Epigenetic regulation of FOXP3 gene expression in relation to impaired function of regulatory T cells in systemic lupus erythematosus DOI Creative Commons
Parnian Fakour, Ata Shirizadeh,

Ahmad Tahamoli‐Roudsari

et al.

Exploration of Immunology, Journal Year: 2024, Volume and Issue: unknown, P. 640 - 657

Published: Oct. 21, 2024

The impaired function of regulatory T (Treg) cells and the imbalance Treg/Th17 play a central role in developing autoimmune diseases such as systemic lupus erythematosus (SLE). Treg are crucial for maintaining immune homeostasis tolerance to self-antigens. One most important transcription factors that regulate differentiation is FOXP3 protein. Aberrant epigenetic modifications affecting gene expression consequently dysregulated have been implicated pathogenesis SLE. Therefore, understanding intricate interplay between pattern mechanisms (e.g., DNA methylation, histone non-coding RNAs microRNAs long RNAs) unravelling underlying Moreover, targeting these pathways may offer novel therapeutic strategies restoring balance ameliorating pathology. This review report aimed provide an update on controlling SLE disease.

Language: Английский

Emerging Mechanisms and Biomarkers Associated with T-Cells and B-Cells in Autoimmune Disorders DOI
Azhagu Madhavan Sivalingam

Clinical Reviews in Allergy & Immunology, Journal Year: 2025, Volume and Issue: 68(1)

Published: Feb. 11, 2025

Language: Английский

Citations

0
Epigenetic regulation of FOXP3 gene expression in relation to impaired function of regulatory T cells in systemic lupus erythematosus DOI Creative Commons
Parnian Fakour, Ata Shirizadeh,

Ahmad Tahamoli‐Roudsari

et al.

Exploration of Immunology, Journal Year: 2024, Volume and Issue: unknown, P. 640 - 657

Published: Oct. 21, 2024

The impaired function of regulatory T (Treg) cells and the imbalance Treg/Th17 play a central role in developing autoimmune diseases such as systemic lupus erythematosus (SLE). Treg are crucial for maintaining immune homeostasis tolerance to self-antigens. One most important transcription factors that regulate differentiation is FOXP3 protein. Aberrant epigenetic modifications affecting gene expression consequently dysregulated have been implicated pathogenesis SLE. Therefore, understanding intricate interplay between pattern mechanisms (e.g., DNA methylation, histone non-coding RNAs microRNAs long RNAs) unravelling underlying Moreover, targeting these pathways may offer novel therapeutic strategies restoring balance ameliorating pathology. This review report aimed provide an update on controlling SLE disease.

Language: Английский

Citations

1