Inflammation and emotion regulation: a narrative review of evidence and mechanisms in emotion dysregulation disorders

Neuronal Signaling, Год журнала: 2023, Номер 7(4)

Опубликована: Окт. 27, 2023

Abstract Emotion dysregulation (ED) describes a difficulty with the modulation of which emotions are felt, as well when and how these experienced or expressed. It is focal overarching symptom in many severe prevalent neuropsychiatric diseases, including bipolar disorders (BD), attention deficit/hyperactivity disorder (ADHD), borderline personality (BPD). In all disorders, ED can manifest through symptoms depression, anxiety, affective lability. Considering symptomatic similarities between BD, ADHD, BPD, transdiagnostic approach promising lens investigation. Mounting evidence supports role peripheral inflammatory markers stress multifactorial aetiology physiopathology BPD. Of note, neural circuits that regulate appear particularly vulnerable to insults inflammation, impact neuroimmune milieu central nervous system. Thus far, few studies have examined link inflammation To our knowledge, no specific work has provided critical comparison results from disorders. fill this gap literature, we review known associations mechanisms linking general, clinically, BD. Our narrative begins an examination routes followed by discussion disorder-specific accounting for methodological limitations relevant confounding factors. Finally, critically discuss both correspondences discrepancies comment on potential vulnerability therapeutic interventions.

Язык: Английский

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Propofol anesthesia destabilizes neural dynamics across cortex

Neuron, Год журнала: 2024, Номер 112(16), С. 2799 - 2813.e9

Опубликована: Июль 15, 2024

Every day, hundreds of thousands people undergo general anesthesia. One hypothesis is that anesthesia disrupts dynamic stability-the ability the brain to balance excitability with need be stable and controllable. To test this hypothesis, we developed a method for quantifying changes in population-level stability complex systems: delayed linear analysis estimation (DeLASE). Propofol was used transition animals between awake state anesthetized unconsciousness. DeLASE applied macaque cortex local field potentials (LFPs). We found neural dynamics were more unstable unconsciousness compared state. Cortical trajectories mirrored predictions from destabilized systems. mimicked effect propofol simulated networks by increasing inhibitory tone. This turn networks, as observed data. Our results suggest dynamical required consciousness.

Язык: Английский

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Transcranial focused ultrasound to the posterior cingulate cortex modulates default mode network and subjective experience: an fMRI pilot study

Frontiers in Human Neuroscience, Год журнала: 2024, Номер 18

Опубликована: Июнь 4, 2024

Background Transcranial focused ultrasound (TFUS) is an emerging neuromodulation tool for temporarily altering brain activity and probing network functioning. The effects of TFUS on the default mode (DMN) are unknown. Objective study examined transcranial functional connectivity (DMN), specifically by targeting posterior cingulate cortex (PCC). Additionally, we investigated subjective mood, mindfulness, self-related processing. Methods employed a randomized, single-blind design involving 30 healthy subjects. Participants were randomly assigned to either active group or sham group. Resting-state magnetic resonance imaging (rs-fMRI) scans conducted before after application. To measure effects, Toronto Mindfulness Scale, Visual Analog Mood Amsterdam Resting State Questionnaire administered at baseline min sonication. Self Scale unstructured interview also Results exhibited significant reductions in along midline DMN, while showed no changes. demonstrated increased state reduced Global Vigor, temporary alterations sense ego, time, recollection memories. increase too, with other effects. Conclusions targeted PCC can alter DMN cause changes experience. These findings support potential serve both as research therapeutic intervention.

Язык: Английский

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Obstructive sleep apnea and attention deficits: A systematic review of magnetic resonance imaging biomarkers and neuropsychological assessments

Brain and Behavior, Год журнала: 2023, Номер 13(11)

Опубликована: Сен. 24, 2023

Obstructive sleep apnea (OSA) is a common disorder that causes intermittent hypoxia and fragmentation, leading to attention impairment other cognitive deficits. Magnetic resonance imaging (MRI) powerful modality can reveal the structural functional brain alterations associated with in OSA patients. The objective of this systematic review identify synthesize evidence on MRI biomarkers neuropsychological assessments deficits patients.We searched Scopus PubMed databases for studies used measure related alteration patients reported qualitative quantitative data association between outcomes. We also included found an findings deficits.We 19 met our inclusion criteria extracted relevant from each study. categorized into three groups based domain they used: diffusion tensor findings, functional, perfusion, metabolic assessment findings.We structural, multiple regions networks are involved processing. Treatment continuous positive airway pressure partially reverse some changes improve function domains studies. This suggests techniques be useful tools monitoring progression response treatment

Язык: Английский

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Altered Structural Connectivity and Functional Brain Dynamics in Individuals With Heavy Alcohol Use Elucidated via Network Control Theory

Biological Psychiatry Cognitive Neuroscience and Neuroimaging, Год журнала: 2024, Номер 9(10), С. 1010 - 1018

Опубликована: Июнь 3, 2024

Язык: Английский

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Unveiling the dynamic effects of major depressive disorder and its rTMS interventions through energy landscape analysis

Frontiers in Neuroscience, Год журнала: 2025, Номер 19

Опубликована: Март 5, 2025

Brain dynamics offer a more direct insight into brain function than network structure, providing profound understanding of dysregulation and control mechanisms within intricate systems. This study investigates the functional networks in major depressive disorder (MDD) patients to decipher underlying dysfunction during depression assess impact repetitive transcranial magnetic stimulation (rTMS) intervention. We employed energy landscape analysis resonance imaging (fMRI) data examine MDD patients. The focused on key dynamical indicators default mode (DMN), salience (SN), central execution (CEN). effects rTMS intervention these were also evaluated. Our findings revealed notable alterations pDMN, vDMN, aSN, suggesting their potential as diagnostic therapeutic markers. Particularly striking was altered activity observed dDMN group, indicative patterns associated with rumination. Notably, partially reverses identified alterations. results shed light intrinsic from dynamic standpoint highlight provide promising analytical markers for diagnosis treatment MDD. Future studies should further explore clinical applications comprehensive

Язык: Английский

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Network control energy reductions under DMT relate to serotonin receptors, signal diversity, and subjective experience

Communications Biology, Год журнала: 2025, Номер 8(1)

Опубликована: Апрель 18, 2025

Abstract Psychedelics offer a profound window into the human brain through their robust effects on perception, subjective experience, and activity patterns. The serotonergic psychedelic N,N-dimethyltryptamine (DMT) induces profoundly immersive altered state of consciousness lasting under 20 min, allowing entire experience to be captured during single functional magnetic resonance imaging (fMRI) scan. Using network control theory, we map energy trajectories 14 individuals undergoing fMRI DMT placebo. We find that global is reduced after injection compared Longitudinal correlate with longitudinal electroencephalography (EEG) signal diversity (a measure entropy) drug intensity ratings. At regional level, spatial patterns DMT’s these metrics serotonin 2a receptor density from positron emission tomography (PET) data. distribution pharmacokinetic information, recapitulate trajectories, demonstrating models can predict pharmacological dynamics.

Язык: Английский

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Time-resolved network control analysis links reduced control energy under DMT with the serotonin 2a receptor, signal diversity, and subjective experience

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Май 12, 2023

Psychedelics offer a profound window into the functioning of human brain and mind through their robust acute effects on perception, subjective experience, activity patterns. In recent work using receptor-informed network control theory framework, we demonstrated that serotonergic psychedelics lysergic acid diethylamide (LSD) psilocybin flatten brain's energy landscape in manner covaries with more dynamic entropic activity. Contrary to LSD psilocybin, whose last for hours, psychedelic N,N-dimethyltryptamine (DMT) rapidly induces profoundly immersive altered state consciousness lasting less than 20 minutes, allowing entirety drug experience be captured during single resting-state fMRI scan. Using theory, which quantifies amount input necessary drive transitions between functional states, integrate structure function map trajectories 14 individuals undergoing DMT placebo. Consistent previous work, find global is reduced following injection compared We additionally show longitudinal correlate EEG signal diversity (a measure entropy) ratings intensity. interrogate these same relationships regional level spatial patterns DMT's metrics are correlated serotonin 2a receptor density (obtained from separately acquired PET data). distribution pharmacokinetic information, were able successfully recapitulate trajectories, demonstrating proof-of-concept use models predicting pharmacological intervention dynamics.

Язык: Английский

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Towards customer-centric sustainability: how mindful advertising influences mindful consumption behaviour

Journal of Indian Business Research, Год журнала: 2024, Номер 16(1), С. 119 - 133

Опубликована: Фев. 21, 2024

Purpose Though there is consensus that mindfulness induces mindful consumption (MC), empirical testing needed to uncover the mechanism underlying temperance behaviour in MC model proposed by Sheth et al. (2011). The role of advertising influencing needs deeper investigation. purpose this research paper bridge gap. Design/methodology/approach relationship between and was investigated using an online simulation. Mindful Patagonia, with a message buy less yet demand organic, fair-trade recycled products, introduced as moderator experimental group one. second exposed aspirational advertisement Tommy Hilfiger, symbolic consumption-driving communication. Findings Not buying any brands uppermost preference participants followed which used advertisement. Hilfiger distant third despite A predictive remained elusive. Practical implications Consumer purchase decisions favouring mindfully advertised Patagonia make strong business case for nurturing mindset promoting behaviour. customer-centric sustainability strategy caring people planet beforehand should take precedence over corporate social responsibility usually afterthought. Originality/value Measuring MC, two constructs combined one design, simulation built around real-life marketing communication distinguishes paper.

Язык: Английский

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Psychological distance intervention reminders reduce alcohol consumption frequency in daily life

Scientific Reports, Год журнала: 2023, Номер 13(1)

Опубликована: Июль 25, 2023

Abstract Modifying behaviors, such as alcohol consumption, is difficult. Creating psychological distance between unhealthy triggers and one’s present experience can encourage change. Using two multisite, randomized experiments, we examine whether theory-driven strategies to create distance—mindfulness perspective-taking—can change drinking behaviors among young adults without dependence via a 28-day smartphone intervention (Study 1, N = 108 participants, 5492 observations; Study 2, 218 9994 observations). 2 presents close replication with fully remote delivery during the COVID-19 pandemic. During weeks when they received twice-a-day reminders, individuals in distancing interventions reported less frequently than on control weeks—directionally significantly 2. Intervention reminders reduced frequency but did not impact amount. We find that smartphone-based mindfulness perspective-taking interventions, aimed distance, behavior. This approach requires repeated which be delivered smartphones.

Язык: Английский

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