Permissive epigenetic regulatory mechanisms at the histone level are enhanced in postmortem dorsolateral prefrontal cortex of individuals with schizophrenia DOI Open Access

Oihane Martínez-Peula,

Benito Morentín, Luís F. Callado

et al.

Journal of Psychiatry and Neuroscience, Journal Year: 2024, Volume and Issue: 49(1), P. E35 - E44

Published: Feb. 1, 2024

Susceptibility to schizophrenia is determined by interactions between genes and environment, possibly via epigenetic mechanisms. Schizophrenia has been associated with a restrictive epigenome, histone deacetylase (HDAC) inhibitors have postulated as coadjuvant agents potentiate the efficacy of current antipsychotic drugs. We aimed evaluate global posttranslational modifications (HPTMs) HDAC expression activity in dorsolateral prefrontal cortex (DLPFC) individuals schizophrenia.

Language: Английский

Does the Gut Microbial Metabolome Really Matter? The Connection between GUT Metabolome and Neurological Disorders DOI Open Access
Małgorzata Anna Marć, Rafał Jastrząb, Jennifer Mytych

et al.

Nutrients, Journal Year: 2022, Volume and Issue: 14(19), P. 3967 - 3967

Published: Sept. 24, 2022

Herein we gathered updated knowledge regarding the alterations of gut microbiota (dysbiosis) and its correlation with human neurodegenerative brain-related diseases, e.g., Alzheimer’s Parkinson’s. This review underlines importance gut-derived metabolites metabolic status as main players in gut-brain crosstalk their implications on severity neural conditions. Scientific evidence indicates that administration probiotic bacteria exerts beneficial protective effects reduced systemic inflammation, neuroinflammation, inhibited neurodegeneration. The experimental results performed animals, but also clinical trials, show designing a novel microbiota-based dietary supplementation aim to prevent or ease symptoms Parkinson’s diseases other forms dementia

Language: Английский

Citations

23

Stress: Influences and Determinants of Psychopathology DOI Creative Commons
Inês Pereira-Figueiredo, Eduardo Henrique de Lima Umeoka

Encyclopedia, Journal Year: 2024, Volume and Issue: 4(2), P. 1026 - 1043

Published: June 20, 2024

The stress response is a natural physiological reaction of the organism, elicited to maintain internal environment and evoke adaptive behaviors, ultimately leading survival. However, at turn century, stress-related disorders gained increasing significance. aim entry explore fundamental question when system changes from beneficial detrimental system, contributing higher risk development and/or diseases. To develop context, here, we different concepts reveal complexities, perspectives, multiple relationships between neurochemistry, cerebral functional network, associated pathologies. According literature, affects nearly every biological through close interactions physiological, nervous, endocrine, immune systems faced with real or perceived threat. Considering today’s challenging times, where people are facing unavoidable adversities in their lives level uncertainty never before seen, this review emphasizes importance understanding potential consequences being unable cope stressful events. Susceptibility resilience have recognition as important areas study. literature presented here enhances our identifies causes various psychopathologies, mental health conditions, disabilities, even mortality that closely linked vulnerability stress. Experimental studies recent decades demonstrated many factors affecting ability stress, including differences individuals due genetic background, epigenetic regulation, gender, early-life experiences. Finally, there an urgent need change paradigm modern lifestyles strategy prevent spread “health epidemic 21st century”, which Therefore, acknowledge approaches enhance resilience, focusing on perception, tolerance, positive lifestyle behaviors.

Language: Английский

Citations

5

The role of the gut microbiota in schizophrenia: Current and future perspectives DOI
Daniela Rodrígues-Amorím, Tania Rivera‐Baltanás, Benito Regueiro

et al.

The World Journal of Biological Psychiatry, Journal Year: 2018, Volume and Issue: 19(8), P. 571 - 585

Published: Jan. 31, 2018

Objectives: Schizophrenia is a poorly understood chronic disease. Its pathophysiology complex, dynamic, and linked to epigenetic mechanisms microbiota involvement. Nowadays, correlating schizophrenia with the environment makes sense owing its multidimensional implications: temporal spatial variability. Microbiota involvement are factors that currently being considered better understand another dimension of schizophrenia.Methods: This review summarises discusses available information, focussing on microbiota, mechanisms, technological approaches aimed at performing exhaustive analyses psychotherapies, establish future perspectives.Results: The connection between developments allows for formulating new objectively oriented towards development alternative psychotherapies may help treat schizophrenia.Conclusions: In this review, gut were as key regulators, revealing potential aetiology schizophrenia. Likewise, continuous advances (e.g. culturomics), microbiota-gut–brain axis generate evidence concept.

Language: Английский

Citations

42

Attenuated Notch signaling in schizophrenia and bipolar disorder DOI Creative Commons
Eva Z. Hoseth,

Florian Krull,

Ingrid Dieset

et al.

Scientific Reports, Journal Year: 2018, Volume and Issue: 8(1)

Published: March 28, 2018

Abstract The Notch signaling pathway plays a crucial role in neurodevelopment and adult brain homeostasis. We aimed to further investigate activity bipolar disorder (BD) schizophrenia (SCZ) by conducting analysis. measured plasma levels of ligands (DLL1 DLK1) using enzyme immunoassays large sample patients (SCZ n = 551, BD 246) healthy controls (HC 639). also determined related gene expression microarray analyses from whole blood subsample 338, 241 HC 263). found significantly elevated ligand both SCZ compared HC. Significant findings included increased RFNG KAT2B ( p < 0.001), decreased PSEN1 CREBBP patient groups 0.001). RBPJ was lower vs lithium had higher provide evidence altered HC, suggest that may be disturbed these disorders. Lithium ameliorate aberrant signaling. propose drugs targeting could relevant the treatment psychotic

Language: Английский

Citations

40

Permissive epigenetic regulatory mechanisms at the histone level are enhanced in postmortem dorsolateral prefrontal cortex of individuals with schizophrenia DOI Open Access

Oihane Martínez-Peula,

Benito Morentín, Luís F. Callado

et al.

Journal of Psychiatry and Neuroscience, Journal Year: 2024, Volume and Issue: 49(1), P. E35 - E44

Published: Feb. 1, 2024

Susceptibility to schizophrenia is determined by interactions between genes and environment, possibly via epigenetic mechanisms. Schizophrenia has been associated with a restrictive epigenome, histone deacetylase (HDAC) inhibitors have postulated as coadjuvant agents potentiate the efficacy of current antipsychotic drugs. We aimed evaluate global posttranslational modifications (HPTMs) HDAC expression activity in dorsolateral prefrontal cortex (DLPFC) individuals schizophrenia.

Language: Английский

Citations

4