Cardiorenal syndrome: clinical diagnosis, molecular mechanisms and therapeutic strategies

Acta Pharmacologica Sinica, Год журнала: 2025, Номер unknown

Опубликована: Фев. 5, 2025

Язык: Английский

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Pathogenesis of Sarcopenia in Chronic Kidney Disease—The Role of Inflammation, Metabolic Dysregulation, Gut Dysbiosis, and microRNA

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(15), С. 8474 - 8474

Опубликована: Авг. 3, 2024

Chronic kidney disease (CKD) is a progressive disorder associated with decline in function. Consequently, patients advanced stages of CKD require renal replacement therapies, such as dialysis and transplantation. Various conditions lead to the development CKD, including diabetes mellitus, hypertension, glomerulonephritis, among others. The metabolic hormonal dysregulation, uraemia hyperparathyroidism, well low-grade systemic inflammation. Altered homeostasis increases risk developing severe comorbidities, cardiovascular diseases or sarcopenia, which increase mortality. Sarcopenia defined muscle mass However, precise mechanisms that link sarcopenia are poorly understood. Knowledge about these linking might introduction treatment strategies could prevent wasting. This review discusses inflammatory mediators, gut microbiota dysbiosis, non-coding RNA alterations sarcopenia.

Язык: Английский

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Native potential probiotics and postbiotics improve the gut-kidney axis by the modulation of autophagy signaling pathway

Folia Microbiologica, Год журнала: 2025, Номер unknown

Опубликована: Март 12, 2025

Язык: Английский

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Gut microbiota regulates oxidative stress and inflammation: a double-edged sword in renal fibrosis

Cellular and Molecular Life Sciences, Год журнала: 2024, Номер 81(1)

Опубликована: Дек. 1, 2024

Gut microbiota is a complex and dynamic system that plays critical roles in human health various disease. Progressive chronic kidney disease (CKD) suggests patients irreversibly progress to end-stage need renal replacement treatments, including dialysis transplantation. Ample evidence indicates local oxidative stress inflammation play pivotal the pathogenesis progression of CKD dysbiosis gut microbiota. always accompanied by intestinal stress, which lead rapid systemic translocation bacterial-derived uraemic toxins, indoxyl sulphate, phenyl sulphate indole-3-acetic acid, consequent development aggravation fibrosis. Although have been extensively discussed, there paucity reports on effects fibrosis mediation inflammation. This review provides an overview fibrosis, briefly discusses regulation flora using microecological preparations natural products, such as resveratrol, curcumin emodin treatments for CKD, clear pathophysiological rationale design promising therapeutic strategies.

Язык: Английский

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Unveiling the causal effects of gut microbiome on trimethylamine N-oxide: evidence from Mendelian randomization

Frontiers in Microbiology, Год журнала: 2024, Номер 15

Опубликована: Окт. 25, 2024

The relationship between gut microbiome and trimethylamine oxide (TMAO) has not been fully elucidated. We aimed to assess the causal effects of different microbes on TMAO using Mendelian randomization (MR).

Язык: Английский

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