Research Square (Research Square),
Год журнала:
2023,
Номер
unknown
Опубликована: Сен. 18, 2023
Abstract
Lipid
droplets
(LDs)
are
crucial
organelles
in
organisms
and
hold
a
critical
function
modulating
intracellular
lipid
metabolism
bioenergetic
regulation.
The
homeostasis
of
LDs
directly
participates
the
onset
progression
non-alcoholic
steatohepatitis
(NASH)
other
metabolic
disorders.
However,
no
pharmacological
approaches
have
been
developed
to
target
LDs-related
dysfunction
for
diseases.
Here,
we
systemically
screened
biocompatible
nanoparticles
anti-LDs
formation
capacities,
identified
carboxyl
fullerene
derivative,
named
four
malonate
groups-substituted
C
70
(QF70),
as
most
potent
lead.
Notably,
QF70
could
be
internalized
into
hepatocytes
facilitate
lysosomal
degradation
perilipin-2
(PLIN2),
key
molecule
stability.
More
importantly,
oral
administration
robustly
blocked
both
diet-
Leptin
deficiency-induced
NASH
development
with
significant
improvement
obesity
insulin
resistance.
We
further
validated
clinical
application
potential
related
disorders
non-primate
model.
To
our
knowledge,
this
is
first-in-class
demonstration
nanoparticle
based
agent
homeostasis-targeted
therapeutic
treat
Applied Biochemistry and Biotechnology,
Год журнала:
2023,
Номер
196(1), С. 85 - 98
Опубликована: Апрель 26, 2023
Abstract
New
and
creative
methodologies
for
the
fabrication
of
silver
nanoparticles
(Ag-NPs),
which
are
exploited
in
a
wide
range
consumer
items,
significant
interest.
Hence,
this
research
emphasizes
biological
approach
Ag-NPs
through
Egyptian
henna
leaves
(
Lawsonia
inermis
Linn.)
extracts
analysis
prepared
Ag-NPs.
Plant
extract
components
were
identified
by
gas
chromatography
mass
spectrometry
(GC-mass).
The
analyses
carried
out
UV–visible
(UV–Vis),
X-ray
diffraction
(XRD),
transmission
electron
microscope
(TEM),
scanning
(SEM),
Fourier
transform
infrared
(FTIR)
analysis.
UV–Vis
reveals
that
have
maximum
peak
at
460
nm
visible
light.
Structural
characterization
recorded
peaks
corresponded
to
Bragg’s
diffractions
nano-crystal,
with
average
crystallite
sizes
varying
from
28
60
nm.
Antibacterial
activities
examined,
it
is
observed
all
microorganisms
very
sensitive
biologically
synthesized
Microorganisms,
Год журнала:
2023,
Номер
11(4), С. 1006 - 1006
Опубликована: Апрель 12, 2023
The
current
investigation
addressed
the
green
synthesis
of
silver
nanoparticles
(AgNPs)
using
newly
isolated
silver-resistant
rare
actinomycetes,
Glutamicibacter
nicotianae
SNPRA1
and
Leucobacter
aridicollis
SNPRA2,
investigated
their
impact
on
mycotoxigenic
fungi
Aspergillus
flavus
ATCC
11498
ochraceus
60532.
formation
AgNPs
was
evidenced
by
reaction's
color
change
to
brownish
appearance
characteristic
surface
plasmon
resonance.
transmission
electron
microscopy
biogenic
produced
G.
L.
SNPRA2
(designated
Gn-AgNPs
La-AgNPs,
respectively)
revealed
generation
monodispersed
spherical
with
average
sizes
8.48
±
1.72
nm
9.67
2.64
nm,
respectively.
Furthermore,
XRD
patterns
reflected
crystallinity
FTIR
spectra
demonstrated
presence
proteins
as
capping
agents.
Both
bioinspired
exhibited
a
remarkable
inhibitory
effect
conidial
germination
fungi.
caused
an
increase
in
DNA
protein
leakage,
suggesting
disruption
membrane
permeability
integrity.
Interestingly,
completely
inhibited
production
total
aflatoxins
ochratoxin
A
at
concentrations
less
than
8
μg/mL.
At
same
time,
cytotoxicity
investigations
low
toxicity
against
human
skin
fibroblast
(HSF)
cell
line.
feasible
biocompatibility
HSF
cells
up
10
μg/mL
IC50
values
were
31.78
25.83
for
present
work
sheds
light
antifungal
prospect
actinomycetes
promising
candidates
combat
mycotoxin
food
chains
nontoxic
doses.
Micro & Nano Letters,
Год журнала:
2023,
Номер
18(6)
Опубликована: Июнь 1, 2023
Abstract
The
zinc
oxide‐silver
oxide
nanocomposite
(ZnO.Ag
2
O
3
particles)
was
prepared
by
using
an
aqueous
plant
extract
of
Haplophyllum
obtusifolium
for
the
first
time.
Powder
X‐ray
diffraction
(PXRD),
Fourier
transforms
spectroscopy
(FTIR),
field
emission
microscopy
(FESEM),
energy
dispersive
analysis
(EDX),
and
transmission
electron
(TEM)
were
applied
to
analyze
structure,
functional
groups,
morphology,
purity
nanocomposite.
PXRD
revealed
formulation
ZnO.Ag
particles.
investigation
groups
has
demonstrated
presence
some
carbonated
impurities
along
with
absorbed
water
in
composition
Morphologically,
particles
have
formed
a
petal‐like
shape
different
sizes.
EDX
also
confirmed
sample
4.78%
silver
formula.
Additionally,
TEM
spherical
rectangular
shapes
particle
size
80.43
±
46.73
nm.
Moreover,
used
against
cancer
cells,
which
shown
synthesized
NCs
toxic
effect
liver
cells
concentration
time‐dependent
manner.
Heliyon,
Год журнала:
2023,
Номер
9(4), С. e15326 - e15326
Опубликована: Апрель 1, 2023
Caries
is
the
most
prevalent
and
widespread
chronic
oral
disease.
Traditional
caries
filling
materials,
due
to
their
lack
of
anti-caries
capabilities,
can
readily
develop
secondary
caries.
Nanomaterials
proposed
as
an
effective
approach
for
treatment
inhibit
biofilm
formation.
It
also
not
only
reduce
demineralization
but
promote
remineralization.
In
recent
years,
nanotechnology
in
particularly
nano-adhesive
nano-composite
resin,
has
advanced
rapidly.
Because
inorganic
nanoparticles
(NPs)
interfere
with
bacterial
metabolism
development,
NPs
have
emerged
a
new
trend
dental
applications.
Metal
metal
oxide
by
releasing
ions,
oxidative
stress
induction,
non-oxidative
mechanisms
showed
significant
antimicrobial
activity.
For
applying
anti
agents,
silver,
zinc,
titanium,
copper,
calcium
ions
been
shown
attention.
Moreover,
fluoride
functionalized
were
employed
improve
efficacy
them.
The
fluoride-functionalized
remineralization,
enhancing
apatite
this
review,
we
provided
overview
advances
use
agents.
Furthermore,
antimicrobial,
remineralizing,
mechanical
impacts
on
materials
discussed.
IET Nanobiotechnology,
Год журнала:
2022,
Номер
16(7-8), С. 284 - 294
Опубликована: Авг. 30, 2022
Developing
biosynthesis
of
silver
nanoparticles
(Ag-NPs)
using
plant
extract
is
an
environmentally
friendly
method
to
reduce
the
use
harmful
chemical
substances.
The
green
synthesis
Ag-NPs
by
Lawsonia
inermis
and
its
cellular
toxicity
antimicrobial
effect
was
studied.
physical
properties
synthesised
were
investigated
UV-visible
spectroscopy,
infrared
X-ray
diffraction
(XRD),
scanning,
transmission
electron
microscopy.
average
size
40
nm.
XRD
result
shows
peaks
at
2θ
=
38.07°,
44.26°,
64.43°,
77.35°
are
related
FCC
structure
Ag-NPs.
Cytotoxicity
evaluated
MTT
test
on
breast
cancer
MCF7
cell
line.
Observations
showed
that
cytotoxicity
studied
line
depended
concentration
time.
obtained
IC50
considered
for
cells
a
dose
250
μg/ml.
Growth
survival
rates
decreased
exponentially
with
dose.
Antimicrobial
against
Escherichia
coli,
Salmonella
typhimurium,
Bacillus
cereus,
Staphylococcus
aureus
calculate
minimum
inhibitory
bactericidal
(MBC).
results
have
properties.
lowest
can
inhibit
growth
bacterial
strains
25
Journal of Pharmacy And Bioallied Sciences,
Год журнала:
2024,
Номер
16(Suppl 2), С. S1274 - S1280
Опубликована: Апрель 1, 2024
A
BSTRACT
Background:
The
present
study,
plant
extract
to
biosynthesize
silver
nanoparticles
(AgNPs),
is
an
environmentally
benign
way
lessen
the
use
of
dangerous
chemicals.
Aims
and
Objectives:
antibacterial
effects
green
production
AgNPs
by
Lawsonia
inermis
were
examined.
Materials
Methods:
Utilizing
scanning,
transmission
electron
microscopy,
X-ray
diffraction
(XRD),
ultraviolet-visible
spectroscopy,
infrared
researchers
examined
physical
chemical
characteristics
synthesized
AgNPs.
Results:
Ag-NPs
have
highest
peak
in
visible
light
at
460
nm,
according
UV-vis
analysis.
When
nanocrystals
structurally
characterized,
peaks
that
matched
Bragg’s
diffractions
found,
with
average
crystallite
sizes
ranging
from
28
60
nm.
Examining
Ag-NPs’
properties,
it
was
shown
all
microbes
are
extremely
sensitive
these
biologically
produced
Ag-NPs.
Conclusion:
Escherichia
coli,
Salmonella
typhi,
Bacillus
cereus,
Staphylococcus
aureus
tested
for
antimicrobial
properties
synthesized.
Phytochemistry Reviews,
Год журнала:
2024,
Номер
unknown
Опубликована: Апрель 24, 2024
Abstract
The
increase
in
cases
of
various
cancers,
the
number
cancer
patients,
and
serious
side
effects
current
chemical
treatments
have
encouraged
researchers
to
discover
novel
more
effective
drugs
from
plant
sources.
In
this
review,
PubMed
Scopus
were
searched
for
English-language
peer-reviewed
articles
published
since
1994,
using
keywords:
Medicinal
plants,
Egypt,
Cancer.
inclusion
criteria
systematic
review
English
original
research
articles.
A
total
286
studies
included.
Studies
shown
that
active
compounds
certain
plants
can
anticancer
activities
by
mechanisms,
such
as
cell
cycle
arrest,
apoptosis
induction,
antioxidant
effects.
Additionally,
it
is
evident
medicinal
act
inhibitors
cells.
Plants
also
immune
checkpoint
inhibitors,
which
inhibit
proteins
PD-L1
on
tumor
cells,
PD-1
CTLA-4
T
help
regulate
responses.
This
discusses
efficacy
nanoparticles
these
against
findings
indicate
high
potential
investigating
bioactive
components
Egyptian
advancing
are
combating
cancer.
extracts
detailed
could
provide
foundation
further
clinical
trials
be
conducted,
develop
new
drugs.
