Hypoxia
is
a
major
regulator
of
angiogenesis
and
always
influences
the
release
exosomes
in
various
types
tumors.
The
present
review
aimed
to
assess
role
hypoxia-induced
tumor
biology.
relevant
publications
were
retrieved
from
PubMed
using
keywords
such
as
hypoxia,
exosome,
extracellular
vesicles,
tumor,
cancer,
other
similar
terms.
Recent
studies
have
shown
that
cancer
cells
produce
more
under
hypoxic
conditions
than
do
parental
normoxic
conditions.
secretion
function
could
be
influenced
by
hypoxia
cancer.
Hypoxia-induced
play
critical
roles
angiogenesis,
invasion,
metastasis,
immune
system.
These
findings
provide
new
insights
into
complex
networks
underlying
cellular
genomic
regulation
response
might
novel
specific
targets
for
future
therapies.
Annual Review of Cell and Developmental Biology,
Год журнала:
2014,
Номер
30(1), С. 255 - 289
Опубликована: Авг. 23, 2014
In
the
1980s,
exosomes
were
described
as
vesicles
of
endosomal
origin
secreted
from
reticulocytes.
Interest
increased
around
these
extracellular
vesicles,
they
appeared
to
participate
in
several
cellular
processes.
Exosomes
bear
proteins,
lipids,
and
RNAs,
mediating
intercellular
communication
between
different
cell
types
body,
thus
affecting
normal
pathological
conditions.
Only
recently,
scientists
acknowledged
difficulty
separating
other
which
precludes
a
clear
attribution
particular
function
vesicles.
To
shed
light
into
this
complex
but
expanding
field
science,
review
focuses
on
definition
Their
biogenesis,
their
secretion,
subsequent
fate
are
discussed,
functions
rely
important
Science,
Год журнала:
2016,
Номер
352(6282), С. 175 - 180
Опубликована: Апрель 7, 2016
Metastatic
disease
is
the
leading
cause
of
cancer-related
deaths
and
involves
critical
interactions
between
tumor
cells
microenvironment.
Hypoxia
a
potent
microenvironmental
factor
promoting
metastatic
progression.
Clinically,
hypoxia
expression
hypoxia-inducible
transcription
factors
HIF-1
HIF-2
are
associated
with
increased
distant
metastasis
poor
survival
in
variety
types.
Moreover,
HIF
signaling
malignant
influences
multiple
steps
within
cascade.
Here
we
review
research
focused
on
elucidating
mechanisms
by
which
hypoxic
microenvironment
promotes
These
studies
have
identified
potential
biomarkers
therapeutic
targets
regulated
that
could
be
incorporated
into
strategies
aimed
at
preventing
treating
disease.
Pharmacology & Therapeutics,
Год журнала:
2018,
Номер
188, С. 1 - 11
Опубликована: Фев. 21, 2018
Extracellular
vesicles
(EVs)
are
heterogeneous
multi-signal
messengers
that
support
cancer
growth
and
dissemination
by
mediating
the
tumor-stroma
crosstalk.
Exosomes
a
subtype
of
EVs
originate
from
limiting
membrane
late
endosomes,
as
such
contain
information
linked
to
both
intrinsic
cell
"state"
extracellular
signals
cells
received
their
environment.
Resolving
affecting
exosome
biogenesis,
cargo
sorting
release
will
increase
our
understanding
tumorigenesis.
In
this
review
we
highlight
key
biological
processes
couple
biogenesis
in
cells.
Moreover,
discuss
how
bidirectional
communication
between
tumor
non-malignant
affect
metastatic
behavior.
Breast Cancer Research,
Год журнала:
2016,
Номер
18(1)
Опубликована: Сен. 8, 2016
microRNAs
are
promising
candidate
breast
cancer
biomarkers
due
to
their
cancer-specific
expression
profiles.
However,
efforts
develop
circulating
challenged
by
the
heterogeneity
of
in
blood.
To
overcome
this
challenge,
we
aimed
a
molecular
profile
specifically
secreted
from
cells.
Our
first
step
towards
direction
relates
capturing
and
analyzing
contents
exosomes,
which
small
secretory
vesicles
that
selectively
encapsulate
indicative
cell
origin.
our
knowledge,
exosome
have
not
been
well-evaluated
as
for
diagnosis
or
monitoring.Exosomes
were
collected
conditioned
media
human
lines,
mouse
plasma
patient-derived
orthotopic
xenograft
models
(PDX),
samples.
Exosomes
verified
electron
microscopy,
nanoparticle
tracking
analysis,
western
blot.
Cellular
lines
profiled
next-generation
RNA
sequencing.
Plasma
microRNA
was
analyzed
qRT-PCR
analysis.Small
sequencing
analysis
showed
several
encapsulated
highly
enriched
exosomes.
Importantly,
microRNA,
miR-1246,
detected
at
significantly
higher
levels
exosomes
isolated
PDX
plasma,
indicating
tumor
released
into
circulation
can
serve
cancer.
This
observation
extended
samples
where
miR-1246
miR-21
16
patients
with
compared
healthy
control
subjects.
Receiver
operating
characteristic
curve
indicated
combination
is
better
indicator
than
individual
levels.Our
results
demonstrate
certain
species,
such
elevated
These
findings
indicate
potential
new
strategy
analyze
presence
