The role of the gut microbiota in schizophrenia: Current and future perspectives

The World Journal of Biological Psychiatry, Год журнала: 2018, Номер 19(8), С. 571 - 585

Опубликована: Янв. 31, 2018

Objectives: Schizophrenia is a poorly understood chronic disease. Its pathophysiology complex, dynamic, and linked to epigenetic mechanisms microbiota involvement. Nowadays, correlating schizophrenia with the environment makes sense owing its multidimensional implications: temporal spatial variability. Microbiota involvement are factors that currently being considered better understand another dimension of schizophrenia.Methods: This review summarises discusses available information, focussing on microbiota, mechanisms, technological approaches aimed at performing exhaustive analyses psychotherapies, establish future perspectives.Results: The connection between developments allows for formulating new objectively oriented towards development alternative psychotherapies may help treat schizophrenia.Conclusions: In this review, gut were as key regulators, revealing potential aetiology schizophrenia. Likewise, continuous advances (e.g. culturomics), microbiota-gut–brain axis generate evidence concept.

Язык: Английский

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Attenuated Notch signaling in schizophrenia and bipolar disorder

Scientific Reports, Год журнала: 2018, Номер 8(1)

Опубликована: Март 28, 2018

Abstract The Notch signaling pathway plays a crucial role in neurodevelopment and adult brain homeostasis. We aimed to further investigate activity bipolar disorder (BD) schizophrenia (SCZ) by conducting analysis. measured plasma levels of ligands (DLL1 DLK1) using enzyme immunoassays large sample patients (SCZ n = 551, BD 246) healthy controls (HC 639). also determined related gene expression microarray analyses from whole blood subsample 338, 241 HC 263). found significantly elevated ligand both SCZ compared HC. Significant findings included increased RFNG KAT2B ( p < 0.001), decreased PSEN1 CREBBP patient groups 0.001). RBPJ was lower vs lithium had higher provide evidence altered HC, suggest that may be disturbed these disorders. Lithium ameliorate aberrant signaling. propose drugs targeting could relevant the treatment psychotic

Язык: Английский

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Does the Gut Microbial Metabolome Really Matter? The Connection between GUT Metabolome and Neurological Disorders

Nutrients, Год журнала: 2022, Номер 14(19), С. 3967 - 3967

Опубликована: Сен. 24, 2022

Herein we gathered updated knowledge regarding the alterations of gut microbiota (dysbiosis) and its correlation with human neurodegenerative brain-related diseases, e.g., Alzheimer’s Parkinson’s. This review underlines importance gut-derived metabolites metabolic status as main players in gut-brain crosstalk their implications on severity neural conditions. Scientific evidence indicates that administration probiotic bacteria exerts beneficial protective effects reduced systemic inflammation, neuroinflammation, inhibited neurodegeneration. The experimental results performed animals, but also clinical trials, show designing a novel microbiota-based dietary supplementation aim to prevent or ease symptoms Parkinson’s diseases other forms dementia

Язык: Английский

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Stress: Influences and Determinants of Psychopathology

Encyclopedia, Год журнала: 2024, Номер 4(2), С. 1026 - 1043

Опубликована: Июнь 20, 2024

The stress response is a natural physiological reaction of the organism, elicited to maintain internal environment and evoke adaptive behaviors, ultimately leading survival. However, at turn century, stress-related disorders gained increasing significance. aim entry explore fundamental question when system changes from beneficial detrimental system, contributing higher risk development and/or diseases. To develop context, here, we different concepts reveal complexities, perspectives, multiple relationships between neurochemistry, cerebral functional network, associated pathologies. According literature, affects nearly every biological through close interactions physiological, nervous, endocrine, immune systems faced with real or perceived threat. Considering today’s challenging times, where people are facing unavoidable adversities in their lives level uncertainty never before seen, this review emphasizes importance understanding potential consequences being unable cope stressful events. Susceptibility resilience have recognition as important areas study. literature presented here enhances our identifies causes various psychopathologies, mental health conditions, disabilities, even mortality that closely linked vulnerability stress. Experimental studies recent decades demonstrated many factors affecting ability stress, including differences individuals due genetic background, epigenetic regulation, gender, early-life experiences. Finally, there an urgent need change paradigm modern lifestyles strategy prevent spread “health epidemic 21st century”, which Therefore, acknowledge approaches enhance resilience, focusing on perception, tolerance, positive lifestyle behaviors.

Язык: Английский

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Class 1 histone deacetylases differentially modulate memory and synaptic genes in a spatial and temporal manner in aged and APP/PS1 mice

Brain Research, Год журнала: 2024, Номер 1837, С. 148951 - 148951

Опубликована: Апрель 18, 2024

Язык: Английский

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