Vat photopolymerization 3D printing for advanced drug delivery and medical device applications

Journal of Controlled Release, Journal Year: 2020, Volume and Issue: 329, P. 743 - 757

Published: Oct. 5, 2020

Language: Английский

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Hollow microneedles: A perspective in biomedical applications

International Journal of Pharmaceutics, Journal Year: 2021, Volume and Issue: 599, P. 120455 - 120455

Published: March 5, 2021

Language: Английский

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3D-printed microneedles in biomedical applications

iScience, Journal Year: 2020, Volume and Issue: 24(1), P. 102012 - 102012

Published: Dec. 31, 2020

Conventional needle technologies can be advanced with emerging nano- and micro-fabrication methods to fabricate microneedles. Nano-/micro-fabricated microneedles seek mitigate penetration pain tissue damage, as well providing accurately controlled robust channels for administrating bioagents collecting body fluids. Here, design 3D printing strategies of are discussed applications in biomedical devices healthcare technologies. offers customization, cost-efficiency, a rapid turnaround time between iterations, enhanced accessibility. Increasing the resolution, accuracy features, accessibility low-cost raw materials have empowered utilized fabrication microneedle platforms. The development 3D-printed has enabled evolution pain-free release drug delivery systems, extracting fluids from cutaneous tissue, biosignal acquisition, point-of-care diagnostic personalized medicine.

Language: Английский

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An on-skin platform for wireless monitoring of flow rate, cumulative loss and temperature of sweat in real time

Nature Electronics, Journal Year: 2021, Volume and Issue: 4(4), P. 302 - 312

Published: March 29, 2021

Language: Английский

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Emerging 3D printing technologies for drug delivery devices: Current status and future perspective

Advanced Drug Delivery Reviews, Journal Year: 2021, Volume and Issue: 174, P. 294 - 316

Published: April 23, 2021

Language: Английский

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Microneedles: Characteristics, Materials, Production Methods and Commercial Development

Micromachines, Journal Year: 2020, Volume and Issue: 11(11), P. 961 - 961

Published: Oct. 27, 2020

Although transdermal drug delivery systems (DDS) offer numerous benefits for patients, including the avoidance of both gastric irritation and first-pass metabolism effect, as well improved patient compliance, only a limited number active pharmaceutical ingredients (APIs) can be delivered accordingly. Microneedles (MNs) represent one most promising concepts effective that penetrate protective skin barrier in minimally invasive painless manner. The first MNs were produced 90s, since then, this field has been continually evolving. Therefore, different manufacturing methods, not but also MN molds, are introduced, which allows cost-effective production vaccine even diagnostic/monitoring purposes. focus review is to give brief overview characteristics, material composition, commercial development MN-based systems.

Language: Английский

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Pharmaceutical Applications of 3D Printing

Additive manufacturing, Journal Year: 2020, Volume and Issue: 34, P. 101209 - 101209

Published: April 29, 2020

Language: Английский

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Going below and beyond the surface: Microneedle structure, materials, drugs, fabrication, and applications for wound healing and tissue regeneration

Bioactive Materials, Journal Year: 2023, Volume and Issue: 27, P. 303 - 326

Published: April 18, 2023

Microneedle, as a novel drug delivery system, has attracted widespread attention due to its non-invasiveness, painless and simple administration, controllable delivery, diverse cargo loading capacity. Although microneedles are initially designed penetrate stratum corneum of skin for transdermal they, recently, have been used promote wound healing regeneration tissues organs the results promising. Despite there reviews about microneedles, few them focus on tissue regeneration. Here, we review recent advances in this field. We first give an overview microneedle system terms potential cargos (e.g., small molecules, macromolecules, nucleic acids, nanoparticles, extracellular vesicle, cells), structural designs multidrug structures, adhesive structures), material selection, release mechanisms. Then briefly summarize different fabrication methods, including their advantages limitations. finally progress microneedle-assisted skin, cardiac, bone, tendon, ocular, vascular, oral, hair, spinal cord, uterine tissues). expect that our article would serve guideline readers design systems according applications, structure design, achieving better efficacy.

Language: Английский

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Current and emerging trends in polymeric 3D printed microfluidic devices

Additive manufacturing, Journal Year: 2022, Volume and Issue: 55, P. 102867 - 102867

Published: May 5, 2022

Language: Английский

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The Role of 3D Printing Technology in Microengineering of Microneedles

Small, Journal Year: 2022, Volume and Issue: 18(18)

Published: March 31, 2022

Abstract Microneedles (MNs) are minimally invasive devices, which have gained extensive interest over the past decades in various fields including drug delivery, disease diagnosis, monitoring, and cosmetics. MN geometry shape key parameters that dictate performance therapeutic efficacy, however, traditional fabrication methods, such as molding, may not be able to offer rapid design modifications. In this regard, of MNs using 3D printing technology enables creation complex prototypes with high accuracy offers customizable devices a desired dimension. Moreover, shows great potential producing advanced transdermal delivery systems medical by integrating variety technologies. This review aims demonstrate advantages exploiting new tool microengineer MNs. Various methods introduced, representative manufactured approaches highlighted detail. The development is also included. Finally, clinical translation future perspectives for discussed.

Language: Английский

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