Epigenetic Mechanism of 5-HT/NE/DA Triple Reuptake Inhibitor on Adult Depression Susceptibility in Early Stress Mice DOI Creative Commons
Ping Meng, Chunmei Li, Sijin Duan

и другие.

Frontiers in Pharmacology, Год журнала: 2022, Номер 13

Опубликована: Март 17, 2022

Major depressive disorder (MDD) is a chronic, remitting and debilitating disease the etiology of MDD highly complicated that involves genetic environmental interactions. Despite many pharmacotherapeutic options, patients remain poorly treated development effective treatments remains high priority in field. LPM570065 potent 5-hydroxytryptamine (5-HT), norepinephrine (NE) dopamine (DA) triple reuptake inhibitor both preclinical clinical results demonstrate significant efficacy against MDD. This study extends previous findings to examine effects underlying mechanisms on stress vulnerability using "two-hit" mouse model. The model used adult mice had experienced early life maternal separation (MS) for social defeat (SDS) then they were evaluated three behavioral assays: sucrose preference test, tail suspension test forced swimming test. For mechanistic studies, methylation-specific differentially expressed genes hippocampal tissue ventral tegmental area (VTA) analyzed by whole-genome transcriptome analysis along with next-generation bisulfite sequencing analysis, followed RT-PCR pyrophosphate confirm gene expression methylation. significantly reversed depressive-like behaviors Morphologically, increased density dendritic spines CA1 neurons. Hypermethylation downregulation oxytocin receptor (

Язык: Английский

New Insights into the Pivotal Role of the Amygdala in Inflammation-Related Depression and Anxiety Disorder DOI Open Access
Ping Hu, Ying Lü, Bing‐Xing Pan

и другие.

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(19), С. 11076 - 11076

Опубликована: Сен. 21, 2022

Depression and anxiety disorders are the two most prevalent psychiatric diseases that affect hundreds of millions individuals worldwide. Understanding etiology related mechanisms is great importance might yield new therapeutic strategies to treat these effectively. During past decades, a growing number studies have pointed out stress-induced inflammatory response in amygdala, kernel region for processing emotional stimuli, as potentially critical contributor pathophysiology depression disorders. In this review, we first summarized recent progress from both animal human toward understanding causal link between inflammation disorders, with particular emphasis on findings showing effect functional changes neurons at levels ranging molecular signaling, cellular function, synaptic plasticity, neural circuit behavior, well their contributions pathology inflammation-related Finally, concluded by discussing some difficulties surrounding current research propose issues worth future study field.

Язык: Английский

Процитировано

79
Radiopharmaceuticals and their applications in medicine DOI Creative Commons
Siqi Zhang, Xingkai Wang, Xin Gao

и другие.

Signal Transduction and Targeted Therapy, Год журнала: 2025, Номер 10(1)

Опубликована: Янв. 2, 2025

Abstract Radiopharmaceuticals involve the local delivery of radionuclides to targeted lesions for diagnosis and treatment multiple diseases. Radiopharmaceutical therapy, which directly causes systematic irreparable damage cells, has attracted increasing attention in refractory diseases that are not sensitive current therapies. As Food Drug Administration (FDA) approvals [ 177 Lu]Lu-DOTA-TATE, Lu]Lu-PSMA-617 their complementary diagnostic agents, namely, 68 Ga]Ga-DOTA-TATE Ga]Ga-PSMA-11, radiopharmaceutical-based theranostics (radiotheranostics) being increasingly implemented clinical practice oncology, lead a new era radiopharmaceuticals. The generation radiopharmaceuticals utilizes targeting vector achieve accurate avoid off-target deposition, making it possible improve efficiency biosafety tumour therapy. Numerous studies have focused on developing novel broader range disease targets, demonstrating remarkable vivo performance. These include high tumor uptake, prolonged retention time, favorable pharmacokinetic properties align with standards. While radiotheranostics been widely applied applications now expanding neurodegenerative diseases, cardiovascular inflammation. Furthermore, radiotheranostic-empowered precision medicine is revolutionizing cancer paradigm. Diagnostic play pivotal role patient stratification planning, leading improved therapeutic outcomes radionuclide This review offers comprehensive overview evolution radiopharmaceuticals, including both FDA-approved clinically investigated explores mechanisms cell death induced by It emphasizes significance future prospects theranostic-based advancing medicine.

Язык: Английский

Процитировано

16
Tryptophan-rich diet ameliorates chronic unpredictable mild stress induced depression- and anxiety-like behavior in mice: The potential involvement of gut-brain axis DOI
Danna Wang, Jianbin Wu,

Peilin Zhu

и другие.

Food Research International, Год журнала: 2022, Номер 157, С. 111289 - 111289

Опубликована: Апрель 25, 2022

Язык: Английский

Процитировано

62
Plasticity in ventral pallidal cholinergic neuron-derived circuits contributes to comorbid chronic pain-like and depression-like behaviour in male mice DOI Creative Commons

Yawei Ji,

Zi-Lin Shen,

Xue Zhang

и другие.

Nature Communications, Год журнала: 2023, Номер 14(1)

Опубликована: Апрель 17, 2023

Abstract Nucleus- and cell-specific interrogation of individual basal forebrain (BF) cholinergic circuits is crucial for refining targets to treat comorbid chronic pain-like depression-like behaviour. As the ventral pallidum (VP) in BF regulates pain perception emotions, we aim address role VP-derived hyperalgesia behaviour mouse model. In male mice, VP neurons innervate local non-cholinergic modulate downstream basolateral amygdala (BLA) through nicotinic acetylcholine receptors. These are mobilized by stimuli become hyperactive during persistent pain. Acute stimulation VP-BLA projection reduces threshold naïve mice whereas inhibition elevated states. Multi-day repetitive modulation pathway Therefore, implicated

Язык: Английский

Процитировано

29
The role of the hippocampus in the consolidation of emotional memories during sleep DOI Open Access
Éléonore Pronier, Juan Facundo Morici, Gabrielle Girardeau

и другие.

Trends in Neurosciences, Год журнала: 2023, Номер 46(11), С. 912 - 925

Опубликована: Сен. 14, 2023

Язык: Английский

Процитировано

29
Neurobiology of Depression: Chronic Stress Alters the Glutamatergic System in the Brain—Focusing on AMPA Receptor DOI Creative Commons
Ming Tatt Lee, Wei‐Hao Peng, Hung‐Wei Kan

и другие.

Biomedicines, Год журнала: 2022, Номер 10(5), С. 1005 - 1005

Опубликована: Апрель 27, 2022

Major depressive disorder (MDD) is a common neuropsychiatric affecting the mood and mental well-being. Its pathophysiology remains elusive due to complexity heterogeneity of this that affects millions individuals worldwide. Chronic stress frequently cited as one risk factors for MDD. To date, conventional monoaminergic theory (serotonin, norepinephrine, and/or dopamine dysregulation) has received most attention in treatment MDD, all available classes antidepressants target these systems. However, contributions other neurotransmitter systems MDD have been widely reported. Emerging preclinical clinical findings reveal maladaptive glutamatergic neurotransmission might underlie thus revealing its critical role neurobiology therapeutic target. Aiming beyond hypothesis, studies neurobiological mechanisms underlying stress-induced impairment AMPA (a-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid)-glutamatergic brain could provide novel insights development new generation without detrimental side effects. Here, authors reviewed recent literature focusing on AMPA-glutamatergic responses emotional mood-associated regions, including hippocampus, amygdala, prefrontal cortex, nucleus accumbens periaqueductal gray.

Язык: Английский

Процитировано

37
Metabotropic Glutamate Receptor 5 in Amygdala Target Neurons Regulates Susceptibility to Chronic Social Stress DOI
Jeongseop Kim, Shinwoo Kang, Tae-Yong Choi

и другие.

Biological Psychiatry, Год журнала: 2022, Номер 92(2), С. 104 - 115

Опубликована: Янв. 25, 2022

Язык: Английский

Процитировано

34
Chronic stress dysregulates the Hippo/YAP/14-3-3η pathway and induces mitochondrial damage in basolateral amygdala in a mouse model of depression DOI Creative Commons
Yan Zhao, Yulong Chen,

Chi-Hua Guo

и другие.

Theranostics, Год журнала: 2024, Номер 14(9), С. 3653 - 3673

Опубликована: Янв. 1, 2024

: Recent evidence highlights the pivotal role of mitochondrial dysfunction in mood disorders, but mechanism involved remains unclear. We studied whether Hippo/YAP/14-3-3η signaling pathway mediates abnormalities that result onset major depressive disorder (MDD) a mouse model.

Язык: Английский

Процитировано

9
FBXL20 promotes synaptic impairment in depression disorder via degrading vesicle-associated proteins DOI
Wenjing Wang, Ye Li,

Liyan Wang

и другие.

Journal of Affective Disorders, Год журнала: 2024, Номер 349, С. 132 - 144

Опубликована: Янв. 9, 2024

Язык: Английский

Процитировано

7
Quercetin alleviates chronic unpredictable mild stress‐induced depression‐like behavior by inhibiting NMDAR1 with α2δ‐1 in rats DOI Creative Commons
Mingyan Wang, Xin Wei, Yugai Jia

и другие.

CNS Neuroscience & Therapeutics, Год журнала: 2024, Номер 30(4)

Опубликована: Апрель 1, 2024

Abstract Background Depression is a serious mental disorder and the most prevalent cause of disability suicide worldwide. Chronic unpredictable mild stress (CUMS) can lead to significant acceleration depression development. Quercetin (Que) flavonoid compound with wide range pharmacological effects. Recent studies have shown that quercetin improve CUMS‐induced depression‐like behavior, but mechanism its improvement still unclear. α2δ‐1 regulatory subunit voltage‐gated calcium channel, which interact N‐methyl‐D‐aspartate receptor (NMDAR) form complex. Objective In this study, we found Que could inhibit increase NMDAR expression in rat hypothalamus induced by CUMS. pain, chronic hypertension other interacts complex, subsequently affects level NMDAR. Consequently, present study aimed investigate antidepressant effect vivo vitro explore action terms interaction between Methods Rats were randomly exposed two stressors every day for 4 weeks establish CUMS model, then sucrose preference test (SPT), forced swimming (FST), tail suspension (TST), open field (OFT) performed detect behavior rats, so as evaluate whether model was successfully established on rats. Experimental techniques such serum enzyme‐linked immunosorbent assay (ELISA), immunofluorescence, Western blot, co‐immunoprecipitation, well experiments, used mechanisms exerts Results Behavioral ELISA results showed produce reduction excitability hypothalamic–pituitary–adrenal (HPA) axis rats improvements their depressive behavior. co‐immunoprecipitation experiments produced decrease NMDAR1 levels interfered binding. addition, neural regulation PC12 cells knocked out gene further verified. Cellular demonstrated led reversal up‐regulation corticosterone‐injured cells, while had no effects knockout. Conclusions has good significantly caused It inhibiting α2δ‐1, interfering NMDAR, reducing HPA axis.

Язык: Английский

Процитировано

7