Vat photopolymerization 3D printing for advanced drug delivery and medical device applications

Journal of Controlled Release, Год журнала: 2020, Номер 329, С. 743 - 757

Опубликована: Окт. 5, 2020

Язык: Английский

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Hollow microneedles: A perspective in biomedical applications

International Journal of Pharmaceutics, Год журнала: 2021, Номер 599, С. 120455 - 120455

Опубликована: Март 5, 2021

Язык: Английский

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3D-printed microneedles in biomedical applications

iScience, Год журнала: 2020, Номер 24(1), С. 102012 - 102012

Опубликована: Дек. 31, 2020

Conventional needle technologies can be advanced with emerging nano- and micro-fabrication methods to fabricate microneedles. Nano-/micro-fabricated microneedles seek mitigate penetration pain tissue damage, as well providing accurately controlled robust channels for administrating bioagents collecting body fluids. Here, design 3D printing strategies of are discussed applications in biomedical devices healthcare technologies. offers customization, cost-efficiency, a rapid turnaround time between iterations, enhanced accessibility. Increasing the resolution, accuracy features, accessibility low-cost raw materials have empowered utilized fabrication microneedle platforms. The development 3D-printed has enabled evolution pain-free release drug delivery systems, extracting fluids from cutaneous tissue, biosignal acquisition, point-of-care diagnostic personalized medicine.

Язык: Английский

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An on-skin platform for wireless monitoring of flow rate, cumulative loss and temperature of sweat in real time

Nature Electronics, Год журнала: 2021, Номер 4(4), С. 302 - 312

Опубликована: Март 29, 2021

Язык: Английский

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Emerging 3D printing technologies for drug delivery devices: Current status and future perspective

Advanced Drug Delivery Reviews, Год журнала: 2021, Номер 174, С. 294 - 316

Опубликована: Апрель 23, 2021

Язык: Английский

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Microneedles: Characteristics, Materials, Production Methods and Commercial Development

Micromachines, Год журнала: 2020, Номер 11(11), С. 961 - 961

Опубликована: Окт. 27, 2020

Although transdermal drug delivery systems (DDS) offer numerous benefits for patients, including the avoidance of both gastric irritation and first-pass metabolism effect, as well improved patient compliance, only a limited number active pharmaceutical ingredients (APIs) can be delivered accordingly. Microneedles (MNs) represent one most promising concepts effective that penetrate protective skin barrier in minimally invasive painless manner. The first MNs were produced 90s, since then, this field has been continually evolving. Therefore, different manufacturing methods, not but also MN molds, are introduced, which allows cost-effective production vaccine even diagnostic/monitoring purposes. focus review is to give brief overview characteristics, material composition, commercial development MN-based systems.

Язык: Английский

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Pharmaceutical Applications of 3D Printing

Additive manufacturing, Год журнала: 2020, Номер 34, С. 101209 - 101209

Опубликована: Апрель 29, 2020

Язык: Английский

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Going below and beyond the surface: Microneedle structure, materials, drugs, fabrication, and applications for wound healing and tissue regeneration

Bioactive Materials, Год журнала: 2023, Номер 27, С. 303 - 326

Опубликована: Апрель 18, 2023

Microneedle, as a novel drug delivery system, has attracted widespread attention due to its non-invasiveness, painless and simple administration, controllable delivery, diverse cargo loading capacity. Although microneedles are initially designed penetrate stratum corneum of skin for transdermal they, recently, have been used promote wound healing regeneration tissues organs the results promising. Despite there reviews about microneedles, few them focus on tissue regeneration. Here, we review recent advances in this field. We first give an overview microneedle system terms potential cargos (e.g., small molecules, macromolecules, nucleic acids, nanoparticles, extracellular vesicle, cells), structural designs multidrug structures, adhesive structures), material selection, release mechanisms. Then briefly summarize different fabrication methods, including their advantages limitations. finally progress microneedle-assisted skin, cardiac, bone, tendon, ocular, vascular, oral, hair, spinal cord, uterine tissues). expect that our article would serve guideline readers design systems according applications, structure design, achieving better efficacy.

Язык: Английский

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Current and emerging trends in polymeric 3D printed microfluidic devices

Additive manufacturing, Год журнала: 2022, Номер 55, С. 102867 - 102867

Опубликована: Май 5, 2022

Язык: Английский

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The Role of 3D Printing Technology in Microengineering of Microneedles

Small, Год журнала: 2022, Номер 18(18)

Опубликована: Март 31, 2022

Abstract Microneedles (MNs) are minimally invasive devices, which have gained extensive interest over the past decades in various fields including drug delivery, disease diagnosis, monitoring, and cosmetics. MN geometry shape key parameters that dictate performance therapeutic efficacy, however, traditional fabrication methods, such as molding, may not be able to offer rapid design modifications. In this regard, of MNs using 3D printing technology enables creation complex prototypes with high accuracy offers customizable devices a desired dimension. Moreover, shows great potential producing advanced transdermal delivery systems medical by integrating variety technologies. This review aims demonstrate advantages exploiting new tool microengineer MNs. Various methods introduced, representative manufactured approaches highlighted detail. The development is also included. Finally, clinical translation future perspectives for discussed.

Язык: Английский

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