30