Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: unknown, P. 106249 - 106249
Published: Oct. 1, 2024
Language: Английский
Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: unknown, P. 106249 - 106249
Published: Oct. 1, 2024
Language: Английский
International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: 670, P. 125186 - 125186
Published: Jan. 8, 2025
The blood-brain barrier (BBB) plays a vital role in protecting the central nervous system (CNS) by preventing entry of harmful pathogens from bloodstream. However, this also presents significant obstacle when it comes to delivering drugs for treatment neurodegenerative diseases and brain cancer. Recent breakthroughs nanotechnology have paved way creation wide range nanoparticles (NPs) that can serve as carriers diagnosis therapy. Regarding their promising properties, organic NPs potential be used effective drug delivery across BBB based on recent advancements. These remarkable ability penetrate using various mechanisms. This review offers comprehensive examination intricate structure distinct properties BBB, emphasizing its crucial function preserving balance regulating transport ions molecules. disruption conditions such stroke, Alzheimer's disease, Parkinson's disease highlights importance developing creative approaches drugs. Through encapsulation therapeutic molecules precise targeting processes vasculature, NP formulations present hopeful strategy improve BBB. We explore changes pathological investigate factors affect successful into brain. In addition, we most systems associated with shown positive results treating ischemic disorders. opens up new possibilities nanotechnology-based therapies cerebral diseases.
Language: Английский
Citations
8Archives of Dermatological Research, Journal Year: 2025, Volume and Issue: 317(1)
Published: Jan. 31, 2025
Language: Английский
Citations
5European Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: 287, P. 117357 - 117357
Published: Feb. 5, 2025
Language: Английский
Citations
5Ecological Genetics and Genomics, Journal Year: 2025, Volume and Issue: 34, P. 100324 - 100324
Published: Jan. 5, 2025
Language: Английский
Citations
1Clinica Chimica Acta, Journal Year: 2025, Volume and Issue: 569, P. 120179 - 120179
Published: Feb. 1, 2025
Language: Английский
Citations
1International Communications in Heat and Mass Transfer, Journal Year: 2025, Volume and Issue: 164, P. 108895 - 108895
Published: March 29, 2025
Language: Английский
Citations
1Life Sciences, Journal Year: 2024, Volume and Issue: unknown, P. 123120 - 123120
Published: Oct. 1, 2024
Language: Английский
Citations
8Biotechnology Notes, Journal Year: 2025, Volume and Issue: 6, P. 59 - 66
Published: Jan. 1, 2025
Recently, a unique behavior of T7 RNA polymerase has expanded its functionality as biosensing platform. Various biosensors utilizing polymerase, combined with fluorescent aptamers, electrochemical probes, or CRISPR/Cas systems, have been developed to detect analytes, including nucleic acids and non-nucleic acid target, high specificity low detection limits. Each approach demonstrates strengths, such real-time monitoring minimal interference, but also presents challenges in stability, cost, reaction optimization. This review provides an overview polymerase's role technology, highlighting potential advance diagnostics molecular diverse fields.
Language: Английский
Citations
0Cancer Cell International, Journal Year: 2025, Volume and Issue: 25(1)
Published: March 26, 2025
Abstract Multiple myeloma (MM) is a hematological malignancy defined by the abnormal proliferation and accumulation of plasma cells (PC) within bone marrow (BM). While multiple impacts bone, it not classified as primary cancer. The microenvironment significantly influences progression its treatment response. Mesenchymal stromal (MSCs) in this environment engage with other components via direct contact secretion soluble factors. This review examines established roles MSCs facets MM pathology, encompassing their pro-inflammatory functions, contributions to tumor epigenetics, effects on immune checkpoint inhibitors (ICIs), influence reprogramming, chemotherapy resistance, senescence. investigates role development MM.
Language: Английский
Citations
0Journal of Molecular Histology, Journal Year: 2025, Volume and Issue: 56(2)
Published: April 1, 2025
Language: Английский
Citations
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