Journal of Clinical Investigation,
Journal Year:
2023,
Volume and Issue:
133(11)
Published: April 20, 2023
Renal
osteodystrophy
(ROD)
is
a
disorder
of
bone
metabolism
that
affects
virtually
all
patients
with
chronic
kidney
disease
(CKD)
and
associated
adverse
clinical
outcomes
including
fractures,
cardiovascular
events,
death.
In
this
study,
we
showed
hepatocyte
nuclear
factor
4α
(HNF4α),
transcription
mostly
expressed
in
the
liver,
also
bone,
osseous
HNF4α
expression
was
dramatically
reduced
mice
ROD.
Osteoblast-specific
deletion
Hnf4α
resulted
impaired
osteogenesis
cells
mice.
Using
multi-omics
analyses
bones
lacking
or
overexpressing
Hnf4α1
Hnf4α2,
HNF4α2
main
isoform
regulates
osteogenesis,
cell
metabolism,
As
result,
osteoblast-specific
overexpression
Hnf4α2
prevented
loss
CKD.
Our
results
transcriptional
regulator
implicated
development
Nephrology Dialysis Transplantation,
Journal Year:
2023,
Volume and Issue:
39(2), P. 190 - 201
Published: Sept. 2, 2023
Phosphorus
is
an
essential
mineral
that
is,
in
the
form
of
inorganic
phosphate
(Pi),
required
for
building
cell
membranes,
DNA
and
RNA
molecules,
energy
metabolism,
signal
transduction
pH
buffering.
In
bone,
Pi
bone
stability
apatite.
Intestinal
absorption
dietary
depends
on
its
bioavailability
has
two
distinct
modes
active
transcellular
passive
paracellular
absorption.
Active
transport
transporter
mediated
partly
regulated,
while
mostly
bioavailability.
Renal
excretion
controls
systemic
levels,
transporters
proximal
tubule
highly
regulated.
Deposition
release
into
from
soft
tissues
to
be
tightly
controlled.
The
endocrine
network
coordinating
intestinal
absorption,
renal
turnover
integrates
intake
metabolic
requirements
with
critical
cardiovascular
health
during
states
hypophosphataemia
or
hyperphosphataemia
as
evident
inborn
acquired
diseases.
This
review
provides
integrated
overview
biology
mammals.
Pflügers Archiv - European Journal of Physiology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 3, 2025
Medial
vascular
calcification
is
common
in
chronic
kidney
disease
patients
and
linked
to
hyperphosphatemia.
Upon
phosphate
exposure,
intricate
signaling
events
orchestrate
pro-calcific
effects
the
vasculature
mediated
by
smooth
muscle
cells
(VSMCs).
Sphingosine
kinase
1
(SPHK1)
produces
sphingosine-1-phosphate
(S1P)
associated
with
complex
system.
The
present
study
investigated
a
possible
involvement
of
SPHK1
VSMC
calcification.
Experiments
were
performed
primary
human
aortic
VSMCs
under
conditions,
pharmacological
inhibition
or
knockdown
SPNS2
(a
lysolipid
transporter
involved
cellular
S1P
export),
as
well
Sphk1-deficient
wild-type
mice
treated
cholecalciferol.
In
VSMCs,
expression
was
up-regulated
conditions.
Calcification
medium
osteogenic
marker
mRNA
activity
significantly
augmented
co-treatment
inhibitor
SK1-IN-1.
SK1-IN-1
alone
sufficient
up-regulate
during
control
Similarly,
PF-543
aggravated
contrast,
SLF1081851
suppressed
abolished
silencing
SPHK1.
addition,
Sphk1
deficiency
after
cholecalciferol
overload.
conclusion,
inhibition,
knockdown,
aggravates
reduced
export
suggests
intracellular
S1P,
but
further
studies
are
required
elucidate
roles
SPHKs
calcifying
VSMCs.
Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: Feb. 25, 2025
Serum
phosphate
levels
are
strongly
correlated
with
the
prognosis
of
septic
patients.
However,
previous
studies
have
concentrated
on
individual
levels,
and
relationship
between
change
trends
in
serum
in-hospital
mortality
has
seldom
been
reported.
We
aimed
to
investigate
whether
level
were
associated
mortality.
classified
patients
using
k-means
clustering
analysis
into
clusters
changes
used
logistic
regressions
explore
relationships
different
mortality,
taking
cluster
smallest
as
a
reference.
Restricted
cubic
spline
regression
was
examine
shape
correlation
Subgroup
analyses
interaction
performed
discover
potential
impact
factors.
A
total
1810
(21.1%)
8586
participants
died
during
their
hospital
stay.
After
adjustment
for
baseline
variables,
2
(OR
1.303,
95%
CI
1.101–1.542,
p
=
0.002),
3
1.348,
1.158–1.57,
<
0.001),
4
1.652,
1.225–2.222,
0.001)
5
2.745,
2.212–3.407,
remained
significantly
increased
The
linear
according
restricted
regression.
According
subgroup
analyses,
ORs
female
mechanical
ventilation
lower
than
those
counterparts
across
all
clusters.
Multiplicative
additive
interactions
detected
ventilation.
First,
high
unstable
is
Second,
elevated
treatments
may
reduce
Third,
an
increasing
trend
be
more
important
predicting
poor
Nephrology Dialysis Transplantation,
Journal Year:
2025,
Volume and Issue:
40(Supplement_2), P. ii4 - ii17
Published: March 1, 2025
ABSTRACT
Cognitive
decline
is
frequently
seen
in
patients
with
chronic
kidney
disease
(CKD).
The
causes
of
cognitive
these
are
likely
to
be
multifactorial,
including
vascular
disease,
uraemic
toxins,
blood–brain
barrier
leakage,
and
metabolic
endocrine
changes.
Gut
dysbiosis
common
CKD
contributes
the
increase
toxins.
However,
gut
microbiome
modulates
local
systemic
levels
several
metabolites
such
as
short-chain
fatty
acids
or
derivatives
tryptophan
metabolism,
neurotransmitters,
endocannabinoid-like
mediators,
bile
acids,
hormones
glucagon-like
peptide
1
(GLP1)
cholecystokinin
(CCK).
These
factors
can
affect
function,
immunity,
autonomic
nervous
system
activity
various
aspects
brain
function.
Key
areas
include
integrity,
nerve
myelination
survival/proliferation,
appetite,
metabolism
thermoregulation,
mood,
anxiety
depression,
stress
inflammation.
Alterations
composition
microbiota
production
biologically
active
well
documented
favoured
by
low-fiber
diets,
elevated
urea
levels,
sedentary
lifestyles,
slow
stool
transit
times
polypharmacy.
In
turn,
modulate
function
processes,
discussed
this
review.
Thus,
may
contribute
alterations
cognition
a
target
for
therapeutic
interventions
using
diet,
prebiotics
probiotics.
Food and Agricultural Immunology,
Journal Year:
2024,
Volume and Issue:
35(1)
Published: Dec. 19, 2024
Background:
Regional
lifestyles
influence
allergic
disease
risks,
with
dietary
factors
being
crucial.
However,
observational
studies
on
micro-
and
macronutrient
impacts
are
inconsistent.
