Environmental influences on the pace of brain development

Nature reviews. Neuroscience, Год журнала: 2021, Номер 22(6), С. 372 - 384

Опубликована: Апрель 28, 2021

Childhood socio-economic status (SES), a measure of the availability material and social resources, is one strongest predictors lifelong well-being. Here we review evidence that experiences associated with childhood SES affect not only outcome but also pace brain development. We argue higher protracted structural development prolonged trajectory functional network segregation, ultimately leading to more efficient cortical networks in adulthood. hypothesize greater exposure chronic stress accelerates maturation, whereas access novel positive decelerates maturation. discuss impact variation on plasticity learning. provide generative theoretical framework catalyse future basic science translational research environmental influences Evidence suggests can its rate. Tooley, Bassett Mackey this suggest valence frequency early interact influence

Язык: Английский

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Cortical thickness across the lifespan: Data from 17,075 healthy individuals aged 3–90 years

Human Brain Mapping, Год журнала: 2021, Номер 43(1), С. 431 - 451

Опубликована: Фев. 17, 2021

Delineating the association of age and cortical thickness in healthy individuals is critical given with cognition behavior. Previous research has shown that robust estimates between brain morphometry require large-scale studies. In response, we used cross-sectional data from 17,075 aged 3-90 years Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Consortium to infer age-related changes thickness. We fractional polynomial (FP) regression quantify thickness, computed normalized growth centiles using parametric Lambda, Mu, Sigma method. Interindividual variability was estimated meta-analysis one-way analysis variance. For most regions, their highest value observed childhood. Age showed a negative association; slope steeper up third decade life more gradual thereafter; notable exceptions this general pattern were entorhinal, temporopolar, anterior cingulate cortices. largest temporal frontal regions across lifespan. its FP combinations explained 59% variance These results may form basis further investigation on normative deviation significance for behavioral cognitive outcomes.

Язык: Английский

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Nurturing Nature: How Brain Development Is Inherently Social and Emotional, and What This Means for Education

Educational Psychologist, Год журнала: 2019, Номер 54(3), С. 185 - 204

Опубликована: Июль 3, 2019

New advances in neurobiology are revealing that brain development and the learning it enables directly dependent on social-emotional experience. Growing bodies of research reveal importance socially triggered epigenetic contributions to network configuration, with implications for functioning, cognition, motivation, learning. Brain is also impacted by health-related physical developmental factors, such as sleep, toxin exposure, puberty, which turn influence functioning cognition. An appreciation dynamic interdependencies experience, underscores a "whole child" approach education reform leads important insights To facilitate these interdisciplinary conversations, here we conceptualize within framework current evidence fundamental ubiquitous biological constraints affordances undergirding learning–related constructs more broadly. Learning indeed depends how nature nurtured.

Язык: Английский

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The older adult brain is less modular, more integrated, and less efficient at rest: A systematic review of large‐scale resting‐state functional brain networks in aging

Psychophysiology, Год журнала: 2022, Номер 60(1)

Опубликована: Сен. 15, 2022

Abstract The literature on large‐scale resting‐state functional brain networks across the adult lifespan was systematically reviewed. Studies published between 1986 and July 2021 were retrieved from PubMed. After reviewing 2938 records, 144 studies included. Results 11 network measures summarized assessed for certainty of evidence using a modified GRADE method. provides high that older adults display reduced within‐network increased between‐network connectivity. Older also show lower segregation, modularity, efficiency hub function, decreased lateralization posterior to anterior shift at rest. Higher‐order reliably showed age differences, whereas primary sensory motor more variable results. inflection point changes is often third or fourth decade life. Age effects found with moderate within‐ altered patterns speed dynamic Research within‐subject bold variability connectivity glucose uptake low differences but warrants further study. Taken together, these age‐related may contribute cognitive decline seen in adults.

Язык: Английский

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Mapping human brain charts cross-sectionally and longitudinally

Proceedings of the National Academy of Sciences, Год журнала: 2023, Номер 120(20)

Опубликована: Май 8, 2023

Brain scans acquired across large, age-diverse cohorts have facilitated recent progress in establishing normative brain aging charts. Here, we ask the critical question of whether cross-sectional estimates age-related trajectories resemble those directly measured from longitudinal data. We show that changes inferred cross-sectionally mapped charts can substantially underestimate actual longitudinally. further find vary markedly between individuals and are difficult to predict with population-level age trends estimated cross-sectionally. Prediction errors relate modestly neuroimaging confounds lifestyle factors. Our findings provide explicit evidence for importance measurements ascertaining development trajectories.

Язык: Английский

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Identifying modifiable factors and their joint effect on dementia risk in the UK Biobank

Nature Human Behaviour, Год журнала: 2023, Номер 7(7), С. 1185 - 1195

Опубликована: Апрель 6, 2023

Язык: Английский

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Brain clocks capture diversity and disparities in aging and dementia across geographically diverse populations

Nature Medicine, Год журнала: 2024, Номер 30(12), С. 3646 - 3657

Опубликована: Авг. 26, 2024

Abstract Brain clocks, which quantify discrepancies between brain age and chronological age, hold promise for understanding health disease. However, the impact of diversity (including geographical, socioeconomic, sociodemographic, sex neurodegeneration) on brain-age gap is unknown. We analyzed datasets from 5,306 participants across 15 countries (7 Latin American Caribbean (LAC) 8 non-LAC countries). Based higher-order interactions, we developed a deep learning architecture functional magnetic resonance imaging (2,953) electroencephalography (2,353). The comprised healthy controls individuals with mild cognitive impairment, Alzheimer disease behavioral variant frontotemporal dementia. LAC models evidenced older ages (functional imaging: mean directional error = 5.60, root square (r.m.s.e.) 11.91; electroencephalography: 5.34, r.m.s.e. 9.82) associated frontoposterior networks compared models. Structural socioeconomic inequality, pollution disparities were influential predictors increased gaps, especially in ( R ² 0.37, F 0.59, 6.9). An ascending to impairment was found. In LAC, observed larger gaps females control groups respective males. results not explained by variations signal quality, demographics or acquisition methods. These findings provide quantitative framework capturing accelerated aging.

Язык: Английский

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Unequal burdens: How structural socioeconomic inequality shapes brain health in aging and dementia

Neuroscience, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Язык: Английский

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Associations between Neighborhood SES and Functional Brain Network Development

Cerebral Cortex, Год журнала: 2019, Номер 30(1), С. 1 - 19

Опубликована: Март 8, 2019

Higher socioeconomic status (SES) in childhood is associated with increased cognitive abilities, higher academic achievement, and decreased incidence of mental illness later development. Accumulating evidence suggests that these effects may be due to changes brain development induced by environmental factors. While prior work has mapped the associations between neighborhood SES structure, little known about relationship intrinsic neural dynamics. Here, we capitalize upon a large community-based sample (Philadelphia Neurodevelopmental Cohort, ages 8-22 years, n=1012) examine developmental functional network topology as estimated from resting state magnetic resonance imaging data. We quantitatively characterize this using local measure segregation clustering coefficient, find it accounts for greater degree SES-associated variance than meso-scale captured modularity. whole-brain age, high-SES youth displayed faster increases low-SES youth, effect was most pronounced regions limbic, somatomotor, ventral attention systems. The on strongest connections intermediate physical length, consistent decreases connectivity tracked BOLD signal complexity form regional homogeneity. Our findings suggest fundamentally alter patterns inter-regional interactions human manner information processing late adolescence.

Язык: Английский

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The effects of low socioeconomic status on decision-making processes

Current Opinion in Psychology, Год журнала: 2019, Номер 33, С. 183 - 188

Опубликована: Авг. 3, 2019

Язык: Английский

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