Scientific Reports,
Год журнала:
2023,
Номер
13(1)
Опубликована: Апрель 8, 2023
Abstract
The
potential
of
sponge-derived
chemicals
for
pharmaceutical
applications
remains
largely
unexploited
due
to
limited
available
biomass.
Although
many
have
attempted
culture
marine
sponge
cells
in
vitro
create
a
scalable
production
platform
such
biopharmaceuticals,
these
efforts
been
mostly
unsuccessful.
We
recently
showed
that
Geodia
barretti
could
divide
rapidly
M1
medium.
In
this
study
we
established
the
first
continuous
cell
line,
originating
from
G.
.
cultured
OpM1
medium,
modification
M1,
grew
more
and
higher
density
than
M1.
Cells
reached
1.74
population
doublings
after
30
min,
twofold
already
rapid
growth
rate
0.74
min
maximum
number
increased
5
at
least
98
OpM1.
Subcultured
be
cryopreserved
used
inoculate
new
cultures.
With
results,
overcome
major
obstacle
has
blocked
path
producing
biopharmaceuticals
with
industrial
scale
decades.
Frontiers in Marine Science,
Год журнала:
2021,
Номер
8
Опубликована: Март 16, 2021
Coastal
countries
have
traditionally
relied
on
the
existing
marine
resources
(e.g.,
fishing,
food,
transport,
recreation,
and
tourism)
as
well
tried
to
support
new
economic
endeavors
(ocean
energy,
desalination
for
water
supply,
seabed
mining).
Modern
societies
lifestyle
resulted
in
an
increased
demand
dietary
diversity,
better
health
well-being,
biomedicines,
natural
cosmeceuticals,
environmental
conservation,
sustainable
energy
sources.
These
societal
needs
stimulated
interest
of
researchers
diverse
underexplored
environments
promising
sources
biomolecules
biomass,
they
are
addressed
by
emerging
field
(blue)
biotechnology.
Blue
biotechnology
provides
opportunities
a
wide
range
initiatives
commercial
pharmaceutical,
biomedical,
cosmetic,
nutraceutical,
feed,
agricultural,
related
industries.
This
article
synthesizes
essence,
opportunities,
responsibilities,
challenges
encountered
outlines
attainment
valorization
directly
derived
or
bio-inspired
products
from
organisms.
First,
concept
bioeconomy
is
introduced.
Then,
diversity
bioresources
including
overview
most
prominent
organisms
their
potential
biotechnological
uses
described.
followed
introducing
methodologies
exploration
these
main
use
case
scenarios
food
agronomy,
bioremediation
climate
change,
materials,
healthcare,
well-being
sectors.
The
key
aspects
fields
legislation
funding
provided,
with
emphasis
importance
communication
stakeholder
engagement
at
all
levels
development.
Finally,
vital
overarching
concepts,
such
quadruple
helix
Responsible
Research
Innovation
principle
highlighted
important
follow
within
field.
authors
this
review
collaborating
under
European
Commission-funded
Cooperation
Science
Technology
(COST)
Action
Ocean4Biotech
–
transdisciplinary
networking
platform
focus
study
state
affairs.
Cancer Science,
Год журнала:
2020,
Номер
111(11), С. 4242 - 4256
Опубликована: Сен. 21, 2020
Abstract
Abnormal
activation
of
the
nuclear
factor‐kappa
B
(NF‐κB)
signaling
pathway
is
closely
implicated
in
triple‐negative
breast
cancer
growth,
metastasis,
and
tumor
immune
escape.
In
this
study,
anti‐cancer
effects
icariin,
a
natural
flavonol
glycoside,
toward
cells
underlying
mechanisms
were
investigated.
This
investigation
showed
that
icariin
selectively
inhibited
proliferation
triggered
apoptosis
concentration‐
time‐dependent
manner,
but
exhibited
little
cytotoxicity
normal
cells.
Moreover,
induced
cell
via
mitochondria‐mediated
pathway,
as
indicated
by
upregulated
ratio
Bax/Bcl‐2
reactive
oxygen
species
induction.
Importantly,
impaired
NF‐κB/EMT
evidenced
upregulation
SIRT6,
resulting
inhibition
migration
invasion
Additionally,
oss‐128167,
an
inhibitor
dramatically
attenuated
anti‐migration
anti‐invasion
icariin.
Transcriptomic
analysis
verified
impairment
NF‐κB
led
to
selective
function
Notably,
significant
growth
anti‐pulmonary
metastasis
effect
mouse
model
MDA‐MB‐231
4T1
regulating
immunosuppressive
microenvironment.
Together,
these
results
could
effectively
trigger
inhibit
SIRT6/NF‐κB
suggesting
might
serve
potential
candidate
drug
for
treatment
cancer.
Journal of Natural Products,
Год журнала:
2024,
Номер
87(7), С. 1844 - 1851
Опубликована: Июль 6, 2024
Natural
products
(NPs)
or
their
derivatives
represent
a
large
proportion
of
drugs
that
successfully
progress
through
clinical
trials
to
approval.
This
study
explores
the
presence
NPs
in
both
early-
and
late-stage
drug
discovery
determine
success
rate,
factors
features
natural
contribute
such
success.
As
proxy
for
early
development
stages,
we
analyzed
patent
applications
over
several
decades,
finding
consistent
NP,
NP-derived,
synthetic-compound-based
documents,
with
latter
group
outnumbering
NP
NP-derived
ones
(approximately
77%
vs
23%).
We
next
assessed
trial
data,
where
observed
steady
increase
compounds
from
phases
I
III
(from
approximately
35%
phase
45%
III),
an
inverse
trend
synthetics
65%
55%
III).
Finally,
vitro
silico
toxicity
studies
revealed
were
less
toxic
alternatives
synthetic
counterparts.
These
discoveries
offer
valuable
insights
successful
NP-based
development,
highlighting
potential
benefits
prioritizing
as
starting
points.
Journal of Medicinal Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 6, 2025
Drug
discovery,
a
multifaceted
process
from
compound
identification
to
regulatory
approval,
historically
plagued
by
inefficiencies
and
time
lags
due
limited
data
utilization,
now
faces
urgent
demands
for
accelerated
lead
identification.
Innovations
in
biological
computational
chemistry
have
spurred
shift
trial-and-error
methods
holistic
approaches
medicinal
chemistry.
Computational
techniques,
particularly
artificial
intelligence
(AI),
notably
machine
learning
(ML)
deep
(DL),
revolutionized
drug
development,
enhancing
analysis
predictive
modeling.
Natural
products
(NPs)
long
served
as
rich
sources
of
biologically
active
compounds,
with
many
successful
drugs
originating
them.
Advances
information
science
expanded
NP-related
databases,
enabling
deeper
exploration
AI.
Integrating
AI
into
NP
discovery
promises
discoveries,
leveraging
AI's
analytical
prowess,
including
generative
synthesis.
This
perspective
illuminates
current
landscape
addressing
strengths,
limitations,
future
trajectories
advance
this
vital
research
domain.
Current Research in Biotechnology,
Год журнала:
2020,
Номер
2, С. 88 - 102
Опубликована: Окт. 1, 2020
Since
the
early
research
efforts
focusing
on
bioactive
marine
substances
such
as
spongouridine,
from
sponge
Cryptotethya
crypta,
natural
products
(MNPs)
have
arisen
a
robust
and
sustainable
supplier
for
drug
leads.
Marine
present
definite,
unprecedented
structural
diversifications
varieties
of
interesting
biomedical
potentialities
with
novel
mechanisms
action.
Until
today,
eight
clinically
approved
products-based
drugs
by
two
worldwide
medical
organizations
(including
U.S.
FDA,
European
Medicines
Agency
(EMEA)),
been
developed
treatment
different
forms
carcinoma,
pain,
Alzheimer's
disease
other
current
challenges.
Recent
clinical
trial
analysis
disclosed
that
pipeline
contains
more
than
twenty
listed
candidates
in
trials
phase
III,
II,
or
I.
Herein,
we
recent
insights
centered
to
preclinically
investigated
compounds,
well
sampling
techniques,
extraction
&
identification
tools,
classification
MNPs,
some
reported
biological
activities,
challenges
faced
during
MNPs
development.
Biomedicine & Pharmacotherapy,
Год журнала:
2020,
Номер
134, С. 111091 - 111091
Опубликована: Дек. 16, 2020
The
marine
environment
is
an
enormous
source
of
marine-derived
natural
products
(MNPs),
and
future
investigation
into
anticancer
drug
discovery.
Current
progress
in
drugs
offers
a
rise
isolation
clinical
validation
numerous
innovative
developments
advances
therapy.
However,
only
limited
number
FDA-approved
are
available
due
to
several
challenges
limitations
highlighted
here.
use
chitosan
developing
promising
the
nanotech
sector
projected
for
prolific
delivery
system
(DDS).
cGAS-STING-mediated
immune
signaling
pathway
crucial,
which
has
not
been
significantly
investigated
therapy
needs
further
attention.
Additionally,
small
range
mediators
currently
involved
regulating
various
JAK/STAT
pathways,
such
as
immunity,
cell
death,
tumor
formation.
This
review
addressed
critical
features
associated
with
MNPs,
origin,
development
drugs.
Moreover,
recent
understanding
cancer
immunity
detailed
improved
human
health.
Food & Function,
Год журнала:
2020,
Номер
11(6), С. 5004 - 5016
Опубликована: Янв. 1, 2020
C.
elegans-based
activity
guided
and
size-based
isolation
of
antioxidant
peptide
fractions
from
a
sea
cucumber
protein
hydrolyzate
their
bioinformatic
characterization.
