Journal of Advanced Research,
Год журнала:
2024,
Номер
unknown
Опубликована: Апрель 1, 2024
The
treatment
of
metabolic
system,
cardiovascular
and
nervous
system
diseases
remains
to
be
explored.
In
the
internal
environment
organisms,
metabolism
substances
such
as
carbohydrates,
lipids
proteins
(including
biohormones
enzymes)
exhibit
a
certain
circadian
rhythm
maintain
energy
supply
material
cycle
needed
for
normal
activities
organisms.
As
key
factor
health
can
disrupted
by
pathological
conditions,
this
disruption
accelerates
progression
results
in
vicious
cycle.
current
treatments
targeting
have
limitations,
identification
safer
more
effective
regulators
is
needed.
To
systematically
assess
possibility
using
biological
clock
natural
product
target
disease
intervention,
work
reviews
range
evidence
on
potential
effectiveness
products
protect
against
system.
This
manuscript
focuses
how
restore
function
affecting
amplitude
expression
factors,
sleep/wake
cycles
structure
gut
microbiota.
proposes
that
rhythm,
which
regulated
rhythm-related
factors
cycle,
crucial
new
slowing
through
use
products.
provides
reference
molecular
modeling
perspective
time-targeted
action
drugs.
Signal Transduction and Targeted Therapy,
Год журнала:
2023,
Номер
8(1)
Опубликована: Март 20, 2023
Metabolic
abnormalities
lead
to
the
dysfunction
of
metabolic
pathways
and
metabolite
accumulation
or
deficiency
which
is
well-recognized
hallmarks
diseases.
Metabolite
signatures
that
have
close
proximity
subject's
phenotypic
informative
dimension,
are
useful
for
predicting
diagnosis
prognosis
diseases
as
well
monitoring
treatments.
The
lack
early
biomarkers
could
poor
serious
outcomes.
Therefore,
noninvasive
methods
with
high
specificity
selectivity
desperately
needed.
Small
molecule
metabolites-based
metabolomics
has
become
a
specialized
tool
biomarker
pathway
analysis,
revealing
possible
mechanisms
human
various
deciphering
therapeutic
potentials.
It
help
identify
functional
related
variation
delineate
biochemical
changes
indicators
pathological
damage
prior
disease
development.
Recently,
scientists
established
large
number
profiles
reveal
underlying
networks
target
exploration
in
biomedicine.
This
review
summarized
analysis
on
potential
value
small-molecule
candidate
metabolites
clinical
events,
may
better
diagnosis,
prognosis,
drug
screening
treatment.
We
also
discuss
challenges
need
be
addressed
fuel
next
wave
breakthroughs.
Trends in Food Science & Technology,
Год журнала:
2023,
Номер
138, С. 178 - 198
Опубликована: Июнь 11, 2023
The
human
gut
hosts
complex
microbial
communities,
which
are
linked
to
health
and
disease.
microbiota
is
continuously
reshaped
by
multiple
environmental
factors,
especially
diet.
Gut
dysbiosis
may
promote
various
metabolic,
neurological,
intestinal,
cardiovascular
diseases,
even
tumor
development.
Probiotics
have
shown
promising
prophylactic,
mitigating,
or
curative
effects
when
use
as
nutrient
supplements
adjunctive
therapy.
These
beneficial
and/or
symptom
alleviation
often
accompanied
microbiome
metabolome
changes.
Differing
from
other
published
review
articles,
here
we
summarized
the
latest
knowledge
of
evidence-based
health-promoting
probiotics
scouring
literature
recent
animal
probiotic
intervention
studies.
To
elucidate
mechanisms
in
enhancing
intestinal
homeostasis,
barrier
function,
host
immunity,
through
modulating
its
metabolites.
Meanwhile,
also
discussed
challenges
data
analysis
clinical
research
comparison
between
laboratories,
provides
an
outlook
for
future
perspectives
applications
probiotics.
achieved
modulation.
Current
discussed.
Finally,
provided.
Signal Transduction and Targeted Therapy,
Год журнала:
2024,
Номер
9(1)
Опубликована: Янв. 10, 2024
Abstract
Human
microorganisms,
including
bacteria,
fungi,
and
viruses,
play
key
roles
in
several
physiological
pathological
processes.
Some
studies
discovered
that
tumour
tissues
once
considered
sterile
actually
host
a
variety
of
which
have
been
confirmed
to
be
closely
related
oncogenesis.
The
concept
intratumoural
microbiota
was
subsequently
proposed.
Microbiota
could
colonise
through
mucosal
destruction,
adjacent
tissue
migration,
hematogenic
invasion
affect
the
biological
behaviour
tumours
as
an
important
part
microenvironment.
Mechanistic
demonstrated
potentially
promote
initiation
progression
by
inducing
genomic
instability
mutations,
affecting
epigenetic
modifications,
promoting
inflammation
response,
avoiding
immune
regulating
metabolism,
activating
metastasis.
Since
more
comprehensive
profound
insights
about
intratumoral
are
continuously
emerging,
new
methods
for
early
diagnosis
prognostic
assessment
cancer
patients
under
examination.
In
addition,
interventions
based
on
show
great
potential
open
chapter
antitumour
therapy,
especially
immunotherapy,
although
there
some
inevitable
challenges.
Here,
we
aim
provide
extensive
review
concept,
development
history,
sources,
heterogeneity,
carcinogenic
mechanisms
explore
role
microorganisms
prognosis,
discuss
current
treatment
regimens
target
research
prospects
limitations
this
field.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(11), С. 6022 - 6022
Опубликована: Май 30, 2024
The
role
of
probiotics
in
regulating
intestinal
flora
to
enhance
host
immunity
has
recently
received
widespread
attention.
Altering
the
human
gut
microbiota
may
increase
predisposition
several
disease
phenotypes
such
as
inflammation
and
metabolic
disorders.
converts
dietary
nutrients
into
metabolites
that
serve
biologically
active
molecules
modulating
regulatory
functions
host.
Probiotics,
which
are
microorganisms,
play
a
versatile
restoring
composition
microbiota,
helping
improve
prevent
phenotypes.
This
comprehensive
review
provides
firsthand
information
on
their
influence
health,
effects
diet
how
alter
function
along
with
corresponding
building
healthy
intestine.
We
also
discuss
implications
some
most
important
diseases.
In
summary,
significant
boosting
overall
immunity,
increasing
abundance
beneficial
bacteria,
ameliorate
symptoms
multiple
Antioxidants,
Год журнала:
2024,
Номер
13(8), С. 985 - 985
Опубликована: Авг. 14, 2024
Gut
dysbiosis,
resulting
from
an
imbalance
in
the
gut
microbiome,
can
induce
excessive
production
of
reactive
oxygen
species
(ROS),
leading
to
inflammation,
DNA
damage,
activation
immune
system,
and
epigenetic
alterations
critical
genes
involved
metabolic
pathways.
dysbiosis-induced
inflammation
also
disrupt
barrier
integrity
increase
intestinal
permeability,
which
allows
gut-derived
toxic
products
enter
liver
systemic
circulation,
further
triggering
oxidative
stress,
associated
with
diseases.
However,
specific
metabolites,
such
as
short-chain
fatty
acids
(SCFAs),
lactate,
vitamins,
modulate
stress
system
through
mechanisms,
thereby
improving
function.
microbiota
diet-induced
diseases,
obesity,
insulin
resistance,
dyslipidemia,
hypertension,
transfer
next
generation,
involving
mechanisms.
In
this
review,
we
will
introduce
key
that,
along
dysbiosis
ROS,
are
engaged
developing
Finally,
discuss
potential
therapeutic
interventions
dietary
modifications,
prebiotics,
probiotics,
postbiotics,
fecal
transplantation,
may
reduce
syndrome
by
altering
alterations.
summary,
review
highlights
crucial
role
pathogenesis
a
particular
focus
on
(including
histone
methylomics,
RNA
interference)
that
prevent
or
improve
The
gut
microbiota
can
produce
a
variety
of
microbial-derived
metabolites
to
influence
tumor
development.
Tryptophan,
an
essential
amino
acid
in
the
human
body,
be
converted
by
microorganisms
via
indole
pathway
such
as
Indole-3-Lactic
Acid
(ILA),
Indole-3-Propionic
(IPA),
Indole
Acetic
(IAA)
and
Indole-3-Aldehyde
(IAld).
Recent
studies
have
shown
that
play
key
roles
progression,
they
used
adjuvant
regimens
for
immunotherapy
or
chemotherapy.
Here,
we
summarize
recent
findings
on
common
microbial
provide
review
mechanisms
different
microenvironment.
We
further
discuss
limitations
current
metabolite
research
future
possibilities.
It
is
expected
will
new
strategies
clinical
therapy.
Advances in Nutrition,
Год журнала:
2025,
Номер
unknown, С. 100416 - 100416
Опубликована: Март 1, 2025
The
circadian
rhythm
arises
endogenously
from
genetically
encoded
molecular
clocks,
wherein
the
components
collaborate
to
induce
cyclic
fluctuations,
occurring
approximately
every
24
hours.
rhythms
synchronize
biological
processes
with
regular
and
predictable
environmental
patterns
guarantee
host
metabolism
energy
homeostasis
function
well-being.
Disruptions
are
widely
associated
metabolic
disorders.
Notably,
microbial
influenced
by
both
host's
intrinsic
clock
external
rhythmic
factors
(i.e.,
light-dark
cycle,
diet
composition),
which
affect
structure
of
communities
functions.
Moreover,
microbiota
metabolites
also
reciprocally
influence
rhythms,
potentially
impacting
function.
This
review
explores
bidirectional
interactions
between
clock,
influencing
host-microbial
effects
on
lipid
homeostasis.
STATEMENT
OF
SIGNIFICANCE:
highlighting
gut
microbiota,
metabolites,
rhythms.
Additionally,
it
emphasizes
impact
disruptions
in
development
diseases.
Journal of Clinical Medicine,
Год журнала:
2023,
Номер
12(3), С. 780 - 780
Опубликована: Янв. 18, 2023
The
limitation
of
traditional
delivery
methods
for
fecal
microbiota
transplantation
(FMT)
gave
birth
to
colonic
transendoscopic
enteral
tubing
(TET)
address
the
requirement
frequent
FMTs.
Colonic
TET
as
a
novel
endoscopic
intervention
has
received
increasing
attention
in
practice
since
2015
China.
Emerging
studies
from
multiple
centers
indicate
that
is
promising,
safe,
and
practical
method
microbial
therapy
administering
medication
with
high
patient
satisfaction.
Intriguingly,
been
used
rescue
endoscopy-related
perforations
by
draining
air
fluid
through
tube.
Recent
research
based
on
collecting
ileocecal
samples
tube
contributed
demonstrating
community
dynamics
intestine,
it
expected
be
proof-of-concept
host–microbiota
interactions
pharmacological
research.
present
article
aims
review
concept
techniques
explore
therapy,
drainage,
TET.