Journal of Psychiatry and Neuroscience,
Journal Year:
2024,
Volume and Issue:
49(1), P. E35 - E44
Published: Feb. 1, 2024
Susceptibility
to
schizophrenia
is
determined
by
interactions
between
genes
and
environment,
possibly
via
epigenetic
mechanisms.
Schizophrenia
has
been
associated
with
a
restrictive
epigenome,
histone
deacetylase
(HDAC)
inhibitors
have
postulated
as
coadjuvant
agents
potentiate
the
efficacy
of
current
antipsychotic
drugs.
We
aimed
evaluate
global
posttranslational
modifications
(HPTMs)
HDAC
expression
activity
in
dorsolateral
prefrontal
cortex
(DLPFC)
individuals
schizophrenia.
Nutrients,
Journal Year:
2022,
Volume and Issue:
14(19), P. 3967 - 3967
Published: Sept. 24, 2022
Herein
we
gathered
updated
knowledge
regarding
the
alterations
of
gut
microbiota
(dysbiosis)
and
its
correlation
with
human
neurodegenerative
brain-related
diseases,
e.g.,
Alzheimer’s
Parkinson’s.
This
review
underlines
importance
gut-derived
metabolites
metabolic
status
as
main
players
in
gut-brain
crosstalk
their
implications
on
severity
neural
conditions.
Scientific
evidence
indicates
that
administration
probiotic
bacteria
exerts
beneficial
protective
effects
reduced
systemic
inflammation,
neuroinflammation,
inhibited
neurodegeneration.
The
experimental
results
performed
animals,
but
also
clinical
trials,
show
designing
a
novel
microbiota-based
dietary
supplementation
aim
to
prevent
or
ease
symptoms
Parkinson’s
diseases
other
forms
dementia
Encyclopedia,
Journal Year:
2024,
Volume and Issue:
4(2), P. 1026 - 1043
Published: June 20, 2024
The
stress
response
is
a
natural
physiological
reaction
of
the
organism,
elicited
to
maintain
internal
environment
and
evoke
adaptive
behaviors,
ultimately
leading
survival.
However,
at
turn
century,
stress-related
disorders
gained
increasing
significance.
aim
entry
explore
fundamental
question
when
system
changes
from
beneficial
detrimental
system,
contributing
higher
risk
development
and/or
diseases.
To
develop
context,
here,
we
different
concepts
reveal
complexities,
perspectives,
multiple
relationships
between
neurochemistry,
cerebral
functional
network,
associated
pathologies.
According
literature,
affects
nearly
every
biological
through
close
interactions
physiological,
nervous,
endocrine,
immune
systems
faced
with
real
or
perceived
threat.
Considering
today’s
challenging
times,
where
people
are
facing
unavoidable
adversities
in
their
lives
level
uncertainty
never
before
seen,
this
review
emphasizes
importance
understanding
potential
consequences
being
unable
cope
stressful
events.
Susceptibility
resilience
have
recognition
as
important
areas
study.
literature
presented
here
enhances
our
identifies
causes
various
psychopathologies,
mental
health
conditions,
disabilities,
even
mortality
that
closely
linked
vulnerability
stress.
Experimental
studies
recent
decades
demonstrated
many
factors
affecting
ability
stress,
including
differences
individuals
due
genetic
background,
epigenetic
regulation,
gender,
early-life
experiences.
Finally,
there
an
urgent
need
change
paradigm
modern
lifestyles
strategy
prevent
spread
“health
epidemic
21st
century”,
which
Therefore,
acknowledge
approaches
enhance
resilience,
focusing
on
perception,
tolerance,
positive
lifestyle
behaviors.
The World Journal of Biological Psychiatry,
Journal Year:
2018,
Volume and Issue:
19(8), P. 571 - 585
Published: Jan. 31, 2018
Objectives:
Schizophrenia
is
a
poorly
understood
chronic
disease.
Its
pathophysiology
complex,
dynamic,
and
linked
to
epigenetic
mechanisms
microbiota
involvement.
Nowadays,
correlating
schizophrenia
with
the
environment
makes
sense
owing
its
multidimensional
implications:
temporal
spatial
variability.
Microbiota
involvement
are
factors
that
currently
being
considered
better
understand
another
dimension
of
schizophrenia.Methods:
This
review
summarises
discusses
available
information,
focussing
on
microbiota,
mechanisms,
technological
approaches
aimed
at
performing
exhaustive
analyses
psychotherapies,
establish
future
perspectives.Results:
The
connection
between
developments
allows
for
formulating
new
objectively
oriented
towards
development
alternative
psychotherapies
may
help
treat
schizophrenia.Conclusions:
In
this
review,
gut
were
as
key
regulators,
revealing
potential
aetiology
schizophrenia.
Likewise,
continuous
advances
(e.g.
culturomics),
microbiota-gut–brain
axis
generate
evidence
concept.
Scientific Reports,
Journal Year:
2018,
Volume and Issue:
8(1)
Published: March 28, 2018
Abstract
The
Notch
signaling
pathway
plays
a
crucial
role
in
neurodevelopment
and
adult
brain
homeostasis.
We
aimed
to
further
investigate
activity
bipolar
disorder
(BD)
schizophrenia
(SCZ)
by
conducting
analysis.
measured
plasma
levels
of
ligands
(DLL1
DLK1)
using
enzyme
immunoassays
large
sample
patients
(SCZ
n
=
551,
BD
246)
healthy
controls
(HC
639).
also
determined
related
gene
expression
microarray
analyses
from
whole
blood
subsample
338,
241
HC
263).
found
significantly
elevated
ligand
both
SCZ
compared
HC.
Significant
findings
included
increased
RFNG
KAT2B
(
p
<
0.001),
decreased
PSEN1
CREBBP
patient
groups
0.001).
RBPJ
was
lower
vs
lithium
had
higher
provide
evidence
altered
HC,
suggest
that
may
be
disturbed
these
disorders.
Lithium
ameliorate
aberrant
signaling.
propose
drugs
targeting
could
relevant
the
treatment
psychotic
Journal of Psychiatry and Neuroscience,
Journal Year:
2024,
Volume and Issue:
49(1), P. E35 - E44
Published: Feb. 1, 2024
Susceptibility
to
schizophrenia
is
determined
by
interactions
between
genes
and
environment,
possibly
via
epigenetic
mechanisms.
Schizophrenia
has
been
associated
with
a
restrictive
epigenome,
histone
deacetylase
(HDAC)
inhibitors
have
postulated
as
coadjuvant
agents
potentiate
the
efficacy
of
current
antipsychotic
drugs.
We
aimed
evaluate
global
posttranslational
modifications
(HPTMs)
HDAC
expression
activity
in
dorsolateral
prefrontal
cortex
(DLPFC)
individuals
schizophrenia.
