Frontiers in Immunology,
Год журнала:
2022,
Номер
13
Опубликована: Июль 15, 2022
Commensal
bacteria
and
other
microorganisms
that
reside
in
the
human
body
are
closely
associated
with
development
treatment
of
cancers.
Recently,
tumor
microbiome
(TM)
has
been
identified
a
variety
cancers
such
as
pancreatic,
lung,
breast
TM
different
compositions
tumors
effects
on
tumors.
plays
an
important
role
formation
microenvironment,
regulation
local
immunity,
modification
cell
biology,
directly
affects
efficacy
drug
for
is
expected
to
be
biomarker
tumors,
engineered
tumor-targeting
anti-cancer
microbial
agents
(GEN-001)
have
This
paper
reviews
relevant
studies
recent
years
describes
its
distribution
correlation
clinical
features,
effect
research
directions
treatment.
The
malignant
tumor
is
a
multi-etiological,
systemic
and
complex
disease
characterized
by
uncontrolled
cell
proliferation
distant
metastasis.
Anticancer
treatments
including
adjuvant
therapies
targeted
are
effective
in
eliminating
cancer
cells
but
limited
number
of
patients.
Increasing
evidence
suggests
that
the
extracellular
matrix
(ECM)
plays
an
important
role
development
through
changes
macromolecule
components,
degradation
enzymes
stiffness.
These
variations
under
control
cellular
components
tissue
via
aberrant
activation
signaling
pathways,
interaction
ECM
to
multiple
surface
receptors,
mechanical
impact.
Additionally,
shaped
regulates
immune
which
results
suppressive
microenvironment
hinders
efficacy
immunotherapies.
Thus,
acts
as
barrier
protect
from
supports
progression.
Nevertheless,
profound
regulatory
network
remodeling
hampers
design
individualized
antitumor
treatment.
Here,
we
elaborate
on
composition
ECM,
discuss
specific
mechanisms
remodeling.
Precisely,
highlight
impact
development,
proliferation,
anoikis,
metastasis,
angiogenesis,
lymphangiogenesis,
escape.
Finally,
emphasize
"normalization"
potential
strategy
for
anti-malignant
Journal of Hematology & Oncology,
Год журнала:
2022,
Номер
15(1)
Опубликована: Апрель 29, 2022
The
gut
microbiota
have
long
been
recognized
to
play
a
key
role
in
human
health
and
disease.
Currently,
several
lines
of
evidence
from
preclinical
clinical
research
gradually
established
that
the
can
modulate
antitumor
immunity
affect
efficacy
cancer
immunotherapies,
especially
immune
checkpoint
inhibitors
(ICIs).
Deciphering
underlying
mechanisms
reveals
reprogram
tumor
microenvironment
(TME)
by
engaging
innate
and/or
adaptive
cells.
Notably,
one
primary
modes
which
is
means
metabolites,
are
small
molecules
could
spread
their
initial
location
impact
local
systemic
response
promote
ICI
efficiency.
Mechanistic
exploration
provides
novel
insights
for
developing
rational
microbiota-based
therapeutic
strategies
manipulating
microbiota,
such
as
fecal
transplantation
(FMT),
probiotics,
engineered
microbiomes,
specific
microbial
augment
advance
age
utilization
precision
medicine.
Journal for ImmunoTherapy of Cancer,
Год журнала:
2021,
Номер
9(12), С. e003334 - e003334
Опубликована: Дек. 1, 2021
The
gut
microbiome
is
associated
with
the
response
to
immunotherapy
for
different
cancers.
However,
impact
of
on
hepatobiliary
cancers
receiving
remains
unknown.
This
study
aims
investigate
relationship
between
and
clinical
anti-programmed
cell
death
protein
1
(PD-1)
in
patients
advanced
cancers.Patients
unresectable
hepatocellular
carcinoma
or
biliary
tract
who
have
progressed
from
first-line
chemotherapy
(gemcitabine
plus
cisplatin)
were
enrolled.
Fresh
stool
samples
collected
before
during
anti-PD-1
treatment
analyzed
metagenomic
sequencing.
Significantly
differentially
enriched
taxa
prognosis
identified.
Kyoto
Encyclopedia
Genes
Genomes
database
MetaCyc
further
applied
annotate
explore
potential
mechanism
influencing
cancer
immunotherapy.In
total,
65
included
this
study.
Seventy-four
significantly
benefit
(CBR)
group
40
non-clinical
(NCB)
group.
Among
these
taxa,
higher
abundance
Lachnospiraceae
bacterium-GAM79
Alistipes
sp
Marseille-P5997,
which
CBR
group,
achieved
longer
progression-free
survival
(PFS)
overall
(OS)
than
lower
abundance.
Higher
Ruminococcus
calidus
Erysipelotichaceae
bacterium-GAM147
was
also
observed
better
PFS.
In
contrast,
worse
PFS
OS
found
Veillonellaceae,
NCB
Functional
annotation
indicated
that
energy
metabolism
while
amino
acid
metabolism,
may
modulate
addition,
immunotherapy-related
adverse
events
affected
by
diversity
relative
abundance.We
demonstrate
Taxonomic
signatures
responders
are
effective
biomarkers
predict
immunotherapy,
might
provide
a
new
therapeutic
target
immunotherapy.
Gastroenterology,
Год журнала:
2022,
Номер
164(2), С. 198 - 213
Опубликована: Окт. 27, 2022
Accumulating
evidence
supports
not
only
the
functional
role
of
gut
microbiome
in
cancer
development
and
progression
but
also
its
defining
efficacy
toxicity
chemotherapeutic
agents
(5-fluorouracil,
cyclophosphamide,
irinotecan,
oxaliplatin,
gemcitabine,
methotrexate)
immunotherapeutic
compounds
(anti–programmed
death-ligand
1/anti–programmed
cell
death
protein
1
anti–cytotoxic
T-lymphocyte-associated
antigen
4).
This
is
supported
numerous
vitro,
animal,
clinical
studies
that
highlight
importance
microbial
mechanisms
therapeutic
responses.
The
therefore
shapes
oncologic
outcomes
now
being
leveraged
for
novel
personalized
approaches
treatment.
However,
if
to
be
successfully
translated
into
next-generation
treatments,
a
new
multimodal
model
oncomicrobiome
must
conceptualized
incorporates
cometabolism
pharmacologic
care.
objective
this
review
outline
current
knowledge
pharmacomicrobiomics
describe
how
multiparametric
functions
influence
treatment
response
across
types.
secondary
propose
innovative
modulating
environments
improve
therapy
diminish
toxic
effects
derived
from
antineoplastic
patient
benefit.
Periodontology 2000,
Год журнала:
2022,
Номер
89(1), С. 166 - 180
Опубликована: Март 4, 2022
Abstract
Accumulating
evidence
demonstrates
that
the
oral
pathobiont
Fusobacterium
nucleatum
is
involved
in
progression
of
an
increasing
number
tumors
types.
Thus
far,
mechanisms
underlying
tumor
exacerbation
by
F.
include
enhancement
proliferation,
establishment
a
tumor‐promoting
immune
environment,
induction
chemoresistance,
and
activation
checkpoints.
This
review
focuses
on
mediate
tumor‐specific
colonization
fusobacteria.
Elucidating
mediating
fusobacterial
tropism
promotion
might
provide
new
insights
for
development
novel
approaches
detection
treatment.
Journal of Translational Medicine,
Год журнала:
2022,
Номер
20(1)
Опубликована: Июль 6, 2022
Abstract
In
recent
years,
there
has
been
a
greater
emphasis
on
the
impact
of
microbial
populations
inhabiting
gastrointestinal
tract
human
health
and
disease.
According
to
involvement
microbiota
in
modulating
physiological
processes
(such
as
immune
system
development,
vitamins
synthesis,
pathogen
displacement,
nutrient
uptake),
any
alteration
its
composition
diversity
(i.e.,
dysbiosis)
linked
variety
pathologies,
including
cancer.
this
bidirectional
relationship,
colonization
with
various
bacterial
species
is
correlated
reduced
or
elevated
risk
certain
cancers.
Notably,
gut
microflora
could
potentially
play
direct
indirect
role
tumor
initiation
progression
by
inducing
chronic
inflammation
producing
toxins
metabolites.
Therefore,
identifying
involved
their
mechanism
action
be
beneficial
preventing
onset
tumors
controlling
advancement.
Likewise,
community
affects
anti-cancer
approaches’
therapeutic
potential
adverse
effects
immunotherapy
chemotherapy).
Hence,
efficiency
should
evaluated
context
microbiome,
underlining
importance
personalized
medicine.
review,
we
summarized
evidence
revealing
microbiota's
cancer
mechanism.
We
also
delineated
how
predict
colon
carcinoma
development
response
current
treatments
improve
clinical
outcomes.
Gut,
Год журнала:
2023,
Номер
72(7), С. 1308 - 1318
Опубликована: Фев. 8, 2023
The
protein
post-translational
modification
(PTM)
in
host
cells
can
be
rewritten
by
bacterial
enzymes
and
represents
an
unprecedented
mechanism
the
communication
between
intestinal
flora
host.
Although
Akkermansia
muciniphila
has
been
widely
investigated
as
a
probiotic
blunts
colitis-associated
tumourigenesis
mice,
there
is
little
understanding
regarding
whether
A.
involved
PTM
of
colorectal
cancer
(CRC).
This
study
investigates
how
engages
CRC.The
secreting
extracellular
vesicles
from
purified
Amuc_2172
were
used
for
different
mice
models.
Amuc_2172-induced
immune
activity
CD8+
cytotoxic
T
lymphocytes
(CTLs)
evaluated
vitro
vivo.
acetyltransferase
downstream
target
genes
investigated.Amuc_2172,
general
control
non-derepressible
5-related
muciniphila,
was
accessible
to
macropinocytosis
functioned
Lys14
on
histone
H3
(H3K14ac).
Elevated
H3K14ac
Hspa1a
loci
promoted
transcription
secretion
heat-shock
70
(HSP70)
cells.
High
level
HSP70
CTLs
Moreover,
bioengineered
nanoparticles
provided
safe
reliable
drug
delivery
strategy
CRC
treatment
allograft
model.Amuc_2172
reprogrammed
tumour
microenvironment
inducing
promoting
CTL-related
response
process
tumourigenesis.
International Journal of Environmental Research and Public Health,
Год журнала:
2023,
Номер
20(4), С. 3640 - 3640
Опубликована: Фев. 18, 2023
The
overall
burden
of
cancer
is
rapidly
increasing
worldwide,
reflecting
not
only
population
growth
and
aging,
but
also
the
prevalence
spread
risk
factors.
Gastrointestinal
(GI)
cancers,
including
stomach,
liver,
esophageal,
pancreatic,
colorectal
represent
more
than
a
quarter
all
cancers.
While
smoking
alcohol
use
are
factors
most
commonly
associated
with
development,
growing
consensus
includes
dietary
habits
as
relevant
for
GI
Current
evidence
suggests
that
socioeconomic
development
results
in
several
lifestyle
modifications,
shifts
from
local
traditional
diets
to
less-healthy
Western
diets.
Moreover,
recent
data
indicate
increased
production
consumption
processed
foods
underlies
current
pandemics
obesity
related
metabolic
disorders,
which
directly
or
indirectly
emergence
various
chronic
noncommunicable
conditions
However,
environmental
changes
restricted
patterns,
unhealthy
behavioral
features
should
be
analyzed
holistic
view
lifestyle.
In
this
review,
we
discussed
epidemiological
aspects,
gut
dysbiosis,
cellular
molecular
characteristics
cancers
explored
impact
behaviors,
diet,
physical
activity
on
developing
context
progressive
societal
changes.
