Epigenetic regulation of FOXP3 gene expression in relation to impaired function of regulatory T cells in systemic lupus erythematosus DOI Creative Commons
Parnian Fakour, Ata Shirizadeh,

Ahmad Tahamoli‐Roudsari

и другие.

Exploration of Immunology, Год журнала: 2024, Номер unknown, С. 640 - 657

Опубликована: Окт. 21, 2024

The impaired function of regulatory T (Treg) cells and the imbalance Treg/Th17 play a central role in developing autoimmune diseases such as systemic lupus erythematosus (SLE). Treg are crucial for maintaining immune homeostasis tolerance to self-antigens. One most important transcription factors that regulate differentiation is FOXP3 protein. Aberrant epigenetic modifications affecting gene expression consequently dysregulated have been implicated pathogenesis SLE. Therefore, understanding intricate interplay between pattern mechanisms (e.g., DNA methylation, histone non-coding RNAs microRNAs long RNAs) unravelling underlying Moreover, targeting these pathways may offer novel therapeutic strategies restoring balance ameliorating pathology. This review report aimed provide an update on controlling SLE disease.

Язык: Английский

Emerging Mechanisms and Biomarkers Associated with T-Cells and B-Cells in Autoimmune Disorders DOI
Azhagu Madhavan Sivalingam

Clinical Reviews in Allergy & Immunology, Год журнала: 2025, Номер 68(1)

Опубликована: Фев. 11, 2025

Язык: Английский

Процитировано

0
Epigenetic regulation of FOXP3 gene expression in relation to impaired function of regulatory T cells in systemic lupus erythematosus DOI Creative Commons
Parnian Fakour, Ata Shirizadeh,

Ahmad Tahamoli‐Roudsari

и другие.

Exploration of Immunology, Год журнала: 2024, Номер unknown, С. 640 - 657

Опубликована: Окт. 21, 2024

The impaired function of regulatory T (Treg) cells and the imbalance Treg/Th17 play a central role in developing autoimmune diseases such as systemic lupus erythematosus (SLE). Treg are crucial for maintaining immune homeostasis tolerance to self-antigens. One most important transcription factors that regulate differentiation is FOXP3 protein. Aberrant epigenetic modifications affecting gene expression consequently dysregulated have been implicated pathogenesis SLE. Therefore, understanding intricate interplay between pattern mechanisms (e.g., DNA methylation, histone non-coding RNAs microRNAs long RNAs) unravelling underlying Moreover, targeting these pathways may offer novel therapeutic strategies restoring balance ameliorating pathology. This review report aimed provide an update on controlling SLE disease.

Язык: Английский

Процитировано

1