Global emerging Omicron variant of SARS-CoV-2: Impacts, challenges and strategies

Journal of Infection and Public Health, Год журнала: 2022, Номер 16(1), С. 4 - 14

Опубликована: Ноя. 19, 2022

Newly emerging variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are continuously posing high global public health concerns and panic resulting in waves disease 2019 (COVID-19) pandemic. Depending on the extent genomic variations, mutations adaptation, few gain ability to spread quickly across many countries, acquire higher virulency cause disease, morbidity mortality. These have been implicated lessening efficacy current COVID-19 vaccines immunotherapies break-through viral infections vaccinated individuals recovered patients. Altogether, these could hinder protective herd immunity be achieved through ongoing progressive vaccination. Currently, only variant interest SARS-CoV-2 is Omicron that was first identified South Africa. In this review, we present overview with a special focus variant, its lineages hybrid variants. We discuss hypotheses origin, genetic change underlying molecular mechanism behind transmissibility immune escape variant. Major related including available immunotherapeutics vaccines, transmissibility, severity, mortality discussed. last part, challenges strategies counter amid pandemic presented.

Язык: Английский

---

Prevalence of covid-19 among patients with chronic obstructive pulmonary disease and tuberculosis

Annals of Medicine, Год журнала: 2023, Номер 55(1), С. 285 - 291

Опубликована: Янв. 3, 2023

The exhaustive information about non-communicable diseases associated with COVID-19 and severe acute respiratory syndrome corona virus-2 (SARS-CoV-2) are getting easier to find in the literature. However, there is a lack of knowledge regarding tuberculosis (TB) chronic obstructed pulmonary disease (COPD), numerous infections patients.Priority placed on determining patient's prognosis based presence or absence TB COPD. Additionally, comparison made between risk death likelihood recovery terms time patients who have either COPD TB.At DHQ Hospital Muzaffargarh, Punjab, Pakistan, 498 were studied retrospectively. duration study started February 2022 concluded August 2022. Kaplan-Meier curves described time-to-death time-to-recovery stratified by status. Wilcoxon test compared survival rates people two matched paired groups their status differences standard living.The was 1.476 times higher than those without (95% CI: 0.949-2.295). 0.677 lower 0.436-1.054). Similarly, had significantly shorter (p=.001) longer (p=.001).According findings, most significant contributor an increased morbidity mortality COVID-19.KEY MESSAGESSARS-Cov-19 new challenge for universe prevention treatment obstructive disease, among other diseases.Propensity score matching control potential biases.Compared hospitalized (TB COPD) equivalently rate.

Язык: Английский

---

Variant-specific deleterious mutations in the SARS-CoV-2 genome reveal immune responses and potentials for prophylactic vaccine development

Frontiers in Pharmacology, Год журнала: 2023, Номер 14

Опубликована: Фев. 7, 2023

Introduction: Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, has had a disastrous effect worldwide during the previous three years due to widespread infections with SARS-CoV-2 and its emerging variations. More than 674 million confirmed cases over 6.7 deaths have been attributed successive waves of as 29th January 2023. Similar other RNA viruses, is more susceptible genetic evolution spontaneous mutations time, resulting in continual emergence variants distinct characteristics. Spontaneous increase transmissibility, virulence, severity diminish efficacy therapeutics vaccines, vaccine-breakthrough re-infection, leading high mortality morbidity rates. Materials methods: In this study, we evaluated 10,531 whole genome sequences all reported globally through computational approach assess spread genome. The available data sources NextCladeCLI 2.3.0 (https://clades.nextstrain.org/) NextStrain (https://nextstrain.org/) were searched for tracking mutations, analysed using PROVEAN, Polyphen-2, Predict SNP mutational analysis tools validated Machine Learning models. Result: Compared Wuhan-Hu-1 reference strain NC 045512.2, genome-wide annotations showed 16,954 We determined that Omicron variant 6,307 (retrieved sequence:1947), including 67.8% unique any study. spike protein harboured 876 443 deleterious mutations. Among these 187 common 256 non-synonymous contrast, after analysing 1,884 Delta variant, discovered 4,468 which 66% unique, not previously variants. Mutations affecting proteins are mostly found RBD regions Omicron, whereas most drawn focus on amino acid ranging from 911 924 context epitope prediction (B cell & T cell) stability impact protruding transmissible. Discussion: pathogenesis could be prevented if persistent immunosuppressive can targeted vaccination or small-molecule inhibitor designing. Thus, our findings will help researchers monitor track continuously evolving nature strains, associated variants, their implications developing effective control prophylaxis strategies.

Язык: Английский

---

Changing epidemiology of COVID-19: potential future impact on vaccines and vaccination strategies

Expert Review of Vaccines, Год журнала: 2024, Номер 23(1), С. 510 - 522

Опубликована: Апрель 24, 2024

COVID-19 was an unprecedented challenge worldwide; however, disease epidemiology has evolved, and no longer constitutes a public health emergency of international concern. Nonetheless, remains global threat uncertainties remain, including definition the end pandemic transition to endemicity, understanding true rates SARS-CoV-2 infection/transmission.

Язык: Английский

---

Lessons from the COVID-19 Pandemic: Promoting Vaccination and Public Health Resilience, a Narrative Review

Vaccines, Год журнала: 2024, Номер 12(8), С. 891 - 891

Опубликована: Авг. 7, 2024

The COVID-19 pandemic has underscored the critical importance of adaptable and resilient public health systems capable rapid response to emerging crises. This paper synthesizes lessons learned from vaccination campaign explores strategies enhance vaccine uptake in post-pandemic era. Key challenges identified include logistical, economic, sociocultural, policy dimensions that impact efforts, particularly low-resource settings. analysis highlights need for supply chains, effective communication, community engagement, equitable access healthcare resources. development deployment mRNA vaccines exemplify potential innovative technologies, though trust acceptance remain crucial. Strategies such as partnerships with local leaders, tailored messaging, integration digital tools are essential combating hesitancy. By applying these insights, future campaigns can be more efficient, equitable, resilient, ultimately improving outcomes globally. aims inform practice, ensuring evidence based context specific, thus better preparing challenges.

Язык: Английский

---

Twitter-Based Sentiment Analysis and Topic Modeling of Social Media Posts Using Natural Language Processing, to Understand People’s Perspectives Regarding COVID-19 Booster Vaccine Shots in India: Crucial to Expanding Vaccination Coverage

Vaccines, Год журнала: 2022, Номер 10(11), С. 1929 - 1929

Опубликована: Ноя. 15, 2022

This study analyzed perceptions of Indians regarding COVID-19 booster dose vaccines using natural language processing techniques, particularly, sentiment analysis and topic modeling. We tweets generated by Indian citizens for this study. In late July 2022, the government hastened process vaccinations. Understanding emotions concerns health policy being implemented will assist government, officials, policymakers implement efficiently so that desired results can be achieved. Seventy-six thousand nine hundred seventy-nine were used The revealed out those 76,979 tweets, more than half (n = 40,719 (52.8%) had negative sentiments, 24,242 (31.5%) neutral 12,018 (15.6%) positive sentiments. Social media posts on doses have focused feelings younger people do not need vaccinations are unhealthy.

Язык: Английский

---

Ghosts of the past: Elemental composition, biosynthesis reactions and thermodynamic properties of Zeta P.2, Eta B.1.525, Theta P.3, Kappa B.1.617.1, Iota B.1.526, Lambda C.37 and Mu B.1.621 variants of SARS-CoV-2

Microbial Risk Analysis, Год журнала: 2023, Номер 24, С. 100263 - 100263

Опубликована: Май 20, 2023

Язык: Английский

---

The End or a New Era of Development of SARS-CoV-2 Virus: Genetic Variants Responsible for Severe COVID-19 and Clinical Efficacy of the Most Commonly Used Vaccines in Clinical Practice

Vaccines, Год журнала: 2023, Номер 11(7), С. 1181 - 1181

Опубликована: Июнь 30, 2023

Although the chief of World Health Organization (WHO) has declared end coronavirus disease 2019 (COVID-19) as a global health emergency, is still threat. To be able to manage such pandemics in future, it necessary develop proper strategies and opportunities protect human life. The data on SARS-CoV-2 virus must continuously analyzed, possibilities mutation emergence new, more infectious variants anticipated, well options using different preventive therapeutic techniques. This because fast development severe acute 2 syndrome (SARS-CoV-2) concern have posed significant problem for COVID-19 pandemic control presently available vaccinations. review summarizes that are responsible clinical efficacy most commonly used vaccines practice. consequences after (long COVID or post-COVID conditions) continue subject studies research, affect social economic life worldwide.

Язык: Английский

---

Synthesis, molecular docking, and binding Gibbs free energy calculation of β-nitrostyrene derivatives: Potential inhibitors of SARS-CoV-2 3CL protease

Journal of Molecular Structure, Год журнала: 2023, Номер 1284, С. 135409 - 135409

Опубликована: Март 23, 2023

Язык: Английский

---

CT-derived vertebral bone mineral density is a useful biomarker to predict COVID-19 outcome

Bone, Год журнала: 2024, Номер 184, С. 117095 - 117095

Опубликована: Апрель 8, 2024

Язык: Английский

---