Опубликована: Окт. 26, 2022
I got to know many people, animals, and places that, each in their own way, directly or indirectly, were the reason was able keep moving travel thus far.I met with nothing less than friendship, kindness, support; more ever imagined could deserve.To them, hold my deepest gratitude respect.I have an immeasurable appreciation by guidance example Alicia Kowaltowski has offered me.She very first supervisor when started
Язык: Английский
Advanced Science, Год журнала: 2024, Номер 11(15)
Опубликована: Фев. 11, 2024
Abstract Overproduction of reactive oxygen species (ROS), metal ion accumulation, and tricarboxylic acid cycle collapse are crucial factors in mitochondria‐mediated cell death. However, the highly adaptive nature damage‐repair capabilities malignant tumors strongly limit efficacy treatments based on a single treatment mode. To address this challenge, self‐reinforced bimetallic Mito‐Jammer is developed by incorporating doxorubicin (DOX) calcium peroxide (CaO 2 ) into hyaluronic (HA) ‐modified metal‐organic frameworks (MOF). After cellular, dissociates CaO Cu 2+ tumor microenvironment. The exposed further yields hydrogen (H O Ca weakly acidic environment to strengthen ‐based Fenton‐like reaction. Furthermore, combination chemodynamic therapy overload exacerbates ROS storms mitochondrial damage, resulting downregulation intracellular adenosine triphosphate (ATP) levels blocking Cu‐ATPase sensitize cuproptosis. This multilevel interaction strategy also activates robust immunogenic death suppresses metastasis simultaneously. study presents multivariate model for revolutionizing mitochondria relying continuous retention ions boost cuproptosis/immunotherapy cancer.
Язык: Английский
Процитировано
37
Journal of Neurochemistry, Год журнала: 2025, Номер 169(2)
Опубликована: Фев. 1, 2025
Astrocytes are glial cells recognized for their diverse roles in regulating brain circuit structure and function. They can sense adapt to changes the microenvironment due unique structural biochemical properties. A key aspect of astrocytic function involves calcium (Ca2+)-dependent signaling, which serves as a fundamental mechanism interactions with neurons other brain. However, while significant progress has been made understanding spatio-temporal properties Ca2+ signals, downstream molecular pathways exact mechanisms through astrocytes decode these signals regulate homeostatic physiological processes remain poorly understood. To address this topic, we review here available literature on sources intracellular Ca2+, well its signaling pathways. We well-studied Ca2+-dependent exocytosis but draw attention additional that less understood are, most likely, highly influential many cellular functions. Finally, how is thought underlie neuron-astrocyte regions involved cognitive processing.
Язык: Английский
Процитировано
1
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Год журнала: 2025, Номер unknown, С. 167839 - 167839
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
1
Neurobiology of Disease, Год журнала: 2024, Номер 199, С. 106550 - 106550
Опубликована: Июнь 6, 2024
Bioenergetics describe the biochemical processes responsible for energy supply in organisms. When these changes become dysregulated brain development, multiple neurodevelopmental diseases can occur, implicating bioenergetics as key regulators of neural development. Historically, discovery disease affecting individual stages development has revealed critical roles that play generating nervous system. Bioenergetic-dependent disorders include tube closure defects, microcephaly, intellectual disability, autism spectrum disorders, epilepsy, mTORopathies, and oncogenic processes. Developmental timing cell-type specificity determine long-term effects bioenergetic mechanisms on form function. Here, we discuss metabolic progenitor specification, neuronal differentiation (neurogenesis), gliogenesis. In general, transitions between glycolysis oxidative phosphorylation are regulated early oncogenesis, reactive oxygen species (ROS) mitochondrial maturity later differentiation. We also how interface with developmental regulation other elements, including cerebrospinal fluid environment. While questions remain about interplay this review integrates current state known intersections health disease.
Язык: Английский
Процитировано
5
Pharmacological Research, Год журнала: 2024, Номер 203, С. 107162 - 107162
Опубликована: Март 28, 2024
In American men, the incidence of prostate cancer (PC) is highest among all types cancer, making it second leading cause mortality associated with cancer. For advanced or metastatic PC, antiandrogen therapies are standard treatment options. The administration these treatments unfortunately carries potential risk inducing neuroendocrine (NEPC). Neuroendocrine differentiation (NED) serves as a crucial indicator development, encompassing various factors such phosphatidylinositol 3-kinase/protein kinase B/mammalian target rapamycin (PI3K/AKT/mTOR), Yes-associated protein 1 (YAP1), AMP-activated (AMPK), miRNA. processes autophagy and ferroptosis (an iron-dependent form programmed cell death) play pivotal roles in regulation cancers. Clinical trials preclinical investigations have been conducted on many signaling pathways during development NEPC, deepening research, appear to be for regulating NEPC. Due dual nature gaining deeper understanding developmental programs achieving may enhance stratification efficacy patients
Язык: Английский
Процитировано
4
Free Radical Biology and Medicine, Год журнала: 2024, Номер 219, С. 195 - 214
Опубликована: Апрель 25, 2024
Язык: Английский
Процитировано
4
Cellular Signalling, Год журнала: 2024, Номер 117, С. 111123 - 111123
Опубликована: Фев. 27, 2024
Язык: Английский
Процитировано
3
World Journal of Gastrointestinal Surgery, Год журнала: 2025, Номер 17(3)
Опубликована: Фев. 24, 2025
BACKGROUND Serum calcium ion (Ca2+) is an economical and readily available indicator as a routine screening test for hospitalized patients. There are no studies related to serum Ca2+ level digestive tract malignancy. AIM To evaluate the effectiveness of in predicting prognosis patients with colorectal cancer (CRC). METHODS We retrospectively collected data 280 diagnosed CRC who underwent radical surgery at Affiliated Cancer Hospital Xinjiang Medical University. By analyzing clinicopathological features, differences between concentrations on first day after were determined. used receiver operating characteristic curve assess predictive ability survival. Survival analyses performed using Kaplan-Meier method, multivariate Cox proportional risk regression was determine association calibration levels survival outcomes. RESULTS analysis, ideal threshold value postoperative delta (δCa2+) 1.975 0.245, respectively. Overall (OS) progression-free (PFS) better both high group δCa2+ day. The variables identified through univariate analysis incorporated into showed that tumor differentiation (P = 0.047), T stage 0.019), N < 0.001), nerve vascular invasion 0.037), carcinoembryonic antigen 0.039), baseline 0.011), 0.006) independent predictors undergoing feasible surgery. Using findings from multifactorial we developed nomogram good ability. CONCLUSION Low factor OS PFS CRC.
Язык: Английский
Процитировано
0
Molecular Neurobiology, Год журнала: 2025, Номер unknown
Опубликована: Май 26, 2025
Язык: Английский
Процитировано
0
Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 175, С. 116775 - 116775
Опубликована: Май 21, 2024
Gestational diabetes mellitus (GDM) is a pregnancy-specific disease characterized by impaired glucose tolerance during pregnancy. Although diagnosis and clinical management have improved significantly, there are still areas where therapeutic approaches need further improvement. Recent evidence suggests that CCL2, chemokine involved in immunoregulatory inflammatory processes, closely related to GDM. However, the potential value for applications mechanism of CCL2 adipose tissue macrophages (ATMs) GDM remain be elucidated. Here, we found was enriched visceral from women HFD-induced mice. The combination vitro vivo experiments showed Ccl2 silencing inhibited response macrophage blocking calcium transport between ER mitochondria reducing excessive ROS generation. Additionally, ATS-9R/siCcl2 oligopeptide complex targeting created. Under delivery ATS-9R peptide, siRNA expressed ATMs, which reduces inflammation and, as result, mitigates insulin resistance. All these findings point possibility complex, targets tissue, able reduce resistance macrophages. seems viable treatment pregnancies.
Язык: Английский
Процитировано
2