Small GTPases,
Journal Year:
2017,
Volume and Issue:
9(1-2), P. 95 - 106
Published: Jan. 31, 2017
In
the
last
two
decades,
extracellular
vesicle-mediated
communication
between
cells
has
become
a
major
field
in
cell
biology.
However,
function
of
vesicles
is
far
from
clear,
especially
due
to
disparity
released
by
cells.
Basically,
one
must
consider
budding
plasma
membrane
(ectosomes)
and
upon
fusion
an
endosomal
multivesicular
compartment
(exosomes).
Moreover,
even
for
exosomes,
we
report
discuss
here
possibility
that
different
routes
regulated
specific
Rab
GTPases
might
produce
exosomes
having
various
biologic
functions.
Annual Review of Cell and Developmental Biology,
Journal Year:
2014,
Volume and Issue:
30(1), P. 255 - 289
Published: Aug. 23, 2014
In
the
1980s,
exosomes
were
described
as
vesicles
of
endosomal
origin
secreted
from
reticulocytes.
Interest
increased
around
these
extracellular
vesicles,
they
appeared
to
participate
in
several
cellular
processes.
Exosomes
bear
proteins,
lipids,
and
RNAs,
mediating
intercellular
communication
between
different
cell
types
body,
thus
affecting
normal
pathological
conditions.
Only
recently,
scientists
acknowledged
difficulty
separating
other
which
precludes
a
clear
attribution
particular
function
vesicles.
To
shed
light
into
this
complex
but
expanding
field
science,
review
focuses
on
definition
Their
biogenesis,
their
secretion,
subsequent
fate
are
discussed,
functions
rely
important
Science,
Journal Year:
2016,
Volume and Issue:
352(6282), P. 175 - 180
Published: April 7, 2016
Metastatic
disease
is
the
leading
cause
of
cancer-related
deaths
and
involves
critical
interactions
between
tumor
cells
microenvironment.
Hypoxia
a
potent
microenvironmental
factor
promoting
metastatic
progression.
Clinically,
hypoxia
expression
hypoxia-inducible
transcription
factors
HIF-1
HIF-2
are
associated
with
increased
distant
metastasis
poor
survival
in
variety
types.
Moreover,
HIF
signaling
malignant
influences
multiple
steps
within
cascade.
Here
we
review
research
focused
on
elucidating
mechanisms
by
which
hypoxic
microenvironment
promotes
These
studies
have
identified
potential
biomarkers
therapeutic
targets
regulated
that
could
be
incorporated
into
strategies
aimed
at
preventing
treating
disease.
Pharmacology & Therapeutics,
Journal Year:
2018,
Volume and Issue:
188, P. 1 - 11
Published: Feb. 21, 2018
Extracellular
vesicles
(EVs)
are
heterogeneous
multi-signal
messengers
that
support
cancer
growth
and
dissemination
by
mediating
the
tumor-stroma
crosstalk.
Exosomes
a
subtype
of
EVs
originate
from
limiting
membrane
late
endosomes,
as
such
contain
information
linked
to
both
intrinsic
cell
"state"
extracellular
signals
cells
received
their
environment.
Resolving
affecting
exosome
biogenesis,
cargo
sorting
release
will
increase
our
understanding
tumorigenesis.
In
this
review
we
highlight
key
biological
processes
couple
biogenesis
in
cells.
Moreover,
discuss
how
bidirectional
communication
between
tumor
non-malignant
affect
metastatic
behavior.
Breast Cancer Research,
Journal Year:
2016,
Volume and Issue:
18(1)
Published: Sept. 8, 2016
microRNAs
are
promising
candidate
breast
cancer
biomarkers
due
to
their
cancer-specific
expression
profiles.
However,
efforts
develop
circulating
challenged
by
the
heterogeneity
of
in
blood.
To
overcome
this
challenge,
we
aimed
a
molecular
profile
specifically
secreted
from
cells.
Our
first
step
towards
direction
relates
capturing
and
analyzing
contents
exosomes,
which
small
secretory
vesicles
that
selectively
encapsulate
indicative
cell
origin.
our
knowledge,
exosome
have
not
been
well-evaluated
as
for
diagnosis
or
monitoring.Exosomes
were
collected
conditioned
media
human
lines,
mouse
plasma
patient-derived
orthotopic
xenograft
models
(PDX),
samples.
Exosomes
verified
electron
microscopy,
nanoparticle
tracking
analysis,
western
blot.
Cellular
lines
profiled
next-generation
RNA
sequencing.
Plasma
microRNA
was
analyzed
qRT-PCR
analysis.Small
sequencing
analysis
showed
several
encapsulated
highly
enriched
exosomes.
Importantly,
microRNA,
miR-1246,
detected
at
significantly
higher
levels
exosomes
isolated
PDX
plasma,
indicating
tumor
released
into
circulation
can
serve
cancer.
This
observation
extended
samples
where
miR-1246
miR-21
16
patients
with
compared
healthy
control
subjects.
Receiver
operating
characteristic
curve
indicated
combination
is
better
indicator
than
individual
levels.Our
results
demonstrate
certain
species,
such
elevated
These
findings
indicate
potential
new
strategy
analyze
presence
