From gut to placenta: understanding how the maternal microbiome models life-long conditions DOI Creative Commons

Jonathan Ruiz-Triviño,

Daniel Álvarez,

Ángela P. Cadavid J.

et al.

Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14

Published: Dec. 15, 2023

The microbiome -defined as the microbiota (bacteria, archaea, lower and higher eukaryotes), their genomes, surrounding environmental conditions- has a well-described range of physiological functions. Thus, an imbalance composition -dysbiosis- been associated with pregnancy complications or adverse fetal outcomes. Although there is controversy about existence absence in placenta fetus during healthy pregnancy, it known that gut can produce bioactive metabolites enter maternal circulation may be actively passively transferred through placenta. Furthermore, evidence suggests such have some effect on fetus. Since influence epigenome, modifications epigenome could responsible for programming, experimentally supported its involved programming. developmental origin health disease (DOHaD) approach looks to understand how exposure factors periods high plasticity early stages life (e.g., gestational period) influences program risk progeny. Therefore, according DOHaD approach, development must explored. Here, we described diseases adulthood related alterations microbiota. In summary, this review aims highlight both postnatal life, suggesting dysbiosis morbidity.

Language: Английский

Small molecule metabolites: discovery of biomarkers and therapeutic targets DOI Creative Commons
Shi Qiu, Ying Cai, Hong Yao

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: March 20, 2023

Metabolic abnormalities lead to the dysfunction of metabolic pathways and metabolite accumulation or deficiency which is well-recognized hallmarks diseases. Metabolite signatures that have close proximity subject's phenotypic informative dimension, are useful for predicting diagnosis prognosis diseases as well monitoring treatments. The lack early biomarkers could poor serious outcomes. Therefore, noninvasive methods with high specificity selectivity desperately needed. Small molecule metabolites-based metabolomics has become a specialized tool biomarker pathway analysis, revealing possible mechanisms human various deciphering therapeutic potentials. It help identify functional related variation delineate biochemical changes indicators pathological damage prior disease development. Recently, scientists established large number profiles reveal underlying networks target exploration in biomedicine. This review summarized analysis on potential value small-molecule candidate metabolites clinical events, may better diagnosis, prognosis, drug screening treatment. We also discuss challenges need be addressed fuel next wave breakthroughs.

Language: Английский

Citations

382
Targeting gut microbiota and metabolism as the major probiotic mechanism - An evidence-based review DOI Creative Commons
Teng Ma, Xin Shen, Xuan Shi

et al.

Trends in Food Science & Technology, Journal Year: 2023, Volume and Issue: 138, P. 178 - 198

Published: June 11, 2023

The human gut hosts complex microbial communities, which are linked to health and disease. microbiota is continuously reshaped by multiple environmental factors, especially diet. Gut dysbiosis may promote various metabolic, neurological, intestinal, cardiovascular diseases, even tumor development. Probiotics have shown promising prophylactic, mitigating, or curative effects when use as nutrient supplements adjunctive therapy. These beneficial and/or symptom alleviation often accompanied microbiome metabolome changes. Differing from other published review articles, here we summarized the latest knowledge of evidence-based health-promoting probiotics scouring literature recent animal probiotic intervention studies. To elucidate mechanisms in enhancing intestinal homeostasis, barrier function, host immunity, through modulating its metabolites. Meanwhile, also discussed challenges data analysis clinical research comparison between laboratories, provides an outlook for future perspectives applications probiotics. achieved modulation. Current discussed. Finally, provided.

Language: Английский

Citations

151
Intratumoural microbiota: a new frontier in cancer development and therapy DOI Creative Commons

Yaqi Cao,

Hui Xia,

Xueyun Tan

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Jan. 10, 2024

Abstract Human microorganisms, including bacteria, fungi, and viruses, play key roles in several physiological pathological processes. Some studies discovered that tumour tissues once considered sterile actually host a variety of which have been confirmed to be closely related oncogenesis. The concept intratumoural microbiota was subsequently proposed. Microbiota could colonise through mucosal destruction, adjacent tissue migration, hematogenic invasion affect the biological behaviour tumours as an important part microenvironment. Mechanistic demonstrated potentially promote initiation progression by inducing genomic instability mutations, affecting epigenetic modifications, promoting inflammation response, avoiding immune regulating metabolism, activating metastasis. Since more comprehensive profound insights about intratumoral are continuously emerging, new methods for early diagnosis prognostic assessment cancer patients under examination. In addition, interventions based on show great potential open chapter antitumour therapy, especially immunotherapy, although there some inevitable challenges. Here, we aim provide extensive review concept, development history, sources, heterogeneity, carcinogenic mechanisms explore role microorganisms prognosis, discuss current treatment regimens target research prospects limitations this field.

Language: Английский

Citations

75
Effects of Probiotics on Gut Microbiota: An Overview DOI Open Access
Preethi Chandrasekaran, Sabine Weiskirchen, Ralf Weiskirchen

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 6022 - 6022

Published: May 30, 2024

The role of probiotics in regulating intestinal flora to enhance host immunity has recently received widespread attention. Altering the human gut microbiota may increase predisposition several disease phenotypes such as inflammation and metabolic disorders. converts dietary nutrients into metabolites that serve biologically active molecules modulating regulatory functions host. Probiotics, which are microorganisms, play a versatile restoring composition microbiota, helping improve prevent phenotypes. This comprehensive review provides firsthand information on their influence health, effects diet how alter function along with corresponding building healthy intestine. We also discuss implications some most important diseases. In summary, significant boosting overall immunity, increasing abundance beneficial bacteria, ameliorate symptoms multiple

Language: Английский

Citations

54
Gut Microbiota Dysbiosis, Oxidative Stress, Inflammation, and Epigenetic Alterations in Metabolic Diseases DOI Creative Commons
Hamid M. Abdolmaleky, Jin‐Rong Zhou

Antioxidants, Journal Year: 2024, Volume and Issue: 13(8), P. 985 - 985

Published: Aug. 14, 2024

Gut dysbiosis, resulting from an imbalance in the gut microbiome, can induce excessive production of reactive oxygen species (ROS), leading to inflammation, DNA damage, activation immune system, and epigenetic alterations critical genes involved metabolic pathways. dysbiosis-induced inflammation also disrupt barrier integrity increase intestinal permeability, which allows gut-derived toxic products enter liver systemic circulation, further triggering oxidative stress, associated with diseases. However, specific metabolites, such as short-chain fatty acids (SCFAs), lactate, vitamins, modulate stress system through mechanisms, thereby improving function. microbiota diet-induced diseases, obesity, insulin resistance, dyslipidemia, hypertension, transfer next generation, involving mechanisms. In this review, we will introduce key that, along dysbiosis ROS, are engaged developing Finally, discuss potential therapeutic interventions dietary modifications, prebiotics, probiotics, postbiotics, fecal transplantation, may reduce syndrome by altering alterations. summary, review highlights crucial role pathogenesis a particular focus on (including histone methylomics, RNA interference) that prevent or improve

Language: Английский

Citations

54
Distribution and roles of Ligilactobacillus murinus in hosts DOI

Zhou Chuandong,

Jicong Hu,

Jiawen Li

et al.

Microbiological Research, Journal Year: 2024, Volume and Issue: 282, P. 127648 - 127648

Published: Feb. 15, 2024

Language: Английский

Citations

20
Effects of short-chain fatty acid-butyrate supplementation on expression of circadian-clock genes, sleep quality, and inflammation in patients with active ulcerative colitis: a double-blind randomized controlled trial DOI Creative Commons
Donya Firoozi, Seyed Jalil Masoumi,

Seyed Mohammad-Kazem Hosseini Asl

et al.

Lipids in Health and Disease, Journal Year: 2024, Volume and Issue: 23(1)

Published: July 13, 2024

Abstract Background The regulation of the circadian clock genes, which coordinate activity immune system, is disturbed in inflammatory bowel disease (IBD). Emerging evidence suggests that butyrate, a short-chain fatty acid produced by gut microbiota involved responses as well circadian-clock genes. This study was conducted to investigate effects sodium-butyrate supplementation on expression inflammation, sleep and life quality active ulcerative colitis (UC) patients. Methods In current randomized placebo-controlled trial, 36 UC patients were randomly divided receive (600 mg/kg) or placebo for 12-weeks. this genes (CRY1, CRY2, PER1, PER2, BMAl1 CLOCK) assessed real time polymerase chain reaction (qPCR) whole blood. Gene changes presented fold (2^-ΔΔCT) relative baseline. faecal calprotectin serum level high-sensitivity C-reactive protein (hs-CRP) enzyme-linked immunosorbent assay method (ELIZA). Moreover, IBD (QoL) Pittsburgh index (PSQI) questionnaire-9 (IBDQ-9) respectively before after intervention. Results results showed comparison with significantly decreased (-133.82 ± 155.62 vs. 51.58 95.57, P -value < 0.001) hs-CRP (-0.36 (-1.57, -0.05) 0.48 (-0.09-4.77), upregulated change CRY1 (2.22 1.59 0.63 0.49, 0.001), CRY2 (2.15 1.26 0.93 0.80, = PER1 (1.86 1.77 0.65 0.48, 0.005), BMAL1 (1.85 0.97 0.86 0.63, 0.003). Also, caused an improvement (PSQI score: -2.94 3.50 1.16 3.61, QoL (IBDQ-9: 17.00 11.36 -3.50 6.87, 0.001). Conclusion Butyrate may be effective adjunct treatment reducing biomarkers upregulation improving QoL.

Language: Английский

Citations

16
The role of microbial indole metabolites in tumor DOI Creative Commons
Dingjiacheng Jia, Zheng Kuang, Liangjing Wang

et al.

Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)

Published: Oct. 1, 2024

The gut microbiota can produce a variety of microbial-derived metabolites to influence tumor development. Tryptophan, an essential amino acid in the human body, be converted by microorganisms via indole pathway such as Indole-3-Lactic Acid (ILA), Indole-3-Propionic (IPA), Indole Acetic (IAA) and Indole-3-Aldehyde (IAld). Recent studies have shown that play key roles progression, they used adjuvant regimens for immunotherapy or chemotherapy. Here, we summarize recent findings on common microbial provide review mechanisms different microenvironment. We further discuss limitations current metabolite research future possibilities. It is expected will new strategies clinical therapy.

Language: Английский

Citations

11
Emerging Roles of Modern Lifestyle Factors in Microbiome Stability and Functionality DOI Creative Commons
Ye Yang, M. C. Carreño Hernández, Siddhi Chitre

et al.

Current Clinical Microbiology Reports, Journal Year: 2025, Volume and Issue: 12(1)

Published: March 12, 2025

Language: Английский

Citations

1
Colonic Transendoscopic Enteral Tubing Is a New Pathway to Microbial Therapy, Colonic Drainage, and Host–Microbiota Interaction Research DOI Open Access
Weihong Wang, Gaochen Lu, Xia Wu

et al.

Journal of Clinical Medicine, Journal Year: 2023, Volume and Issue: 12(3), P. 780 - 780

Published: Jan. 18, 2023

The limitation of traditional delivery methods for fecal microbiota transplantation (FMT) gave birth to colonic transendoscopic enteral tubing (TET) address the requirement frequent FMTs. Colonic TET as a novel endoscopic intervention has received increasing attention in practice since 2015 China. Emerging studies from multiple centers indicate that is promising, safe, and practical method microbial therapy administering medication with high patient satisfaction. Intriguingly, been used rescue endoscopy-related perforations by draining air fluid through tube. Recent research based on collecting ileocecal samples tube contributed demonstrating community dynamics intestine, it expected be proof-of-concept host–microbiota interactions pharmacological research. present article aims review concept techniques explore therapy, drainage, TET.

Language: Английский

Citations

22