International Journal of Environmental Health Research,
Год журнала:
2025,
Номер
unknown, С. 1 - 11
Опубликована: Фев. 13, 2025
The
global
consumption
of
bottled
water
has
surged,
particularly
where
safe
drinking
is
scarce
Plastic
bottles
may
leachharmful
Endocrine
Disrupting
Chemicals
(EDCs),
including
bisphenol-A
(BPA)
and
phthalate
esters
(PAEs),
into
the
water.
This
study
analyzes
BPA
six
PAEs
in
from
various
brands
Central
India,
utilizing
gas
chromatography-mass
spectrometry
(GC-MS).
A
total
39
samples
13
were
analyzed.
results
show
detectable
levels
(35.397
µg/L
to
273.513
µg/L)
(ND
1147.340
µg/L),
with
significant
concentrations
di-n-butyl
(DBP),
bis(2-ethylhexyl)
(DEHP),
BPA,
posing
potential
health
risks.
risk
assessment
based
on
hazard
quotients
(HQ)
indicated
that
DEHP
exceeded
exposure
thresholds
for
non-carcinogenic
anti-androgenic
Additionally,
exhibited
a
carcinogenic
risk.
These
findings
emphasize
need
stricter
regulations
continuous
monitoring
mitigate
risks
associated
EDC
Journal of Clinical Medicine,
Год журнала:
2023,
Номер
12(4), С. 1454 - 1454
Опубликована: Фев. 11, 2023
Polycystic
ovary
syndrome
(PCOS)
is
a
complex
endocrine
and
metabolic
disorder,
typically
characterized
by
anovulation,
infertility,
obesity,
insulin
resistance,
polycystic
ovaries.
Lifestyle
or
diet,
environmental
pollutants,
genetics,
gut
dysbiosis,
neuroendocrine
alterations,
obesity
are
among
the
risk
factors
that
predispose
females
to
PCOS.
These
might
contribute
upsurging
causing
hyperinsulinemia,
oxidative
stress,
hyperandrogenism,
impaired
folliculogenesis,
irregular
menstrual
cycles.
Dysbiosis
of
microbiota
may
play
pathogenic
role
in
development
The
restoration
probiotics,
prebiotics,
fecal
transplant
(FMT)
serve
as
an
innovative,
efficient,
noninvasive
way
prevent
mitigate
This
review
deliberates
on
variety
potentially
involved
etiology,
prevalence,
modulation
PCOS,
addition
plausible
therapeutic
interventions,
including
miRNA
therapy
eubiosis
microbiota,
help
treat
manage
Cancers,
Год журнала:
2023,
Номер
15(6), С. 1913 - 1913
Опубликована: Март 22, 2023
The
complexity
and
variety
of
gut
microbiomes
within
among
individuals
have
been
extensively
studied
in
recent
years
connection
to
human
health
diseases.
Our
growing
understanding
the
bidirectional
communication
between
metabolic
diseases
microbiome
has
also
highlighted
significance
dysbiosis
genesis
development
obesity-related
cancers.
Therefore,
it
is
crucial
comprehend
possible
role
microbiota
crosstalk
obesity
colorectal
cancer
(CRC).
Through
induction
microbial
dysbiosis,
epithelial
barrier
impairment,
metabolomic
dysregulation,
chronic
inflammation,
or
dysregulation
energy
harvesting,
may
promote
tumors.
It
well
known
that
strategies
for
prevention
treatment
are
most
effective
when
combined
with
a
healthy
diet,
physical
activity,
active
lifestyle
choices.
Recent
studies
suggest
an
improved
complex
linkages
various
cancers
as
can
potentially
improve
treatments
overall
outcomes.
In
this
context,
we
herein
review
summarize
clinical
experimental
evidence
supporting
functional
pathogenesis
progression
CRC
concerning
its
correlates,
which
pave
way
novel
prognostic
tools
prevention.
Therapeutic
approaches
restoring
homeostasis
conjunction
discussed
herein.
Ecotoxicology and Environmental Safety,
Год журнала:
2023,
Номер
266, С. 115565 - 115565
Опубликована: Окт. 11, 2023
Exposure
to
particulate
matter
(PM)
has
been
associated
with
a
range
of
health
impacts,
including
neurological
abnormalities
that
affect
neurodevelopment,
neuroplasticity,
and
behavior.
Recently,
there
growing
interest
in
investigating
the
possible
relationship
between
PM
exposure
onset
progression
neurodegenerative
diseases,
such
as
Alzheimer's
disease,
Parkinson's
Huntington's
multiple
sclerosis.
However,
precise
mechanism
by
which
affects
neurodegeneration
is
still
unclear,
even
though
several
epidemiological
animal
model
studies
have
provided
mechanistic
insights.
This
article
presents
review
current
research
on
neurotoxicity
its
impact
diseases.
summarizes
findings
from
collected
through
searches
Google
Scholar,
PubMed,
Web
Science,
Scopus.
paper
also
discusses
reported
effects
central
nervous
system
highlights
gaps
future
directions.
The
information
presented
this
may
inform
public
policies
aimed
at
reducing
contribute
development
new
treatments
for
Further
therapeutic
will
be
needed
fully
understand
Environmental Pollution,
Год журнала:
2024,
Номер
348, С. 123732 - 123732
Опубликована: Март 8, 2024
The
gut-brain
axis
is
a
crucial
interface
between
the
central
nervous
system
and
gut
microbiota.
Recent
evidence
shows
that
exposure
to
environmental
contaminants,
such
as
heavy
metals,
can
cause
dysbiosis
in
microbiota,
which
may
affect
communication,
impacting
aspects
of
brain
function
behavior.
This
systematic
review
literature
aims
evaluate
whether
deleterious
effects
on
due
metal
could
be
mediated
by
changes
microbiota
profile.
Animal
studies
involving
metals
comparison
with
control
group
evaluated
neuropsychological
outcomes
and/or
molecular
along
analysis
composition
were
reviewed.
authors
independently
assessed
for
inclusion,
extracted
data
risk
bias
using
protocol
Systematic
Review
Center
Laboratory
Experimentation
(SYRCLE)
preclinical
studies.
A
search
3
databases
yielded
16
eligible
focused
lead
(n
=
10),
cadmium
1),
mercury
3),
manganese
combined
Pb
Mn
1).
animal
species
rats
7),
mice
4),
zebrafish
carp
1)
fruit
fly
Heavy
found
adversely
cognitive
function,
behavior,
neuronal
morphology.
Moreover,
was
associated
abundance
specific
bacterial
phyla,
Firmicutes
Proteobacteria,
play
roles
health.
In
some
studies,
these
alterations
correlated
learning
memory
impairments
mood
disorders.
interplay
suggests
induce
direct
indirect
through
contributing
neurotoxicity
development
However,
small
number
papers
under
makes
it
difficult
draw
definitive
conclusions.
Further
research
warranted
unravel
underlying
mechanisms
translational
implications
human
Frontiers in Psychiatry,
Год журнала:
2024,
Номер
15
Опубликована: Фев. 9, 2024
Depression
is
considered
a
multifaceted
and
intricate
mental
disorder
of
growing
concern
due
to
its
significant
impact
on
global
health
issues.
The
human
gut
microbiota,
also
known
as
the
“second
brain,”
has
an
important
role
in
CNS
by
regulating
it
through
chemical,
immunological,
hormonal,
neurological
processes.
Various
studies
have
found
bidirectional
link
between
brain
gut,
emphasizing
onset
depression
therapies.
biological
molecular
processes
underlying
microbiota
are
required,
association
may
represent
novel
study.
However,
profound
insights
into
stratification
diversity
still
uncommon.
This
article
investigates
emerging
evidence
bacterial
relationship
brain’s
system
potential
pathogenicity
relevance.
interplay
immune
system,
nervous
neurotransmitter
synthesis,
neuroplasticity
transitions
widely
studied.
consequences
stress,
dietary
fibers,
probiotics,
prebiotics,
antibiotics
GB
axis
being
Multiple
revealed
this
led
development
effective
microbiota-based
drugs
for
both
prevention
treatment.
Therefore,
results
support
hypothesis
that
influences
provide
promising
area
research
improved
knowledge
etiology
disease
future
International Journal of Environmental Research and Public Health,
Год журнала:
2022,
Номер
19(23), С. 15494 - 15494
Опубликована: Ноя. 22, 2022
A
balanced
microbiota
composition
is
requisite
for
normal
physiological
functions
of
the
human
body.
However,
several
environmental
factors
such
as
air
pollutants
may
perturb
composition.
It
noticeable
that
currently
around
99%
world’s
population
breathing
polluted
air.
Air
pollution’s
debilitating
health
impacts
have
been
studied
scrupulously,
including
in
gut
microbiota.
Nevertheless,
impact
on
other
microbiotas
body
less
understood
so
far.
In
present
review,
authors
summarized
and
discussed
recent
studies’
outcomes
related
to
pollution-driven
microbiotas’
dysbiosis
(including
oral,
nasal,
respiratory,
gut,
skin,
thyroid
microbiotas)
its
potential
multi-organ
risks.
Genes,
Год журнала:
2023,
Номер
14(7), С. 1506 - 1506
Опубликована: Июль 24, 2023
Nutrition
and
metabolism
modify
epigenetic
signatures
like
histone
acetylation
DNA
methylation.
Histone
methylation
in
the
central
nervous
system
(CNS)
can
be
altered
by
bioactive
nutrients
gut
microbiome
via
gut-brain
axis,
which
turn
modulate
neuronal
activity
behavior.
Notably,
microbiome,
with
more
than
1000
bacterial
species,
collectively
contains
almost
three
million
functional
genes
whose
products
interact
millions
of
human
marks
30,000
a
dynamic
manner.
However,
genetic
makeup
shapes
composition,
food/nutrient
metabolism,
landscape,
as
well.
Here,
we
first
discuss
effect
changes
microbial
structure
composition
shaping
specific
alterations
brain
their
role
onset
progression
major
mental
disorders.
Afterward,
potential
interactions
among
maternal
diet/environmental
factors,
nutrition,
gastrointestinal
roles
accelerating
or
delaying
severe
illnesses
will
discussed.
We
also
provide
an
overview
association
between
oxidative
stress,
inflammation
through
mechanisms.
Finally,
present
some
underlying
mechanisms
involved
mediating
influence
probiotics
on
health
modifications.
