Journal of Obstetrics and Gynaecology Research,
Год журнала:
2022,
Номер
49(3), С. 912 - 919
Опубликована: Дек. 29, 2022
To
investigate
the
association
of
systemic
immune-inflammation
index
(SII)
and
immune-response
(SIRI)
with
adverse
perinatal
outcomes
in
pregnant
women
coronavirus
disease
2019
(COVID-19).The
cases
were
divided
into
(1)
Mild-moderate
COVID-19
group
(n
=
2437)
(2)
Severe-critical
212).
Clinical
characteristics,
outcomes,
SII
(neutrophilXplatelet/lymphocyte),
SIRI
(neutrophilXmonocyte/lymphocyte)
compared
between
groups.
Afterward,
values
subgroups
based
on
pregnancy
complications,
neonatal
intensive
care
unit
(NICU)
admission,
maternal
mortality.
A
receiver
operator
characteristic
analysis
was
performed
for
determination
optimal
cutoff
prediction
severity,
NICU
mortality.Both
significantly
higher
complicated
(p
<
0.05).
Cutoff
severe-critical
1309.8
SII,
2.3
SIRI.
For
973.2
1.6.
1045.4
1.8
calculated
admission.
Finally,
cut-off
1224.2
2.4
found
mortality.SII
might
be
used
combination
other
clinical
findings
poor
outcomes.
Obstetrics and Gynecology,
Год журнала:
2022,
Номер
unknown
Опубликована: Окт. 27, 2022
To
investigate
perinatal
complications
associated
with
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
infection
during
pregnancy
in
the
four
major
waves
of
disease
2019
(COVID-19)
pandemic
Bronx,
New
York.This
retrospective
cohort
study
included
all
patients
who
delivered
at
a
single
academic
medical
center
between
March
1,
2020,
and
February
13,
2022.
SARS-CoV-2
positivity
was
defined
as
positive
test
result
pregnancy.
Primary
outcomes
were
preterm
birth,
low
birth
weight,
stillbirth,
cesarean
delivery,
preeclampsia
infection.
Secondary
analyses
examined
by
predominant
variant
time
Group
differences
categorical
variables
tested
using
χ
tests.Of
8,983
delivered,
638
(7.1%)
for
Age,
race,
ethnicity,
comorbidities
did
not
differ
significantly
SARS-CoV-2-positive
SARS-CoV-2-negative
cohorts
(
P
>.05).
There
marked
increase
results
individuals
gave
Omicron
wave
(140/449,
31.2%).
However,
among
infection,
rate
(9.9%)
lower
than
original
(20.3%)
Alpha
(18.4%)
<.05).
Vaccination
rates
before
rose
to
47.2%
hospitalized
Finally,
second-trimester
worse
compared
third-trimester
<.05).There
general
trend
toward
improvement
across
pregnant
The
more
infectious,
but
that
wave.
Transactions of the Royal Society of Tropical Medicine and Hygiene,
Год журнала:
2024,
Номер
118(7), С. 405 - 425
Опубликована: Янв. 31, 2024
Abstract
We
aimed
to
estimate
the
associations
between
coronavirus
disease
2019
(COVID-19)
vaccination
during
pregnancy
and
risks
of
adverse
perinatal
outcomes.
performed
a
literature
search
in
PubMed,
Web
Science
Embase
identify
eligible
studies
published
up
24
September
2023,
yielding
39
included
studies.
Pooled
relative
(RRs)
with
95%
confidence
intervals
(CIs)
were
calculated
random
effects
model.
The
pooled
results
showed
that
COVID-19
(any
type
or
dose
any
trimester)
was
not
associated
an
increased
risk
In
particular,
third
trimester
decreased
preterm
birth
(<37
weeks)
(RR
0.85
[95%
CI
0.74
0.98]),
5-min
Apgar
<7
0.87
0.78
0.97])
neonatal
intensive
care
unit
(NICU)
admission
0.90
0.86
0.95]).
inverse
also
found
analysis
one-dose
miscarriage
0.83
0.72
0.96])
0.80
1.00])
two-dose
NICU
0.76
0.96]).
does
increase
negative
outcomes
for
mother
baby.
Frontiers in Pediatrics,
Год журнала:
2022,
Номер
10
Опубликована: Апрель 29, 2022
In
the
late
2020s,
less
than
1
year
into
coronavirus
disease
2019
(COVID-19)
pandemic,
several
anti-severe
acute
respiratory
syndrome
2
(SARS-CoV-2)
vaccines
were
introduced
on
a
worldwide
scale,
with
significant
positive
impact
consequences
of
for
high-risk
population
groups.
case
most
bacterial
or
viral
infections,
pregnant
women
are
at
increased
risk
complications,
however,
neither
nor
breastfeeding
included
in
first
round
randomized
clinical
trials
evaluating
safety
and
effectiveness
COVID-19
vaccines,
because
ethical
concerns.
Nevertheless,
anti-SARS-CoV-2
have
not
been
expressly
contraindicated
during
pregnancy
breastfeeding,
observational
data
immune
response,
adverse
effects,
efficacy
progressively
gathered
2021.
The
vast
majority
these
is
reassuring
what
concerns
side
effects
infants
points
out
protecting
against
COVID-19-related
complications.
Despite
this,
hesitancy
being
vaccinated
still
real.
this
mini-review,
we
resume
available
women,
as
well
systemic
mucosal
women.
Moreover,
offer
an
updated
overview
European,
North
American,
Australasian
recommendations
concerning
vaccination
order
to
safely
ensure
highest
protection
their
infants.
Journal of Reproductive Healthcare and Medicine,
Год журнала:
2023,
Номер
4, С. 2 - 2
Опубликована: Янв. 23, 2023
More
than
533
million
Coronavirus
Disease
2019
(COVID-19)
cases
and
associated
6
fatalities
were
reported
globally
whereas
43
0.5
deaths
in
India
till
June
2022.
Maharashtra
state
alone
about
one-third
of
the
total
COVID-19
early
period
pandemic.
The
lack
epidemiological,
demographic,
impact
data
on
pregnant
women
newborns,
advocated
need
for
recording
documenting
population
specific
clinical
management
policy
decisions
India.
PregCovid
registry
was
launched
April
2020
by
Indian
Council
Medical
Research-National
Institute
Research
Reproductive
Child
Health,
Mumbai,
collaboration
with
Education
Drugs
Department,
Government
Maharashtra,
Topiwala
National
College
Bai
Yamunabai
Laxman
Nair
Charitable
Hospital
to
gain
insights
into
socio-epidemiological
characteristics
lab
confirmed
assess
its
maternal
neonatal
outcomes.
has
collected
8428
postpartum
from
19
participating
centers
across
a
near
real-time
manner.
first
that
delta
variant
(B.1.617.2)
dominant
second
wave
more
lethal
(case
fatality
rate
5.7%)
alpha
(0.7%)
There
also
higher
incidence
moderate
severe
cases,
intensive
care
admissions
complications
including
pre-eclampsia,
low
birth
weight
preterm
deliveries
during
wave.
omicron
third
pandemic
exhibited
transmission
compared
previous
two
waves,
causing
surge
but
minimally
impacting
adverse
further
analyzed
comorbidities,
coinfections,
twin
pregnancies,
outcomes,
while
providing
crucial
inputs
improve
newborn
health
model
can
be
replicated
at
tertiary
hospitals
understand
various
maternal-neonatal
evidence
generated
useful
improved
contributed
decision
vaccination
envisions
similar
regional,
national
international
registries
form
an
consortium
sharing
reporting
promote
global
level
interventions
advocates
sustainable
collective
response
coverage.
Influenza and Other Respiratory Viruses,
Год журнала:
2023,
Номер
17(9)
Опубликована: Сен. 1, 2023
We
examined
associations
between
mild
or
asymptomatic
prenatal
SARS-CoV-2
infection
and
preterm
live
birth
in
a
prospective
cohort
study.
During
August
2020-October
2021,
pregnant
persons
were
followed
with
systematic
surveillance
for
RT-PCR
serologically
confirmed
until
pregnancy
end.
The
association
was
assessed
using
Cox
proportional-hazards
regression.
Among
954
birth,
185
(19%)
had
123
(13%)
birth.
adjusted
hazard
ratio
the
1.28
(95%
confidence
interval
0.82-1.99,
Journal of Intensive Care Medicine,
Год журнала:
2024,
Номер
39(6), С. 577 - 594
Опубликована: Фев. 6, 2024
Background
Coronaviruses
have
been
the
cause
of
3
major
outbreaks
during
last
2
decades.
Information
on
coronavirus
diseases
in
pregnant
women
is
limited,
and
even
less
known
about
seriously
ill
women.
Data
are
also
lacking
regarding
real
burden
disease
2019
(COVID-19)
infection
from
low/middle-income
countries.
The
aim
this
study
was
to
determine
characteristics
clinical
course
COVID-19
pregnant/puerperal
admitted
ICUs
Turkey.
Methods
This
a
national,
multicenter,
retrospective
study.
population
comprised
all
SARS-CoV-2-infected
participating
between
1
March
2020
January
2022.
demographics,
comorbidities,
illness
severity,
therapies,
extrapulmonary
organ
injuries,
non-COVID-19
infections,
maternal
fetal/neonatal
outcomes
were
recorded.
LASSO
logistic
regression
multiple
analyses
used
identify
predictive
variables
terms
ICU
mortality.
Results
A
total
597
patients
(341
women,
255
puerperal
women)
59
44
hospitals
included
these
patients,
87.1%
unvaccinated.
primary
reason
for
admission
acute
hypoxemic
respiratory
failure
522
(87.4%),
plus
shock
14
(2.3%),
ischemic
cerebrovascular
accident
(CVA)
5
(0.8%),
preeclampsia/eclampsia/HELLP
syndrome
6
(1.0%),
post-caesarean
follow-up
36
(6.0%).
Nonsurvivors
sicker
than
survivors
upon
admission,
with
higher
APACHE
II
(
p
<
0.001)
SOFA
scores
0.001).
181
(30.3%)
died
280
(46.6%)
had
received
invasive
mechanical
ventilation
(IMV).
Myocardial
injury,
highest
score
stay,
LDH
levels
AST
average
daily
dose
corticosteroids,
IMV,
prophylactic
anticoagulation
(compared
therapeutic
anticoagulation),
PaO
/FiO
ratio
<100,
pulmonary
embolism,
identified
as
predictors
Rates
premature
birth
(46.4%),
cesarean
section
(53.7%),
fetal
distress
(15.3%),
stillbirth
(6.5%),
low
weight
(19.4%)
high.
neonatal
death
(8%)
(21%)
high
among
live-born
infants.
Conclusions
Severe/critical
pregnancy/puerperal
period
associated
mortality
complication
rates
International Journal of Environmental Research and Public Health,
Год журнала:
2022,
Номер
19(24), С. 16631 - 16631
Опубликована: Дек. 10, 2022
Severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV2)
infection
has
been
associated
with
greater
morbidity
and
increased
mortality
in
certain
populations,
such
as
those
chronic
medical
conditions,
the
elderly,
pregnant
women.
Our
goal
was
to
determine
if
COVID-19
during
pregnancy
risk
of
preeclampsia
a
population
women
factors
for
preeclampsia.
We
present
prospective
observational
matched
case–control
study
100
deliveries
confirmed
SARS-CoV2.
Specifically,
we
investigated
maternal
neonatal
outcomes
high-risk
Among
COVID-19,
severity
symptoms
incidence
preeclampsia,
but
not
pre-existing
diabetes
or
hypertension.
Women
more
severe
were
likely
delivery
pre-term
smaller
babies.
After
adjusting
diabetes,
hypertensive
had
an
aOR4.3
[1.5,12.4]
compared
non-hypertensive
COVID-19.
hypertension,
aOR3.9
[1.2,12.5].
This
relationship
seen
among
without
For
who
developing
only
they
also
diagnosed
suggesting
that
our
is
Placenta,
Год журнала:
2023,
Номер
141, С. 84 - 93
Опубликована: Авг. 11, 2023
Excess
inflammation
and
oxidative
stress
are
common
themes
in
many
pathologies
of
pregnancy
including
preeclampsia
more
recently
severe
COVID-19.
The
risk
increases
following
maternal
infection
with
COVID-19,
potentially
relating
to
significant
overlap
pathophysiology
endothelial,
vascular
immunological
dysfunction
both.
Identifying
a
therapy
which
addresses
these
injurious
processes
stabilises
the
endothelial
system
would
help
address
global
burden
neonatal
morbidity
mortality
they
cause.
Sulforaphane
is
naturally
occurring
phytonutrient
found
most
densely
within
cruciferous
vegetables.
It
has
anti-inflammatory,
antioxidant
immune
modulating
properties
via
upregulation
phase-II
detoxification
enzymes.
This
review
will
cover
pathways
shared
by
COVID-19
offer
potential
therapeutic
target
nuclear
factor
erythroid
2-related
form
sulforaphane.
