Brain region–specific roles of brain-derived neurotrophic factor in social stress–induced depressive-like behavior DOI Creative Commons
Man Yong Han,

Deyang Zeng,

Wei Tan

et al.

Neural Regeneration Research, Journal Year: 2024, Volume and Issue: 20(1), P. 159 - 173

Published: April 3, 2024

Brain-derived neurotrophic factor is a key in stress adaptation and avoidance of social behavioral response. Recent studies have shown that brain-derived expression stressed mice brain region–specific, particularly involving the corticolimbic system, including ventral tegmental area, nucleus accumbens, prefrontal cortex, amygdala, hippocampus. Determining how participates processing different regions will deepen our understanding psychopathology. In this review, we discuss regulation stress-sensitive closely related to pathophysiology depression. We focused on associated molecular pathways neural circuits, with special attention factor–tropomyosin receptor kinase B signaling pathway area–nucleus accumbens dopamine circuit. determined stress-induced alterations levels are likely nature, severity, duration stress, especially above-mentioned system. Therefore, BDNF might be biological indicator regulating stress-related processes various regions.

Language: Английский

New Insights into the Pivotal Role of the Amygdala in Inflammation-Related Depression and Anxiety Disorder DOI Open Access
Ping Hu, Ying Lü, Bing‐Xing Pan

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(19), P. 11076 - 11076

Published: Sept. 21, 2022

Depression and anxiety disorders are the two most prevalent psychiatric diseases that affect hundreds of millions individuals worldwide. Understanding etiology related mechanisms is great importance might yield new therapeutic strategies to treat these effectively. During past decades, a growing number studies have pointed out stress-induced inflammatory response in amygdala, kernel region for processing emotional stimuli, as potentially critical contributor pathophysiology depression disorders. In this review, we first summarized recent progress from both animal human toward understanding causal link between inflammation disorders, with particular emphasis on findings showing effect functional changes neurons at levels ranging molecular signaling, cellular function, synaptic plasticity, neural circuit behavior, well their contributions pathology inflammation-related Finally, concluded by discussing some difficulties surrounding current research propose issues worth future study field.

Language: Английский

Citations

76
Radiopharmaceuticals and their applications in medicine DOI Creative Commons
Siqi Zhang, Xingkai Wang, Xin Gao

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)

Published: Jan. 2, 2025

Abstract Radiopharmaceuticals involve the local delivery of radionuclides to targeted lesions for diagnosis and treatment multiple diseases. Radiopharmaceutical therapy, which directly causes systematic irreparable damage cells, has attracted increasing attention in refractory diseases that are not sensitive current therapies. As Food Drug Administration (FDA) approvals [ 177 Lu]Lu-DOTA-TATE, Lu]Lu-PSMA-617 their complementary diagnostic agents, namely, 68 Ga]Ga-DOTA-TATE Ga]Ga-PSMA-11, radiopharmaceutical-based theranostics (radiotheranostics) being increasingly implemented clinical practice oncology, lead a new era radiopharmaceuticals. The generation radiopharmaceuticals utilizes targeting vector achieve accurate avoid off-target deposition, making it possible improve efficiency biosafety tumour therapy. Numerous studies have focused on developing novel broader range disease targets, demonstrating remarkable vivo performance. These include high tumor uptake, prolonged retention time, favorable pharmacokinetic properties align with standards. While radiotheranostics been widely applied applications now expanding neurodegenerative diseases, cardiovascular inflammation. Furthermore, radiotheranostic-empowered precision medicine is revolutionizing cancer paradigm. Diagnostic play pivotal role patient stratification planning, leading improved therapeutic outcomes radionuclide This review offers comprehensive overview evolution radiopharmaceuticals, including both FDA-approved clinically investigated explores mechanisms cell death induced by It emphasizes significance future prospects theranostic-based advancing medicine.

Language: Английский

Citations

11
Tryptophan-rich diet ameliorates chronic unpredictable mild stress induced depression- and anxiety-like behavior in mice: The potential involvement of gut-brain axis DOI
Danna Wang, Jianbin Wu,

Peilin Zhu

et al.

Food Research International, Journal Year: 2022, Volume and Issue: 157, P. 111289 - 111289

Published: April 25, 2022

Language: Английский

Citations

61
Plasticity in ventral pallidal cholinergic neuron-derived circuits contributes to comorbid chronic pain-like and depression-like behaviour in male mice DOI Creative Commons

Yawei Ji,

Zi-Lin Shen,

Xue Zhang

et al.

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: April 17, 2023

Abstract Nucleus- and cell-specific interrogation of individual basal forebrain (BF) cholinergic circuits is crucial for refining targets to treat comorbid chronic pain-like depression-like behaviour. As the ventral pallidum (VP) in BF regulates pain perception emotions, we aim address role VP-derived hyperalgesia behaviour mouse model. In male mice, VP neurons innervate local non-cholinergic modulate downstream basolateral amygdala (BLA) through nicotinic acetylcholine receptors. These are mobilized by stimuli become hyperactive during persistent pain. Acute stimulation VP-BLA projection reduces threshold naïve mice whereas inhibition elevated states. Multi-day repetitive modulation pathway Therefore, implicated

Language: Английский

Citations

26
The role of the hippocampus in the consolidation of emotional memories during sleep DOI Open Access
Éléonore Pronier, Juan Facundo Morici, Gabrielle Girardeau

et al.

Trends in Neurosciences, Journal Year: 2023, Volume and Issue: 46(11), P. 912 - 925

Published: Sept. 14, 2023

Language: Английский

Citations

25
Hyperpolarization-activated channel 1 modulates resilience and susceptibility to social avoidance induced by witnessing social defeat stress DOI Creative Commons
Jiwon Kim,

S Michael,

Kritika Pokharel

et al.

Biological Psychiatry, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Physical social defeat stress models are widely used to study chronic stress. In contrast, witnessing defeat, observing aggression without direct involvement, is less studied but has growing relevance disorders such as post-traumatic disorder (PTSD). The role of hyperpolarization-activated cation channel 1 (HCN1) in responses unclear, and the effects prolonged exposure (PE) therapy, commonly PTSD treatment, have not been tested this context. Male mice were either subjected physical or Behavioral assessments included measures avoidance, reactivity, fear memory, spatial working memory. Neuronal excitability, h current (Ih), synaptic transmission dorsal hippocampal CA1 neurons measured using whole-cell patch-clamp recordings. Conditional overexpression deletion HCN1 was employed further examine its role. Witnessing-defeated underwent 12 days PE treatment. Mice that witnessed exhibited behavioral impairments like physically defeated mice, showing changes behavior, responses. These linked increased expression, elevated Ih, reduced neuronal excitability. Overexpression induced susceptibility-like behaviors, while promoted resilience-like behaviors. Impaired AMPA receptor at distal dendrites witness-susceptible replicated by reversed ZD7288, an HCN blocker. PE-resistant displayed PE-responsive normal-like channels play a key regulating contribute resilience susceptibility following defeat.

Language: Английский

Citations

1
Neurobiology of Depression: Chronic Stress Alters the Glutamatergic System in the Brain—Focusing on AMPA Receptor DOI Creative Commons
Ming Tatt Lee, Wei‐Hao Peng, Hung‐Wei Kan

et al.

Biomedicines, Journal Year: 2022, Volume and Issue: 10(5), P. 1005 - 1005

Published: April 27, 2022

Major depressive disorder (MDD) is a common neuropsychiatric affecting the mood and mental well-being. Its pathophysiology remains elusive due to complexity heterogeneity of this that affects millions individuals worldwide. Chronic stress frequently cited as one risk factors for MDD. To date, conventional monoaminergic theory (serotonin, norepinephrine, and/or dopamine dysregulation) has received most attention in treatment MDD, all available classes antidepressants target these systems. However, contributions other neurotransmitter systems MDD have been widely reported. Emerging preclinical clinical findings reveal maladaptive glutamatergic neurotransmission might underlie thus revealing its critical role neurobiology therapeutic target. Aiming beyond hypothesis, studies neurobiological mechanisms underlying stress-induced impairment AMPA (a-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid)-glutamatergic brain could provide novel insights development new generation without detrimental side effects. Here, authors reviewed recent literature focusing on AMPA-glutamatergic responses emotional mood-associated regions, including hippocampus, amygdala, prefrontal cortex, nucleus accumbens periaqueductal gray.

Language: Английский

Citations

36
Metabotropic Glutamate Receptor 5 in Amygdala Target Neurons Regulates Susceptibility to Chronic Social Stress DOI
Jeongseop Kim, Shinwoo Kang, Tae-Yong Choi

et al.

Biological Psychiatry, Journal Year: 2022, Volume and Issue: 92(2), P. 104 - 115

Published: Jan. 25, 2022

Language: Английский

Citations

33
Potentiated GABAergic neuronal activities in the basolateral amygdala alleviate stress‐induced depressive behaviors DOI Creative Commons
Muhammad Asim, Huajie Wang, Xi Chen

et al.

CNS Neuroscience & Therapeutics, Journal Year: 2023, Volume and Issue: 30(3)

Published: Sept. 16, 2023

Major depressive disorder is a severe psychiatric that afflicts ~17% of the world population. Neuroimaging investigations depressed patients have consistently reported dysfunction basolateral amygdala in pathophysiology depression. However, how BLA and related circuits are implicated pathogenesis depression poorly understood.

Language: Английский

Citations

17
FBXL20 promotes synaptic impairment in depression disorder via degrading vesicle-associated proteins DOI
Wenjing Wang, Ye Li,

Liyan Wang

et al.

Journal of Affective Disorders, Journal Year: 2024, Volume and Issue: 349, P. 132 - 144

Published: Jan. 9, 2024

Language: Английский

Citations

7